The profound impact of mitochondrion in cellular metabolism has been well documented. Since type 2 diabetes (T2D) is a metabolic disorder, mitochondrial dysfunction is intricately linked with the disease pathogenesis.
Sajoy Kanti Saha +7 more
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The discovery of genetic control of enzyme and virus synthesis: 1965 Nobel Prize Laureates André Lwoff, François Jacob, Jacques Monod [PDF]
The middle of the 20th century was marked by a number of significant events in molecular biology, among which the groundbreaking discovery of the double helix of DNA, which could self-replicate and thus perform the main life function; the isolation of ...
O. P. Matyshevska +2 more
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Marine algal toxins: Biochemistry, genetics, and molecular biology [PDF]
Toxic compounds are frequently, but not universally, associated with algal blooms. Several dinoflagellate and diatom species are capable of toxin synthesis. Some bacteria are also capable of synthesizing at least one family of “algal” toxins. Previous work on algal toxins can be broadly grouped in four categories: observations on the variability in ...
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Chemical biology utilizes chemical principles to modulate systems to either investigate the underlying biology or create new function. Over recent years, chemical biology has received particular attention of many scientists in the life sciences from ...
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Structural basis of ribosomal RNA transcription regulation
Ribosomal RNA (rRNA) expression is regulated at the initiation stage of RNA synthesis. Here, the authors report cryo-EM structures of E. coli RNA polymerase and rRNA promoter complex with DksA/ppGpp on the way to open complex formation, identifying key ...
Yeonoh Shin +5 more
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Over the recent years, biochemistry has become responsible for explaining living processes such that many scientists in the life sciences from agronomy to medicine are engaged in biochemical research.
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No evidence of citation bias as a determinant of STEM gender disparities in US biochemistry, genetics and molecular biology research [PDF]
The lack of females in many Science Technology, Engineering and Mathematics (STEM) subjects in the USA is an ongoing concern, with many initiatives attempting to redress this imbalance. Some life sciences are apparently areas of relatively good practice, with higher proportions of female researchers than most other STEM subjects.
Mike Thelwall, Tamara Nevill
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Structural basis for high-affinity actin binding revealed by a β-III-spectrin SCA5 missense mutation
The disease causing L253P mutation in the actin-binding domain (ABD) of β-III-spectrin drastically increases actin-binding affinity. Here, the authors present the cryo-EM structure of F-actin complexed with the ABD mutant and double electron–electron ...
Adam W. Avery +7 more
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Implementing the American Society for Biochemistry and molecular biology recommended curriculum in a biochemistry and molecular biology degree program in a genetics and biochemistry department: The Clemson University experience [PDF]
AbstractThis article describes the undergraduate biochemistry degree program at a medium‐sized, “state‐supported,” land‐grant university and how this degree program implements the curriculum recommended by the Educational and Professional Development Committee of the American Society for Biochemistry and Molecular Biology.The abbreviation used is ...
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Historical perspective and importance of microbiology in modern era
This paper introduces the historical view of microbiology and discuss the importance of microorganisms not only as causative agents of disease but also as important contributors to food production, antibiotic manufacture, vaccine development, and ...
Anjali Sethi , Molly Madan
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