Results 71 to 80 of about 1,093 (175)
iScience, 2020 Summary: Molecular components that are functionally interdependent in human cells constitute molecular association networks. Disease can be caused by disturbance of multiple molecular interactions.
Hai-Cheng Yi +5 more
doaj +1 more source
aKmerBroom: Ancient oral DNA decontamination using Bloom filters on k-mer sets
iScience, 2023 Summary: Dental calculus samples are modeled as a mixture of DNA coming from dental plaque and contaminants. Current computational decontamination methods such as Recentrifuge and DeconSeq require either a reference database or sequenced negative ...
Camila Duitama González +4 more
doaj +1 more source
Structural aspects of the Huntingtin protein investigated by biocomputing methods
, 2011 Huntington’s disease (HD) is a neurodegenerative disorder which leads to death within a couple of decades. It causes uncontrolled movements, loss of intellectual faculties and emotional disturbance. HD is a familial disease, passed from parent to child through a mutation in a specific gene, the HTT gene. This gene provides the genetic information for a
openaire +2 more sources
Respiratory, postural and spatio-kinetic motor stabilization, internal models, top-down timed motor coordination and expanded cerebello-cerebral circuitry: a review [PDF]
, 2008 Human dexterity, bipedality, and song/speech vocalization in Homo are reviewed within a motor evolution perspective in regard to (i) brain expansion in cerebello-cerebral circuitry, (ii) enhanced predictive internal modeling
John R. Skoyles
core +2 more sources
Using active learning methodologies to teach sequence analysis and molecular phylogeny
Biochemistry and Molecular Biology Education, Volume 53, Issue 1, Page 21-32, January/February 2025.Abstract The great development of high‐throughput molecular biology techniques and the consequent generation of massive data have made Bioinformatics essential for undergraduate Bioscience students. The importance of this scientific discipline is evidenced by the huge number of specialized publications, tools, and databases available.
Inmaculada Ortiz Martín +3 more
wiley +1 more source
iScience, 2022 Summary: Biomechanical signals from remodeled extracellular matrix (ECM) promote tumor progression. Here, we show that cell-matrix and cell-cell communication may be inherently linked and tuned through mechanisms of mechanosensitive biogenesis of ...
Kshitiz Parihar +4 more
doaj +1 more source
Modeling dopaminergic and other processes involved in learning from reward prediction error: contributions from an individual differences perspective [PDF]
, 2014 Phasic firing changes of midbrain dopamine neurons have been widely characterized as reflecting a reward prediction error (RPE). Major personality traits (e.g., extraversion) have been linked to inter-individual variations in dopaminergic ...
Alan D. Pickering, Francesca Pesola
core +2 more sources
Ymir: A 3D structural affinity model for multi-epitope vaccine simulations
iScience, 2021 Summary: Vaccine development is challenged by the hierarchy of immunodominance between target antigen epitopes and the emergence of antigenic variants by pathogen mutation.
Philippe A. Robert +2 more
doaj +1 more source
Molecular Oncology, Volume 18, Issue 10, Page 2524-2540, October 2024.The machinery that carries out maturation of RNA, the spliceosome, is severely altered in pancreatic ductal adenocarcinoma. Decreased expression of two splicing factors, PRPF8 and RBMX, is linked to aggressiveness features and poor survival, while their rescue improves cell behavior.
Emilia Alors‐Pérez +19 more
wiley +1 more source
Cancer Science, Volume 115, Issue 9, Page 2893-2907, September 2024.Our study successfully identified a specific signature for CAFs within prostate cancer (PCa). We established that CAFs are linked to PCa progression, higher Gleason scores, and CRPC. The significance of CAFs in PCa was further underscored by their maintenance of high signal output post‐ADT and the stable gene signature.
Shen Pan +5 more
wiley +1 more source