Results 11 to 20 of about 85,620 (210)

Comparison of Two Strategies of Analysis of Urinary Protein Composition for the Diagnosis and Follow-Up of Renal Diseases. [PDF]

Electrophoresis
ABSTRACT Proteinuria analysis is necessary to detect the early stages of kidney disease before the estimated glomerular filtration rate deteriorates and to monitor the progression of treated kidney disease. Electrophoresis is often the first orientation test, although this test is time‐consuming and its interpretation may be subjective.
Guyon J, Malaubier J, Pham HV, Arab LR, Pieroni L, Curutchet-Burtin ML, Segues R, Caspar-Bauguil S, Bérard AM.   +8 more
europepmc   +2 more sources

Six Years of Genetic Diagnosis of Severe Early-Onset Obesity in a French Cohort. [PDF]

Obes Sci Pract
ABSTRACT Objective Obesity is a multifactorial disease with a strong genetic component. It is imperative to enhance the identification of genetic variations in their early and severe manifestations in order to facilitate the development of personalized therapeutic strategies, informed clinical care, and the facilitation of genetic counseling.
Rama M, Blond E, Janin A, Di-Filippo M, Cuerq C, Marmontel O, Rollat-Farnier PA, Dieterlen E, Segrestin B, Nicolino M, Disse E, Perge K, Collin-Chavagnac D.   +12 more
europepmc   +2 more sources

Novel Dominant Splicing Variant in MPZ Associated With Unusual Charcot-Marie-Tooth Disease. [PDF]

J Peripher Nerv Syst
ABSTRACT Background and Aims Variants in the myelin protein zero coding MPZ gene are responsible for a broad spectrum of peripheral demyelinating and axonal neuropathies, including different types of Charcot–Marie–Tooth diseases, challenging for genotype–phenotype correlation.
Maino A, Hazane-Puch F, Petiot P, Roux-Buisson N, Rendu J, Fauré J, Hardy G.   +6 more
europepmc   +2 more sources

Liposome-Based Potential Vaccines Platforms that Are Noncytotoxic. [PDF]

ChemistryOpen
Engineered neoglycolipids were formulated with palmitic acid and 1‐palmitoyl‐2‐oleoyl‐sn‐glycero‐3‐phosphocholine into stable, noncytotoxic liposomes using a freeze–thaw/extrusion method. This proof‐of‐concept study demonstrates a modular liposomal vaccine platform, offering a safe and tunable carrier for antigen delivery, with potential applications ...
Mebarek S, Jacob K, Pierro CI, Romanini D, Fiore M.   +4 more
europepmc   +2 more sources

New developments in the synthesis of emicoron [PDF]

, 2018
This paper reports on the modification of two synthetic steps in the usual protocol used for obtaining EMICORON. EMICORON is a benzo[ghi]perylen-diimide, which was synthesized for the first time in our laboratory in 2012, and has shown to have in vivo ...
Bianco, Armandodoriano, Ciccola, Alessandro, Franceschin, Marco, Frezza, Claudio, Pitorri, Massimo, Serafini, Ilaria   +5 more
core   +1 more source

Les biomarqueurs en écotoxicologie : définition, intérêt, limite, usage [PDF]

Sciences, Eaux & Territoires, 2010
Les biomarqueurs sont des outils mis en oeuvre pour établir un diagnostic de risque environnemental. Leurs usages et leur intérêt, notamment dans la détermination du risque de pollution, sont devenus incontournables surtout depuis que la directive cadre ...
J. GARRIC, S. MORIN, F. VINCENT-HUBERT
doaj   +4 more sources

Lactoferrin efficiently counteracts the inflammation-induced changes of the iron homeostasis system in macrophages [PDF]

, 2017
Human lactoferrin (hLf), an 80-kDa multifunctional iron-binding cationic glycoprotein, is constitutively secreted by exocrine glands and by neutrophils during inflammation. hLf is recognized as a key element in the host immune defense system.
Aisen, Andrews, Baker, Barber, Cairo, Corna, Cutone, De Domenico, Donovan, Frazer, Frioni, Ganz, Ganz, Genin, Legrand, Mackenzie, Mazumder, Miller, Musci, Paesano, Paesano, Paesano, Paesano, Park, Puddu, Puddu, Recalcati, Ross, Scorneaux, Theil, Valenti, Ward   +31 more
core   +2 more sources

Draft Genome Sequence of an International Clonal Lineage 1 Acinetobacter baumannii Strain from Argentina [PDF]

, 2014
In the last few years Acinetobacter baumannii has emerged worldwide as an important nosocomial pathogen in medical institutions. Here, we present the draft genome sequence of the international clonal lineage 1 (ICL1) A.
Centron, Daniela, Déraspe, Maxime, Ramirez, Maria Soledad, Roy, Paul H., Traglia, German Matias, Vilacoba, Elisabet   +5 more
core   +1 more source

Active-Site-Directed Inhibitors of Prolyl Oligopeptidase Abolish Its Conformational Dynamics [PDF]

, 2016
Deciphering conformational dynamics is crucial for understanding the biological functions of proteins and for designing compounds targeting them. In particular, providing an accurate description of microsecond–millisecond motions opens the opportunity ...
Bernadó, Bernadó, Boehr, Brandt, Canning, Cunningham, Delaglio, Di Daniel, Fülöp, Gelis, Henzler-Wildman, Hornak, Jacques, Jaeger, Jorgensen, Kaszuba, Kichik, Konarev, Korzhnev, Li, Mertens, Mulder, Myöhänen, Nevola, Palmer, Religa, Savolainen, Savolainen, Shan, Svergun, Svergun, Tarragó, Tugarinov, Venäläinen, Yoshimoto   +34 more
core   +3 more sources

Changements hématologique et biochimique dans la trypanosomose humaine et animale

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1988
Les trypanosomoses se caractérisent, en général, par de l’anémie, de la leucopénie, de la thrombocytopénie, ainsi que par des troubles du métabolisme d’où résultent de l’hypoglycémie, une élévation du taux d’azote uréique du sang, de l’hypoalbuminémie ...
V.O. Anosa
doaj   +1 more source