Results 61 to 70 of about 576,788 (310)

DHHC2 regulates fear memory formation, LTP, and AKAP150 signaling in the hippocampus

iScience, 2023
Summary: Palmitoyl acyltransferases (PATs) have been suggested to be involved in learning and memory. However, the underlying mechanisms have not yet been fully elucidated.
Meng-Die Li, Lu Wang, Yu-Qi Zheng, Dan-Hong Huang, Zhi-Xuan Xia, Jian-Min Liu, Dan Tian, Hui OuYang, Zi-Hao Wang, Zhen Huang, Xiao-Shan Lin, Xiao-Qian Zhu, Si-Ying Wang, Wei-Kai Chen, Shao-Wei Yang, Yue-Ling Zhao, Jia-An Liu, Zu-Cheng Shen   +17 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Towards molecular systems biology of gene transcription and regulation [PDF]

, 2010
Ten years after the determination of the RNA polymerase 11 structure, the basic mechanism of mRNA synthesis during gene transcription is known. In the future, the initiation and regulation of transcription must be studied with a combination of structural
Cramer, P., Cramer, Patrick
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

SR proteins regulate V₆exon splicing of CD44 pre-mRNA [PDF]

, 2016
CD44 pre-mRNA includes 20 exons, of which exons 1-5 (C1-C5) and exons 16-20 (C6-C10) are constant exons, whereas exons 6-15 (V1-V10) are variant exons. V6-exon-containing isoforms have been known to be implicated in tumor cell invasion and metastasis. In
Darren Reece Williams, Choi, Namjeong, Haihong Shen, Shen, Haihong, Yongchao Liu, Tiing Jen Loh, Heegyum Moon, Shengfu Shen, Da-Woon Jung, Liu, Yongchao, Williams, Darren Reece, Zheng, Xuexiu, Xuexiu Zheng, Jung, Da-Woon, Namjeong Choi, Jang, Ha Na, Moon, Heegyum, Loh, Tiing Jen, Ha Na Jang, Shen, Shengfu   +19 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

KIF3A tail domain phosphorylation is not required for ciliogenesis in mouse embryonic fibroblasts

iScience
Summary: Primary cilia are essential signaling organelles that protrude from most cells in the body. Heterodimeric kinesin-2 (KIF3A/KIF3B/KAP3) powers several intracellular transport processes, including intraflagellar transport (IFT), essential for ...
Ayoola S. Fasawe, Jessica M. Adams, Martin F. Engelke   +2 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Integrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug [PDF]

Our understanding of cellular events is hampered by the gap between the resolution at which we can observe events inside cells and our ability to replicate physiological conditions in test tubes.
Lee, Carolyn L, Wang, Hanyu, Cheng, Wenjing, Zhu, Xiyan, Anton, Leonie, Han, Leyan, Ho, Chi-Min, Cheng, W, Ho, CM, Li, E, Li, Emerson, Wang, H, Doud, Emma H., Ke, H, Zhu, X, Lee, CL, Ke, Hangjun, Cobb, DW, Han, L, Cowman, Alan F., Anton, L, Cowman, AF, Haile, MT, Haile, Meseret T., Dziekan, Jerzy M., Zhang, Guoan, Doud, EH, Zhang, G, Dziekan, JM, Cobb, David W., Nair, Anjali, Nair, A   +31 more
core   +2 more sources

Phospholipase D1 regulates cell migration in a lipase activity-independent manner [PDF]

, 2006
Cell migration, a complex biological process, requires dynamic cytoskeletal remodeling. Phospholipase D (PLD) generates phosphatidic acid, a lipid second messenger. Although PLD activity has been proposed to play a role in cytoskeletal rearrangement, the
Kim, JH, Pann-Ghill Suh, Kim, HW, Hyeona Jeon, Ryu, SH, Jung Hwan Kim, Suh, Pann-Ghill, Suh, PG, Sung Ho Ryu, Jeon, H, Hyun-wook Kim   +10 more
core   +1 more source