Results 41 to 50 of about 1,493,364 (293)

The Mechanism of Tubulin Assembly into Microtubules: Insights from Structural Studies

iScience, 2020
Summary: Microtubules are cytoskeletal components involved in pivotal eukaryotic functions such as cell division, ciliogenesis, and intracellular trafficking.
Marcel Knossow, Valérie Campanacci, Liza Ammar Khodja, Benoît Gigant   +3 more
doaj   +1 more source

GwAAP: A genome-wide amino acid coding-decoding quantitative proteomics system

iScience, 2022
Summary: Mass spectrometry-based proteomic technology has greatly improved and has been widely applied in various biological science fields. However, proteome-wide accurate quantification of proteins in signaling pathways remains challenging.
Li Cheng, Xuetong Yue, Zhaoyu Qin, Xiaogang Sun, Fuchu He, Junbiao Dai, Chen Ding   +6 more
doaj   +1 more source

A well-separated pairs decomposition algorithm for k-d trees implemented on multi-core architectures [PDF]

, 2014
Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.Variations of k-d ...
Akl S G, Bentley J L, Blelloch G E, Callahan P B, Cormen T, Har-Peled S, Hoecker A, Ivan D Reid, Knuth D E, McCool M, Moore A, Moore A W, Omohundro S M, Peter R Hobson, Raul H C Lopes, Samet H, Vaidya P M   +16 more
core   +1 more source

Tracking fructose 1,6-bisphosphate dynamics in liver cancer cells using a fluorescent biosensor

iScience
Summary: HYlight is a genetically encoded fluorescent biosensor that ratiometrically monitors fructose 1,6-bisphosphate (FBP), a key glycolytic metabolite.
Israel Pérez-Chávez, John N. Koberstein, Julia Malo Pueyo, Eduardo H. Gilglioni, Didier Vertommen, Nicolas Baeyens, Daria Ezeriņa, Esteban N. Gurzov, Joris Messens   +8 more
doaj   +1 more source

Escherichia coli NusG Links the Lead Ribosome with the Transcription Elongation Complex

iScience, 2020
Summary: It has been known for more than 50 years that transcription and translation are physically coupled in bacteria, but whether or not this coupling may be mediated by the two-domain protein N-utilization substance (Nus) G in Escherichia coli is ...
Robert S. Washburn, Philipp K. Zuber, Ming Sun, Yaser Hashem, Bingxin Shen, Wen Li, Sho Harvey, Francisco J. Acosta Reyes, Max E. Gottesman, Stefan H. Knauer, Joachim Frank   +10 more
doaj   +1 more source

Photoswitchable single-stranded DNA-peptide coacervate formation as a dynamic system for reaction control

iScience, 2021
Summary: In cells, segregation allows for diverse biochemical reactions to take place simultaneously. Such intricate regulation of cellular processes is achieved through the dynamic formation and disassembly of membraneless organelles via liquid-liquid ...
Wen Ann Wee, Hiroshi Sugiyama, Soyoung Park   +2 more
doaj   +1 more source

Conformational Transitions Accompanying Oligomerization of Yeast Alcohol Oxidase, a Peroxisomal Flavoenzyme [PDF]

, 1999
Alcohol oxidase (AO) is a homo-octameric flavoenzyme which catalyzes methanol oxidation in methylotrophic yeasts. AO protein is synthesized in the cytosol and subsequently sorted to peroxisomes where the active enzyme is formed.
Boteva, R, Filippi, B, van der Klei, IJ, Veenhuis, M, Visser, AJWG, Visser, Antonie J.W.G., Vriend, G   +6 more
core   +3 more sources

Sequential trypsin and ProAlanase digestions unearth immunological protein biomarkers shrouded by skeletal collagen

iScience
Summary: This study investigates the efficacy of proteomic analysis of human remains to identify active infections in the past through the detection of pathogens and the host response to infection.
Shevan Wilkin, Liam T. Lanigan, Nuria Montes, Mukul Sharma, Charlotte Avanzi, Donikë Sejdiu, Kerttu Majander, Saskia Pfrengle, Yun Chiang, Laura Kunz, Antje Dittmann, Frank Rühli, Pushpendra Singh, Maria Fontanals Coll, Matthew J. Collins, Alberto J. Taurozzi, Verena J. Schuenemann   +16 more
doaj   +1 more source

Application of FTIR Spectroscopy for Quantitative Analysis of Blood Serum: A Preliminary Study

Diagnostics, 2021
The aim of this study was to analyze the possibility of simultaneous determination of the concentration of components from the characteristics of FTIR spectra using the example of a model blood serum.
Lyudmila V. Bel’skaya, Elena A. Sarf, Denis V. Solomatin   +2 more
doaj   +1 more source

Predictive Collective Variable Discovery with Deep Bayesian Models

, 2019
Extending spatio-temporal scale limitations of models for complex atomistic systems considered in biochemistry and materials science necessitates the development of enhanced sampling methods.
Koutsourelakis, Phaedon-Stelios, Schöberl, Markus, Zabaras, Nicholas   +2 more
core   +1 more source