Results 41 to 50 of about 2,351 (208)
GOing Forward With the Cardiac Conduction System Using Gene Ontology
Frontiers in Genetics, 2022 The cardiac conduction system (CCS) comprises critical components responsible for the initiation, propagation, and coordination of the action potential. Aberrant CCS development can cause conduction abnormalities, including sick sinus syndrome, accessory
Kan Yan Chloe Li +3 more
doaj +1 more source
Term Matrix: a novel Gene Ontology annotation quality control system based on ontology term co-annotation patterns [PDF]
Open Biology, 2020 Biological processes are accomplished by the coordinated action of gene products. Gene products often participate in multiple processes, and can therefore be annotated to multiple Gene Ontology (GO) terms.
Valerie Wood +13 more
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Exploring Manually Curated Annotations of Intrinsically Disordered Proteins with DisProt
Current Protocols, Volume 2, Issue 7, July 2022., 2022 Abstract DisProt is the major repository of manually curated data for intrinsically disordered proteins collected from the literature. Although lacking a stable three‐dimensional structure under physiological conditions, intrinsically disordered proteins carry out a plethora of biological functions, some of them directly arising from their flexible ...
Federica Quaglia +4 more
wiley +1 more source
The FEBS Journal, Volume 289, Issue 14, Page 4240-4250, July 2022., 2022 Intrinsically disordered regions (IDRs) are abundant in the SARS‐CoV‐2 spike glycoprotein S1 subunit and nucleoprotein. Mutations occurring in the 13 main variants, including Omicron, correlate with these IDRs and play a role in immune evasion. Moreover, IDRs in the major antigenic site of the spike glycoprotein suggest a role of intrinsic disorder in ...
Federica Quaglia +5 more
wiley +1 more source
ECO-CollecTF: A Corpus of Annotated Evidence-Based Assertions in Biomedical Manuscripts
Frontiers in Research Metrics and Analytics, 2021 Analysis of high-throughput experiments in the life sciences frequently relies upon standardized information about genes, gene products, and other biological entities.
Elizabeth T. Hobbs +14 more
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Metabolites, 2021 The UniProt Knowledgebase UniProtKB is a comprehensive, high-quality, and freely accessible resource of protein sequences and functional annotation that covers genomes and proteomes from tens of thousands of taxa, including a broad range of plants and ...
Marc Feuermann +18 more
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Alzheimer's &Dementia, Volume 18, Issue 4, Page 612-624, April 2022., 2022 Abstract Introduction Plasma proteins affect biological processes and are common drug targets but their role in the development of Alzheimer's disease and related dementias remains unclear. We examined associations between 4953 plasma proteins and cognitive decline and risk of dementia in two cohort studies with 20‐year follow‐ups.
Joni V. Lindbohm +14 more
wiley +1 more source
An Evidence‐Based Framework for Evaluating Pharmacogenomics Knowledge for Personalized Medicine
Clinical Pharmacology &Therapeutics, Volume 110, Issue 3, Page 563-572, September 2021., 2021 Clinical annotations are one of the most popular resources available on the Pharmacogenomics Knowledgebase (PharmGKB). Each clinical annotation summarizes the association between variant‐drug pairs, shows relevant findings from the curated literature, and is assigned a level of evidence (LOE) to indicate the strength of support for that association ...
Michelle Whirl‐Carrillo +6 more
wiley +1 more source
Current Protocols, Volume 1, Issue 7, July 2021., 2021 Abstract The Protein Ensemble Database (PED; https://proteinensemble.org/) is the major repository of conformational ensembles of intrinsically disordered proteins (IDPs). Conformational ensembles of IDPs are primarily provided by their authors or occasionally collected from literature, and are subsequently deposited in PED along with the corresponding
Federica Quaglia +5 more
wiley +1 more source