Results 41 to 50 of about 143,906 (309)
Rare disorders have many faces: in silico characterization of rare disorder spectrum
Orphanet Journal of Rare Diseases, 2022 Background The diagnostic journey for many rare disease patients remains challenging despite use of latest genetic technological advancements. We hypothesize that some patients remain undiagnosed due to more complex diagnostic scenarios that are ...
Simona D. Frederiksen +5 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Schematic relationship between biochemistry, genetics and molecular biology
, 2011 The image's scheme show the connection between biochemistry, molecular biology and genetics, also explaining the relationships of functions, genes and proteinsComponente Curricular::Ensino Médio ...
Desconhecido
core +1 more source
PathogensGrapevine (Vitis vinifera L.) cultivation is an important agricultural sector worldwide. Its expansion into new areas, like Kazakhstan, brings significant phytosanitary risks.
Karlygash P. Aubakirova +5 more
doaj +1 more source
Dissection of the Interplay between Class I PI3Ks and Rac Signaling in Phagocytic Functions
The Scientific World Journal, 2010 Phagocytes, like neutrophils and macrophages, are specialized cells evolved to clear infectious pathogens. This function resides at the core of innate immunity and requires a series of concerted events that lead first to migration to the infected tissue ...
Carlotta Costa +2 more
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Nature Communications, 2020 Transcription-repair coupling factors (TRCFs) are large ATPases that mediate the preferential repair of the transcribed DNA strand. Here the authors reveal the cryo-EM structure of DNA-bound Mfd, the bacterial TRCF, and provide molecular insights into ...
Christiane Brugger +6 more
doaj +1 more source
Human 3'‐phosphoadenosine 5'‐phosphosulfate (PAPS) Synthase: Biochemistry, Molecular Biology and Genetic Deficiency [PDF]
IUBMB Life, 2003 Abstract3'‐phosphoadenosine 5'‐phosphosulfate (PAPS) synthase (PAPSS) catalyzes the biosynthesis of PAPS which serves as the universal sulfonate donor compound for all sulfotransferase reactions. PAPSS forms PAPS in two sequential steps. First inorganic sulfate combines with ATP to form adenosine 5'‐phosphosulfate (APS) and pyrophosphate catalyzed by ...
openaire +2 more sources
, 2019 Biochemistry, Genetics and Molecular Biology gender differences in publishing and citation impact for the USA 1996-2014/8 - publication statistics, graphs and regression ...
Mike Thelwall (452631)
core +1 more source