Results 121 to 130 of about 576,788 (310)
iScienceSummary: The Ets transcription factors induce the expression of Tie2 and VE-cadherin. However, the regulation of these factors remains unknown. Here, we found that the gene encoding the Ets factor Elf2 was hypermethylated in Camkkβ-deficient (Camkkβ ...
Dong-Mei Wang +7 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
iScienceSummary: Fibroblasts can be transformed into myofibroblasts under pro-fibrotic conditions, which are characterized by increased contractility and reduced matrix degradation.
Ching-Lung Wu +8 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
The UFSP2-C1orf27 complex positions nascent GPCRs to the ufmylation system for ER export control
iScienceSummary: The ufmylation system is implicated in multiple cellular processes and human diseases; our recent study has identified its function in protein trafficking, but detailed mechanisms remain elusive. Here, we reveal cooperative actions of ufmylation
Xin Xu +5 more
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Müller, M./editor. Biochemistry and molecular biology of parasites [PDF]
, 1995 J. Joseph Marr, Miklós Müller/editors. Biochemistry and molecular biology of parasites The study of parasitic organisms at the molecular level has yielded fascinating new insights of great medical, social, and economical importance, and has pointed the
The Rockefeller University
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Spanish Society of Biochemistry and Molecular Biology: celebrating 50 years [PDF]
, 2015 Ciencia para todos: Programa de Divulgación de la SEBBM.-- et al.Since its foundation in 1963, the objectives of the Spanish Society of Biochemistry and Molecular Biology (SEBBM) have been to foster research, encourage the transfer of knowledge ...
Pajares, María Ángeles +3 more
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