Results 21 to 30 of about 8,108 (168)

IMGT/HighV-QUEST Statistical Significance of IMGT Clonotype (AA) Diversity per Gene for Standardized Comparisons of Next Generation Sequencing Immunoprofiles of Immunoglobulins and T Cell Receptors. [PDF]

PLoS ONE, 2015
The adaptive immune responses of humans and of other jawed vertebrate species (gnasthostomata) are characterized by the B and T cells and their specific antigen receptors, the immunoglobulins (IG) or antibodies and the T cell receptors (TR) (up to 2.1012
Safa Aouinti, Dhafer Malouche, Véronique Giudicelli, Sofia Kossida, Marie-Paule Lefranc   +4 more
doaj   +1 more source

IMGT^® Nomenclature of Engineered IGHG Variants Involved in Antibody Effector Properties and Formats

Antibodies, 2022
The constant region of the immunoglobulin (IG) or antibody heavy gamma chain is frequently engineered to modify the effector properties of the therapeutic monoclonal antibodies.
Marie-Paule Lefranc, Gérard Lefranc
doaj   +1 more source

Ultrasound-Responsive Liposomes for Targeted Drug Delivery Combined with Focused Ultrasound

Pharmaceutics, 2022
Chemotherapeutic drugs are traditionally used for the treatment of cancer. However, chemodrugs generally induce side effects and decrease anticancer effects due to indiscriminate diffusion and poor drug delivery.
Yoon-Seok Kim, Min Jung Ko, Hyungwon Moon, Wonchul Sim, Ae Shin Cho, Gio Gil, Hyun Ryoung Kim   +6 more
doaj   +1 more source

Mechanisms of action of monoclonal antibodies in oncology integrated in IMGT/mAb-DB

Frontiers in Immunology, 2023
BackgroundCancer cells activate different immune checkpoint (IC) pathways in order to evade immunosurveillance. Immunotherapies involving ICs either block or stimulate these pathways and enhance the efficiency of the immune system to recognize and attack
Taciana Manso, Anjana Kushwaha, Nika Abdollahi, Patrice Duroux, Véronique Giudicelli, Sofia Kossida   +5 more
doaj   +1 more source

The IPD-IMGT/HLA Database

Nucleic Acids Research, 2022
AbstractIt is 24 years since the IPD-IMGT/HLA Database, http://www.ebi.ac.uk/ipd/imgt/hla/, was first released, providing the HLA community with a searchable repository of highly curated HLA sequences. The database now contains over 35 000 alleles of the human Major Histocompatibility Complex (MHC) named by the WHO Nomenclature Committee for Factors of
Dominic J. Barker, Giuseppe Maccari, Xenia Georgiou, Michael A. Cooper, Paul Flicek, James Robinson, Steven G. E. Marsh   +6 more
openaire   +3 more sources

IMGT, the international ImMunoGeneTics database [PDF]

Nucleic Acids Research, 1997
IMGT, the international ImMunoGeneTics database, is an integrated database specializing in immunoglobulins, T-cell receptors (TcR) and major histocompatibility complex (MHC) of all vertebrate species, initiated and co-ordinated by Marie-Paule Lefranc, CNRS, Montpellier II University, Montpellier, France (lefranc@ligm.crbm.cnrs-mop.fr).
Marie-Paule Lefranc, Véronique Giudicelli, Chantal Ginestoux, Julia G. Bodmer, Werner Müller, Ronald Bontrop, Marc Lemaitre, Ansar Malik, Valérie Barbié, Denys Chaume   +9 more
openaire   +5 more sources

IPD-IMGT/HLA Database [PDF]

Nucleic Acids Research, 2019
AbstractThe IPD-IMGT/HLA Database, http://www.ebi.ac.uk/ipd/imgt/hla/, currently contains over 25 000 allele sequence for 45 genes, which are located within the Major Histocompatibility Complex (MHC) of the human genome. This region is the most polymorphic region of the human genome, and the levels of polymorphism seen exceed most other genes.
James Robinson, Dominic J. Barker, Xenia Georgiou, Michael A. Cooper, Paul Flicek, Steven G. E. Marsh   +5 more
openaire   +2 more sources

Delving into Molecular Pathways: Analyzing the Mechanisms of Action of Monoclonal Antibodies Integrated in IMGT/mAb-DB for Myasthenia Gravis

Vaccines, 2023
Background: Myasthenia Gravis (MG) is a rare autoimmune disease presenting with auto-antibodies that affect the neuromuscular junction. In addition to symptomatic treatment options, novel therapeutics include monoclonal antibodies (mAbs).
Rebecca Golfinopoulou, Véronique Giudicelli, Taciana Manso, Sofia Kossida   +3 more
doaj   +1 more source

IMGT/HLA and IMGT/MHC: sequence databases for the study of the major histocompatibility complex [PDF]

Nucleic Acids Research, 2003
The IMGT/HLA database (http://www.ebi.ac.uk/imgt/hla) has provided a centralized repository for the sequences of the alleles named by the WHO Nomenclature Committee for Factors of the HLA System for the past four years. Since its initial release the database has grown and is the primary source of information for the study of sequences of the human ...
James Robinson, Matthew J. Waller, Peter Parham, Natasja de Groot, Ronald Bontrop, Lorna J. Kennedy, Peter Stoehr, Steven G. E. Marsh   +7 more
openaire   +3 more sources

The IMGT/HLA and IPD databases [PDF]

Human Mutation, 2006
The IMGT/HLA database (www.ebi.ac.uk/imgt/hla) has provided a centralized repository for the sequences of the alleles named by the WHO Nomenclature Committee for Factors of the HLA System since 1998. Since its initial release, the database has rapidly grown in size and is recognized as the primary source of information for the study of sequences of the
James, Robinson, Matthew J, Waller, Sylvie C, Fail, Steven G E, Marsh   +3 more
openaire   +4 more sources