Results 31 to 40 of about 1,082 (162)

John D. Westbrook Jr (1957–2021)

Acta Crystallographica Section D, Volume 77, Issue 11, Page 1475-1476, November 2021., 2021
John Westbrook is remembered.John Westbrook is remembered.
Christine Zardecki, Stephen K. Burley
wiley   +1 more source

An Evidence‐Based Framework for Evaluating Pharmacogenomics Knowledge for Personalized Medicine

Clinical Pharmacology &Therapeutics, Volume 110, Issue 3, Page 563-572, September 2021., 2021
Clinical annotations are one of the most popular resources available on the Pharmacogenomics Knowledgebase (PharmGKB). Each clinical annotation summarizes the association between variant‐drug pairs, shows relevant findings from the curated literature, and is assigned a level of evidence (LOE) to indicate the strength of support for that association ...
Michelle Whirl‐Carrillo, Rachel Huddart, Li Gong, Katrin Sangkuhl, Caroline F. Thorn, Ryan Whaley, Teri E. Klein   +6 more
wiley   +1 more source

The future of annotation/biocuration [PDF]

Nature Precedings, 2009
AbstractTalk given at 3rd International Biocuration Conference.
Amos Bairoch, Amos Bairoch
openaire   +2 more sources

Exploring Curated Conformational Ensembles of Intrinsically Disordered Proteins in the Protein Ensemble Database

Current Protocols, Volume 1, Issue 7, July 2021., 2021
Abstract The Protein Ensemble Database (PED; https://proteinensemble.org/) is the major repository of conformational ensembles of intrinsically disordered proteins (IDPs). Conformational ensembles of IDPs are primarily provided by their authors or occasionally collected from literature, and are subsequently deposited in PED along with the corresponding
Federica Quaglia, Tamas Lazar, András Hatos, Peter Tompa, Damiano Piovesan, Silvio C. E. Tosatto   +5 more
wiley   +1 more source

A crowdsourcing open platform for literature curation in UniProt.

PLoS Biology, 2021
The UniProt knowledgebase is a public database for protein sequence and function, covering the tree of life and over 220 million protein entries. Now, the whole community can use a new crowdsourcing annotation system to help scale up UniProt curation and
Yuqi Wang, Qinghua Wang, Hongzhan Huang, Wei Huang, Yongxing Chen, Peter B McGarvey, Cathy H Wu, Cecilia N Arighi, UniProt Consortium   +8 more
doaj   +1 more source

Text mining for the biocuration workflow [PDF]

Database, 2012
Molecular biology has become heavily dependent on biological knowledge encoded in expert curated biological databases. As the volume of biological literature increases, biocurators need help in keeping up with the literature; (semi-) automated aids for biocuration would seem to be an ideal application for natural language processing and text mining ...
Lynette Hirschman, Gully A. P. C. Burns, Martin Krallinger, Cecilia N. Arighi, K. Bretonnel Cohen, Alfonso Valencia, Cathy H. Wu, Andrew Chatr-aryamontri, Karen G. Dowell, Eva Huala, Anália Lourenço, Robert S. Nash, Anne-Lise Veuthey, Thomas C. Wiegers, Andrew G. Winter   +14 more
openaire   +4 more sources

APICURON: a database to credit and acknowledge the work of biocurators [PDF]

Database, 2021
Abstract APICURON is an open and freely accessible resource that tracks and credits the work of biocurators across multiple participating knowledgebases. Biocuration is essential to extract knowledge from research data and make it available in a structured and standardized way to the scientific community.
Hatos A., Quaglia F., Piovesan D., Tosatto S. C. E.   +3 more
openaire   +4 more sources

Hidden in plain sight: what remains to be discovered in the eukaryotic proteome? [PDF]

Open Biology, 2019
The first decade of genome sequencing stimulated an explosion in the characterization of unknown proteins. More recently, the pace of functional discovery has slowed, leaving around 20% of the proteins even in well-studied model organisms without ...
Valerie Wood, Antonia Lock, Midori A. Harris, Kim Rutherford, Jürg Bähler, Stephen G. Oliver   +5 more
doaj   +1 more source

Beyond gene ontology (GO): using biocuration approach to improve the gene nomenclature and functional annotation of rice S-domain kinase subfamily [PDF]

PeerJ, 2021
The S-domain subfamily of receptor-like kinases (SDRLKs) in plants is poorly characterized. Most members of this subfamily are currently assigned gene function based on the S-locus Receptor Kinase from Brassica that acts as the female determinant of self-
Sushma Naithani, Daemon Dikeman, Priyanka Garg, Noor Al-Bader, Pankaj Jaiswal   +4 more
doaj   +2 more sources

Biocuration Virtual Issue 2012 [PDF]

Database, 2012
Curated databases are a cornerstone of research in the life sciences providing essential encyclopedic-like reference information on genes, their products and interactions, nomenclature standards, reference genome sequences and their annotations. Research laboratories and experimental techniques rely on resources such as databases and bioinformatics ...
Pascale Gaudet, Raja Mazumder
openaire   +3 more sources