Results 81 to 90 of about 143,906 (309)

Introductory Biology

, 2020
7.016 Introductory Biology provides an introduction to fundamental principles of biochemistry, molecular biology and genetics for understanding the functions of living systems.
Sinha, Diviya, Imperiali, Barbara, Amon, Angelika   +2 more
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

In vivo structure profiling reveals human cytosolic and mitochondrial tRNA structurome and interactome in response to stress

Nature Communications
Transfer RNA (tRNA) is the most abundant cellular RNA family in terms of copy numbers. It not only folds into defined structures but also has complex cellular interaction networks involving aminoacyl-tRNA synthetases, translation factors, and ribosomes ...
Noah Peña, Yichen Hou, Christopher P. Watkins, Sihao Huang, Wen Zhang, Christopher D. Katanski, Tao Pan   +6 more
doaj   +1 more source

Structure and catalytic regulation of Plasmodium falciparum IMP specific nucleotidase

Nature Communications, 2020
Plasmodium falciparum IMP-specific 5′-nucleotidase 1 (PfISN1) is of interest as a potential malaria drug target. Here, the authors report that IMP is a substrate, and ATP an allosteric activator, of PfISN1 and present PfISN1 crystal structures in the ...
Loïc Carrique, Lionel Ballut, Arpit Shukla, Neelakshi Varma, Resmi Ravi, Sébastien Violot, Bharath Srinivasan, Umesh Tippagondanahalli Ganeshappa, Sonia Kulkarni, Hemalatha Balaram, Nushin Aghajari   +10 more
doaj   +1 more source

Integrated cell biology/biochemistry/molecular genetics laboratories: the cytoplasmic genome projects

Journal of Industrial Microbiology and Biotechnology, 2000
This paper describes an integrated laboratory project for intermediate to advanced undergraduate students. The project spans an entire academic quarter (10 weeks) and involves a series of operations that give students experience with fundamental techniques in cell biology, molecular biology, biochemistry, genomics, and bioinformatics.
openaire   +2 more sources

A Critical Review of Animal Models Used in Acute Myeloid Leukemia Pathophysiology [PDF]

, 2019
Acute myeloid leukemia (AML) is one of the most frequent, complex, and heterogeneous hematological malignancies. AML prognosis largely depends on acquired cytogenetic, epigenetic, and molecular abnormalities.
Hiba El Hajj, Nadine Darwiche, Hleihel, Rita S., Maguy Hamieh, El-Hajj, Hiba Ahmad, Marwan El Sabban, Bazarbachi, Ali Abdul Hamid, El-Sabban, Marwan E., Rita Hleihel, Hamieh, Maguy, Jishi, Batoul, Ali Bazarbachi, Hala Skayneh, Batoul Jishi, Skayneh, Hala, Darwiche, Nadine D.   +15 more
core   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Positive association between ATP2B1 rs17249754 and essential hypertension: a case-control study in Burkina Faso, West Africa

BMC Cardiovascular Disorders, 2019
Background Genetic and environment play a significant role in the etiology of essential hypertension (EH). Recently STK39 rs3754777, ATP2B1 rs2681472 and rs17249754 have been associated with BP variation and hypertension.
Herman Karim Sombié, Jonas Koudougou Kologo, Daméhan Tchelougou, Serge Yannick Ouédraogo, Abdoul Karim Ouattara, Tegwindé Rebecca Compaoré, Bolni Marius Nagalo, Abel Pegdwendé Sorgho, Issoufou Nagabila, Serge Théophile Soubeïga, Florencia Wendkuuni Djigma, Albert Théophane Yonli, Patrice Zabsonré, Hassanata Millogo, Jacques Simporé   +14 more
doaj   +1 more source