Results 101 to 110 of about 576,788 (310)

Mitochondrial translation is the primary determinant of secondary mitochondrial complex I deficiencies

iScience
Summary: Individual complexes of the mitochondrial oxidative phosphorylation system (OXPHOS) are not linked solely by their function; they also share dependencies at the maintenance/assembly level, where one complex depends on the presence of a different
Kristýna Čunátová, Marek Vrbacký, Guillermo Puertas-Frias, Lukáš Alán, Marie Vanišová, María José Saucedo-Rodríguez, Josef Houštěk, Erika Fernández-Vizarra, Jiří Neužil, Alena Pecinová, Petr Pecina, Tomáš Mráček   +11 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Homocysteine: Biochemistry, Molecular Biology and Role in Disease. [PDF]

Biomolecules, 2021
Hermann A, Sitdikova G.
europepmc   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Histone methyltransferase SET-18/SMYD2-mediated activation of NADase TIR-1d/SARM1 increases mtROS to promote aging

iScience
Summary: Histone lysine methylation regulates the expressions of mitochondrial function-related genes, which presents a “nucleus-to-mitochondria” signal communication, playing a key role in aging control. However, the underlying mechanisms remain elusive
Dongxue Xue, Xin Su, Aaron Pambu Lelo, Yongjun Zhang, Xueqing Ba, Cheng-gang Zou, Aohe Ma, Yao Liu, Xiaoxue Li   +8 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

PD-1 deficiency protects experimental colitis via alteration of gut microbiota (vol 50, pg 578, 2017) [PDF]

, 2018
The BMB Reports would like to correct in the ACKNOWLEDGEMENTS of BMB Rep. 50(11): 578-583 titled PD-1 deficiency protects experimental colitis via alteration of gut microbiota.
Kim, Ji-Hae, Sung, Young Chul, Lee, Seung-Woo, Song, Mi-Young, Park, Seong Jeong, Park, Yunji   +5 more
core   +1 more source

Exploring multiorgan mitochondrial dysfunction in the switch toward progressive MASLD in AMLN mice

iScience
Summary: Hepatic mitochondrial maladaptation features the transition from metabolic dysfunction-associated steatotic liver disease (MASLD) to Steatohepatitis (MASH) up to fibrosis/cirrhosis.
Marica Meroni, Erika Paolini, Miriam Longo, Michele Battistin, Daniele Dondossola, Michela Ripolone, Laura Napoli, Ettore Mosca, Stefania Corti, Paola Dongiovanni   +9 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Identification of the client-binding site on the Golgi membrane protein adaptor Vps74/yGOLPH3

iScience
Summary: Vps74 and its mammalian counterpart GOLPH3 are COPI associated protein sorting adaptors that function to maintain the cisternal distributions of a diversity of Golgi integral membrane protein clients by binding to their short cytoplasmically ...
Agnieszka M. Lesniak, Ziyun Ye, David K. Banfield   +2 more
doaj   +1 more source