Results 101 to 110 of about 143,906 (309)

The structure of a tetrameric septin complex reveals a hydrophobic element essential for NC-interface integrity

Communications Biology
The septins of the yeast Saccharomyces cerevisiae assemble into hetero-octameric rods by alternating interactions between neighboring G-domains or N- and C-termini, respectively.
Benjamin Grupp, Lukas Denkhaus, Stefan Gerhardt, Matthis Vögele, Nils Johnsson, Thomas Gronemeyer   +5 more
doaj   +1 more source

The NuA4 acetyltransferase and histone H4 acetylation promote replication recovery after topoisomerase I-poisoning

Epigenetics & Chromatin, 2019
Background Histone acetylation plays an important role in DNA replication and repair because replicating chromatin is subject to dynamic changes in its structures. However, its precise mechanism remains elusive.
Chiaki Noguchi, Tanu Singh, Melissa A. Ziegler, Jasmine D. Peake, Lyne Khair, Ana Aza, Toru M. Nakamura, Eishi Noguchi   +7 more
doaj   +1 more source

Proteomics: more than just biochemistry [PDF]

, 2005
Growth of the so-called 'omics' technologies may appear to be simply a case of giving new, trendy names to boring, old-fashioned technology. After all, who would dispute that genomics is just genetics and molecular biology, glycomics is the study of ...
Greenwell, P., Rughooputh, S.
core  

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Engineered NLS-chimera downregulates expression of aggregation-prone endogenous FUS

Nature Communications
Importin β-superfamily nuclear import receptors (NIRs) mitigate mislocalization and aggregation of RNA-binding proteins (RBPs), like FUS and TDP-43, which are implicated in neurodegenerative diseases.
Miyuki Hayashi, Amandeep Girdhar, Ying-Hui Ko, Kevin M. Kim, Jacquelyn A. DePierro, Joseph R. Buchler, Nikhita Arunprakash, Aditya Bajaj, Gino Cingolani, Lin Guo   +9 more
doaj   +1 more source

Representing and analysing molecular and cellular function in the computer

, 2000
Determining the biological function of a myriad of genes, and understanding how they interact to yield a living cell, is the major challenge of the post genome-sequencing era.
Naim, A., Helden, J., Van, Wernisch, L, Eldridge, M, Wodak, S. J., Gilbert, D, Mancuso, R, Helden, JV, Wodak, SJ, Helden, J.,, Wernisch, Lorenz, Naim, A, Wernisch, L., Eldridge, Matthew, van Helden, Jacques, Mancuso, R., Wodak, Shoshana, Eldridge, M., Mancuso, Renato, Gilbert, D.   +19 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Bibliometric analysis of beneficial cannabis research: Performance analysis and science mapping from 2012 to 2022 and focus on Morocco

Toxicology Reports
Beneficial cannabis use has sparked growing interest among researchers, leading to an increase in empirical studies exploring its phytochemistry and applications. However, understanding the overall research orientation remains limited. This study aims to
Fatima-Zahrae Laaboudi, Mohamed Rejdali, Amin Salhi, Abedellah Elyoussfi, Abdelmonaem Talhaoui, Hassan Amhamdi, M’hamed Ahari   +6 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source