Results 121 to 130 of about 1,493,364 (293)
Metabolic Features of Saliva Before and After Breast Cancer Surgery
MetabolitesBackground: Changes in salivary metabolites in patients after surgery can provide important information for fundamental research. Objectives: To analyze changes in the salivary metabolic profile before and after breast tumor surgery.
Denis V. Solomatin +2 more
doaj +1 more source
Organic residues - a resource for arable soils [PDF]
, 2005 An increased recirculation of urban organic residues to arable soils has several environmental benefits, but there is a need for reliable test systems to ensure that soil quality is maintained.
Odlare, Monica
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
The short-lived MATα2 transcriptional regulator is ubiquitinated in vivo [PDF]
, 1991 The substrates of ubiquitin-dependent proteolytic pathways include both damaged or otherwise abnormal proteins and undamaged proteins that are naturally short-lived. Few specific examples of the latter class have been identified, however.
Chau, Vincent +3 more
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LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Practical Methods of Biochemistry [PDF]
American Journal of Clinical Pathology, 1948 openaire +2 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Introducing various formative assessment methods in Biochemistry of Phase I MBBS Curriculum
National Journal of Physiology, Pharmacy and PharmacologyBackground: Assessment in competency-based medical education (CBME) focuses on improving learning as an ongoing and longitudinal assessment so that facilitators can identify the needs of the learner, plan remedial measures, and provide learning ...
Ranjita Santra +4 more
doaj +1 more source
Use of a distant reporter group as evidence for a conformational change in a sensory receptor [PDF]
, 1977 A highly sensitive method for demonstrating ligand-induced conformational changes in protein molecules in solution is described. The method utilizes an environmentally sensitive reporter group that is known to be distant from the active site.
Hartig, P. R. +2 more
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Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source