IMGT® Nomenclature of Immunoglobulins (IG) or Antibodies and T Cell Receptors (TR): A Common Language for Immunoinformatics and Artificial Intelligence (AI) [PDF]
AntibodiesThe immunoglobulins (IG) or antibodies and the T cell receptors (TR) are the antigen receptors of the adaptive immune responses (AIR) of jawed vertebrates (Gnathostomata).
Marie-Paule Lefranc, Gérard Lefranc
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Identification of engineered IMGT Fc variants in IMGT/mAb-DB, a database of therapeutic antibodies and fusion proteins [PDF]
mAbsMonoclonal antibodies (mAbs) and fusion proteins for immune applications (FPIA) play a crucial role in treating autoimmune diseases and cancers by targeting cell-surface proteins and triggering multiple immune mechanisms.
Taciana Manso +8 more
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Therapeutic monoclonal antibodies repurposing in oncology via IMGT/mAb-KG embeddings [PDF]
BMC Medical Informatics and Decision MakingBackground Cancer remains one of the leading causes of mortality worldwide, accounting for approximately 9.7 million deaths in 2022. Faced with this significant public health challenge, therapeutic monoclonal antibodies (mAbs) have emerged as promising ...
Gaoussou Sanou +5 more
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Immunoglobulins: 25 Years of Immunoinformatics and IMGT-ONTOLOGY
Biomolecules, 2014 IMGT®, the international ImMunoGeneTics information system® (CNRS and Montpellier University) is the global reference in immunogenetics and immunoinformatics.
Marie-Paule Lefranc +1 more
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Frontiers in Immunology, 2016 There is a huge need for standardized analysis and statistical procedures in order to compare the complex immune repertoires of antigen receptors immunoglobulins (IG) and T cell receptors (TR) obtained by next generation sequencing (NGS).
Véronique Giudicelli +2 more
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Frontiers in Genetics, 2012 Immunogenetics is the science that studies the genetics of the immune system and immune responses. Owing to the complexity and diversity of the immune repertoire, immunogenetics represents one of the greatest challenges for data interpretation: a large ...
Véronique Giudicelli +2 more
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Advances in MICA genotyping: characterization of 406 novel alleles and their frequencies in multiple populations [PDF]
Frontiers in ImmunologyIn 2020, we reported MICA allele frequencies from a cohort of over one million German individuals. This study identified MICA*008 (42%), MICA*002 (12%), and MICA*009 (9%) as the most common MICA alleles at protein resolution.
Viviane Albrecht +8 more
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The evolutionary history of IGKC in mammals reveals ancient duplications and remarkable divergence in lagomorphs [PDF]
Frontiers in ImmunologyBackgroundThe Immunoglobulin Kappa Constant (IGKC) gene encodes the constant region of the immunoglobulin kappa light chain, a crucial component of antibodies.
Ana Pinheiro +10 more
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From benchmarking alignment of genome assemblies to IMGT annotation: the paradigm of the bovine Bos taurus T cell receptor (TRG) locus [PDF]
BMC GenomicsT cell receptors (TR) are essential components of the adaptive immune system, typically classified into αβ and γδ types. In humans and mice, αβ T cells predominate, with γδ T cells comprising only a small percentage of the total T cell population.
Hao Zhou +5 more
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Three-Dimensional Modeling of Camelus dromedarius T Cell Receptor Gamma (TRG)_Delta (TRD)/CD1D Complex Reveals Different Binding Interactions Depending on the TRD CDR3 Length [PDF]
AntibodiesBackground: In the adaptive immune response of the dromedary (Camelus dromedarius, Camdro), the T cell receptor (TR) repertoire of the gamma–delta (γδ) T cells is unusually diversified both by somatic hypermutation in rearranged TR gamma (TRG) and delta (
Salvatrice Ciccarese +4 more
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