Frontiers in Genetics, 2012 Immunogenetics is the science that studies the genetics of the immune system and immune responses. Owing to the complexity and diversity of the immune repertoire, immunogenetics represents one of the greatest challenges for data interpretation: a large ...
Véronique Giudicelli +2 more
exaly +6 more sources
IMGT/StatClonotype for Pairwise Evaluation and Visualization of NGS IG and TR IMGT Clonotype (AA) Diversity or Expression from IMGT/HighV-QUEST [PDF]
Frontiers in Immunology, 2016 There is a huge need for standardized analysis and statistical procedures in order to compare the complex immune repertoires of antigen receptors immunoglobulins (IG) and T cell receptors (TR) obtained by next generation sequencing (NGS).
Patrice Duroux +2 more
exaly +5 more sources
Immunoglobulins: 25 Years of Immunoinformatics and IMGT-ONTOLOGY [PDF]
Biomolecules, 2014 IMGT®, the international ImMunoGeneTics information system® (CNRS and Montpellier University) is the global reference in immunogenetics and immunoinformatics.
Marie-Paule Lefranc +1 more
exaly +5 more sources
IMGT-ONTOLOGY and IMGT databases, tools and Web resources for immunogenetics and immunoinformatics [PDF]
Molecular Immunology, 2004 The international ImMunoGeneTics information system (IMGT; http://imgt.cines.fr), is a high quality integrated information system specialized in immunoglobulins (IG), T cell receptors (TR), major histocompatibility complex (MHC), and related proteins of the immune system (RPI) of human and other vertebrates, created in 1989, by the Laboratoire d ...
Marie-Paule Lefranc
exaly +15 more sources
IMGT-Kaleidoscope, the formal IMGT-ONTOLOGY paradigm [PDF]
Biochimie, 2008 IMGT, the international ImMunoGeneTics information system (http://imgt.cines.fr), is the reference in immunogenetics and immunoinformatics. IMGT standardizes and manages the complex immunogenetic data which include the immunoglobulins (IG) or antibodies, the T cell receptors (TR), the major histocompatibility complex (MHC) and the related proteins of ...
Patrice Duroux +2 more
exaly +6 more sources
IMGT® Nomenclature of Immunoglobulins (IG) or Antibodies and T Cell Receptors (TR): A Common Language for Immunoinformatics and Artificial Intelligence (AI) [PDF]
AntibodiesThe immunoglobulins (IG) or antibodies and the T cell receptors (TR) are the antigen receptors of the adaptive immune responses (AIR) of jawed vertebrates (Gnathostomata).
Marie-Paule Lefranc, Gérard Lefranc
doaj +2 more sources
Identification of engineered IMGT Fc variants in IMGT/mAb-DB, a database of therapeutic antibodies and fusion proteins [PDF]
mAbsMonoclonal antibodies (mAbs) and fusion proteins for immune applications (FPIA) play a crucial role in treating autoimmune diseases and cancers by targeting cell-surface proteins and triggering multiple immune mechanisms.
Taciana Manso +8 more
doaj +2 more sources
Therapeutic monoclonal antibodies repurposing in oncology via IMGT/mAb-KG embeddings [PDF]
BMC Medical Informatics and Decision MakingBackground Cancer remains one of the leading causes of mortality worldwide, accounting for approximately 9.7 million deaths in 2022. Faced with this significant public health challenge, therapeutic monoclonal antibodies (mAbs) have emerged as promising ...
Gaoussou Sanou +5 more
doaj +2 more sources
BioMedInformatics, 2023 Human immunoglobulin allotypes are allelic antigenic determinants (or “markers”) determined serologically, classically by hemagglutination inhibition, on the human immunoglobulin (IG) or antibody heavy and light chains. The allotypes have been identified
Marie-Paule Lefranc +2 more
exaly +3 more sources
From IMGT-ONTOLOGY to IMGT/LIGMotif: the IMGT® standardized approach for immunoglobulin and T cell receptor gene identification and description in large genomic sequences [PDF]
BMC Bioinformatics, 2010 Background The antigen receptors, immunoglobulins (IG) and T cell receptors (TR), are specific molecular components of the adaptive immune response of vertebrates.
Lefranc Marie-Paule +2 more
doaj +4 more sources