Results 71 to 80 of about 576,788 (310)

Regulation of Xvelo assembly by centrosomal proteins

iScience
Summary: The oocyte Balbiani body (Bb) is a conserved membraneless organelle required for germline specification in many species. Here we report that when overexpressed in mammalian somatic cells, Xenopus Velo (Xvelo), the Bb matrix protein could ...
Divyanshi, Meining Li, Elvan Böke, Jing Yang   +3 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

k-Hefutoxin1, a novel toxin from the scorpion Heterometrus fulvipes with unique structure and function - Importance of the functional diad in potassium channel selectivity [PDF]

, 2002
Copyright © 2002 by The American Society for Biochemistry and Molecular Biology, Inc.Kellathur N. Srinivasana, Vaithiyalingam Sivaraja, Isabelle Huys, Toru Sasaki, Betty Cheng, Thallampuranam Krishnaswamy S.
Sato, K., Gopalakrishnakone, P., Bowie, J., Ranganathan, S., Kini, R.M., Bowie, H.J., San, B.C., Sivaraja, V., Kumar, T.K., Huys, I., San, C., Srinivasan, K., Cheng, B., Kini, M., Tytgat, J., Sasaki, T., Kumar, T., Yu, C., Srinivasan, K.N.   +18 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Biochemistry and molecular biology of anammox bacteria

Critical Reviews in Biochemistry and Molecular Biology, 2009
Anaerobic ammonium-oxidizing (anammox) bacteria are one of the latest additions to the biogeochemical nitrogen cycle. These bacteria derive their energy for growth from the conversion of ammonium and nitrite into dinitrogen gas in the complete absence of oxygen.
Jetten, M.S.M., Niftrik, L. van, Strous, M., Kartal, B., Keltjens, J.T., Camp, H.J. Op den   +5 more
openaire   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Digital portfolios for enhanced online learning in first-year Biochemistry [PDF]

, 2020
Student success and retention is of the utmost importance in higher education, particularly for large first year courses in STEM disciplines which involve understanding complex concepts and navigating a high level of content.
Love, Christopher
core  

Molecular basis for SMC rod formation and its dissolution upon DNA binding. [PDF]

, 2015
SMC condensin complexes are central modulators of chromosome superstructure in all branches of life. Their SMC subunits form a long intramolecular coiled coil, which connects a constitutive "hinge" dimerization domain with an ATP-regulated "head ...
Soh, Young-Min, Stephan Gruber, Kim, Cheolhee, Kim, Y.-G., Kim, YG, Oh, B., Bürmann, F., Soh, Y., Shin, H.-C., Oh, Byung-Ha, Shin, HC, Lee, H., Durand-Diebold, M., Jin, KS, S. Gruber, Lee, Hansol, Kim, Ho Min, Shin, Ho-Chul, Kim, HM, Buermann, Frank, Toseland, C., Kim, H.M., Oda, T, Soh, YM, Durand-Diebold, Marie-Laure, -Diebold, ML, Kim, Y., Gruber, S., Jin, Kyeong Sik, Bürmann, Frank, Oh, BH, Durand-Diebold, M.-L., Kim, Yeon-Gil, Kong, Min-Seok, Kim, C, Oda, Takashi, C. Kim, Lee, Nam Ki, M-L Durand-Diebold, Lee, N.K., Kim, H., Kim, Soo Jin, Sato, M., Gruber, S, Toseland, Christopher P., Oda, T., Lee, NK, M-S Kong, Diebold-Durand, Marie-Laure, Lee, N., Y.-G. Kim, Kim, C., Toseland, C.P., Soh, Young Min, Kim, Ho-Min, Gruber, Stephan, Soh, Y.-M., Oh, B.-H., Sato, Mamoru, Buermann, F., Kim, S., Jin, K.S., Shin, H., Kim, S.J., Kong, M.-S., Kong, M., S. J. Kim, Burmann, F, Jin, K., C. P. Toseland   +69 more
core   +1 more source

Sequential and synchronized hypertonicity-induced activation of Rel-family transcription factors is required for osmoprotection in renal cells

Heliyon, 2018
NF-κB and TonEBP belong to the Rel-superfamily of transcription factors. Several specific stimuli, including hypertonicity which is a key factor for renal physiology, are able to activate them. It has been reported that, after hypertonic challenge, NF-κB
Cecilia I. Casali, Luciana C. Erjavec, María del Carmen Fernández-Tome   +2 more
doaj   +1 more source