Results 1 to 10 of about 9,211 (171)

IMGT^® Nomenclature of Immunoglobulins (IG) or Antibodies and T Cell Receptors (TR): A Common Language for Immunoinformatics and Artificial Intelligence (AI)

Antibodies
The immunoglobulins (IG) or antibodies and the T cell receptors (TR) are the antigen receptors of the adaptive immune responses (AIR) of jawed vertebrates (Gnathostomata).
Marie-Paule Lefranc, Gérard Lefranc
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TR Locus Annotation and Characteristics of Rhinolophus ferrumequinum

Frontiers in Immunology, 2021
T-cell antigen receptors (TRs) in vertebrates can be divided into αβ or γδ, encoded by TRA/D, TRG, or TRB loci. TRs play a central role in mammal cellular immunity, which occurs by rearrangement of V, D, J, and C genes in the loci.
Hao Zhou, Long Ma, Longyu Liu, Xinsheng Yao   +3 more
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Therapeutic monoclonal antibodies repurposing in oncology via IMGT/mAb-KG embeddings

BMC Medical Informatics and Decision Making
Background Cancer remains one of the leading causes of mortality worldwide, accounting for approximately 9.7 million deaths in 2022. Faced with this significant public health challenge, therapeutic monoclonal antibodies (mAbs) have emerged as promising ...
Gaoussou Sanou, Taciana Manso, Konstantin Todorov, Véronique Giudicelli, Patrice Duroux, Sofia Kossida   +5 more
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Lipid Droplets Are a Physiological Nucleoporin Reservoir

Cells, 2021
Lipid Droplets (LD) are dynamic organelles that originate in the Endoplasmic Reticulum and mostly bud off toward the cytoplasm, where they store neutral lipids for energy and protection purposes.
Sylvain Kumanski, Benjamin T. Viart, Sofia Kossida, María Moriel-Carretero   +3 more
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IMGT/GeneInfo: T cell receptor gamma TRG and delta TRD genes in database give access to all TR potential V(D)J recombinations

BMC Bioinformatics, 2006
Background Adaptative immune repertoire diversity in vertebrate species is generated by recombination of variable (V), diversity (D) and joining (J) genes in the immunoglobulin (IG) loci of B lymphocytes and in the T cell receptor (TR) loci of T ...
Jouvin-Marche Evelyne, Lefranc Marie-Paule, Chaume Denys, Bellahcene Fatena, Pasqual Nicolas, Hierle Vivien, Baum Thierry-Pascal, Marche Patrice, Demongeot Jacques   +8 more
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Inferred Allelic Variants of Immunoglobulin Receptor Genes: A System for Their Evaluation, Documentation, and Naming

Frontiers in Immunology, 2019
Immunoglobulins or antibodies are the main effector molecules of the B-cell lineage and are encoded by hundreds of variable (V), diversity (D), and joining (J) germline genes, which recombine to generate enormous IG diversity.
Mats Ohlin, Cathrine Scheepers, Cathrine Scheepers, Martin Corcoran, William D. Lees, Christian E. Busse, Davide Bagnara, Linnea Thörnqvist, Jean-Philippe Bürckert, Katherine J. L. Jackson, Duncan Ralph, Chaim A. Schramm, Nishanth Marthandan, Felix Breden, Jamie Scott, Frederick A. Matsen IV, Victor Greiff, Gur Yaari, Steven H. Kleinstein, Scott Christley, Jacob S. Sherkow, Sofia Kossida, Marie-Paule Lefranc, Menno C. van Zelm, Corey T. Watson, Andrew M. Collins   +25 more
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Standardized IMGT® Nomenclature of Salmonidae IGH Genes, the Paradigm of Atlantic Salmon and Rainbow Trout: From Genomics to Repertoires

Frontiers in Immunology, 2019
In teleost fish as in mammals, humoral adaptive immunity is based on B lymphocytes expressing highly diverse immunoglobulins (IG). During B cell differentiation, IG loci are subjected to genomic rearrangements of V, D, and J genes, producing a unique ...
Susana Magadan, Susana Magadan, Aleksei Krasnov, Saida Hadi-Saljoqi, Sergey Afanasyev, Stanislas Mondot, Delphine Lallias, Rosario Castro, Irene Salinas, Oriol Sunyer, John Hansen, Ben F. Koop, Marie-Paule Lefranc, Pierre Boudinot   +13 more
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Topology and expressed repertoire of the Felis catus T cell receptor loci

BMC Genomics, 2020
Background The domestic cat (Felis catus) is an important companion animal and is used as a large animal model for human disease. However, the comprehensive study of adaptive immunity in this species is hampered by the lack of data on lymphocyte antigen ...
Araya Radtanakatikanon, Stefan M. Keller, Nikos Darzentas, Peter F. Moore, Géraldine Folch, Viviane Nguefack Ngoune, Marie-Paule Lefranc, William Vernau   +7 more
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A Streamlined Approach to Antibody Novel Germline Allele Prediction and Validation

Frontiers in Immunology, 2017
Advancements in high-throughput sequencing and molecular identifier-based error correction have opened the door to antibody repertoire sequencing with single mutation precision, increasing both the breadth and depth of immune response characterization ...
Ben S. Wendel, Chenfeng He, Peter D. Crompton, Susan K. Pierce, Ning Jiang, Ning Jiang   +5 more
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下一代测序鉴定新等位基因HLA-DQB1*04:74和HLA-DRB1*07:01:23序列及家系调查

Zhongguo shiyan zhenduanxue, 2021
人类对主要组织相容性复合物(MHC)的研究起源于同种异体组织器官移植和移植物的急性排斥反应。人类的MHC称为白细胞抗原(HLA)系统。HLA主要的遗传特征是共显性、多基因性和极度丰富的多态性。1958年第一个HLA抗原被检出,经过数十年的发展,相关工作者一直努力应对HLA不断扩大的等位基因数量。截至2020年4月更新的国际免疫遗传IMGT/HLA数据库3.40.0版(http//:www.ebi.ac.uk/imgt/hla/stats.html)显示,共计发现HLA-A座位等位基因6082种,
武君华, 王满妮, 王天菊, 王小芳, 尚利侠, 陈乐, 房婕, 齐珺   +7 more
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