Results 91 to 100 of about 1,957,522 (351)
Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases
FEBS Letters, EarlyView.The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher +6 more
wiley +1 more source
iScience, 2021 Summary: Ubiquitination is a major post-translational modification of ribosomal proteins. The role of ubiquitination in the regulation of ribosome functions is still being elucidated.
Yuka Takehara +8 more
doaj
Solving the Tyranny of Pipetting [PDF]
arXiv, 2018 Stephen Quake is the Lee Otterson Professor of Bioengineering and Applied Physics at Stanford University. Here he reviews the early history of microfluidics and discusses more recent developments, with a focus on applications in biology and biochemistry.
arxiv
FEBS Letters, EarlyView.We present the first solution structure of the Ca2+‐depleted LETM1 F‐EF‐hand through a D676A/N678A Ca2+ binding‐deficient mutant, revealing a closed hydrophobic cleft caused by a unique F1‐helix pivot. The apo LETM1 F‐EF‐hand exhibits regiospecific hot and cold unfolding, sensitivity to physiological pH changes and potential for promiscuous heterotypic
Qi‐Tong Lin +2 more
wiley +1 more source
BioScript: programming safe chemistry on laboratories-on-a-chip [PDF]
, 2018 This paper introduces BioScript, a domain-specific language (DSL) for programmable biochemistry which executes on emerging microfluidic platforms. The goal of this research is to provide a simple, intuitive, and type-safe DSL that is accessible to life ...
Brisk, Philip +4 more
core
Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones
FEBS Letters, EarlyView.Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
wiley +1 more source
FEBS Letters, EarlyView.LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra +7 more
wiley +1 more source
arXiv, 2010 This is my attempt to answer Schr\"odinger's question: "What is Life?". In living cell the local combination of atoms is reproduced with incredible accuracy. In the case of protein biosynthesis the notion of the physical aspect of the process can be qualitatively enriched by taking into account the symmetry of conformational oscillations.
arxiv
FEBS Letters, EarlyView.This study explores the distinct molecular mechanisms underlying Lynch syndrome‐associated and sporadic colorectal cancer (CRC). By highlighting the therapeutic potential of targeting the PI3K‐Akt pathway in Lynch syndrome‐associated CRC and the Wnt pathway in sporadic CRC, the findings open avenues for personalised treatment strategies, aiming to ...
May J. Krause +2 more
wiley +1 more source
Nearsightedness of Electronic Matter and the Size of Viruses [PDF]
arXiv, 2010 I conjecture that the nearsightedness of component electronic matter largely determines the size of a virus. These two length scales, one from physics and one from biochemistry, are in fact the same dimension which connects our quantum and everyday worlds.
arxiv