Results 21 to 30 of about 9,211 (171)

IMGT^® Nomenclature of Engineered IGHG Variants Involved in Antibody Effector Properties and Formats

Antibodies, 2022
The constant region of the immunoglobulin (IG) or antibody heavy gamma chain is frequently engineered to modify the effector properties of the therapeutic monoclonal antibodies.
Marie-Paule Lefranc, Gérard Lefranc
doaj   +1 more source

Ultrasound-Responsive Liposomes for Targeted Drug Delivery Combined with Focused Ultrasound

Pharmaceutics, 2022
Chemotherapeutic drugs are traditionally used for the treatment of cancer. However, chemodrugs generally induce side effects and decrease anticancer effects due to indiscriminate diffusion and poor drug delivery.
Yoon-Seok Kim, Min Jung Ko, Hyungwon Moon, Wonchul Sim, Ae Shin Cho, Gio Gil, Hyun Ryoung Kim   +6 more
doaj   +1 more source

Mechanisms of action of monoclonal antibodies in oncology integrated in IMGT/mAb-DB

Frontiers in Immunology, 2023
BackgroundCancer cells activate different immune checkpoint (IC) pathways in order to evade immunosurveillance. Immunotherapies involving ICs either block or stimulate these pathways and enhance the efficiency of the immune system to recognize and attack
Taciana Manso, Anjana Kushwaha, Nika Abdollahi, Patrice Duroux, Véronique Giudicelli, Sofia Kossida   +5 more
doaj   +1 more source

Human Gm, Km, and Am Allotypes: WHO/IMGT Nomenclature and IMGT Unique Numbering for Immunoinformatics and Therapeutical Antibodies

BioMedInformatics, 2023
Human immunoglobulin allotypes are allelic antigenic determinants (or “markers”) determined serologically, classically by hemagglutination inhibition, on the human immunoglobulin (IG) or antibody heavy and light chains. The allotypes have been identified
Marie-Paule Lefranc, Gérard Lefranc
doaj   +1 more source

Delving into Molecular Pathways: Analyzing the Mechanisms of Action of Monoclonal Antibodies Integrated in IMGT/mAb-DB for Myasthenia Gravis

Vaccines, 2023
Background: Myasthenia Gravis (MG) is a rare autoimmune disease presenting with auto-antibodies that affect the neuromuscular junction. In addition to symptomatic treatment options, novel therapeutics include monoclonal antibodies (mAbs).
Rebecca Golfinopoulou, Véronique Giudicelli, Taciana Manso, Sofia Kossida   +3 more
doaj   +1 more source

Immunoglobulin (IG) and T cell receptor (TR) genes: IMGT® and the birth and rise of immunoinformatics

Frontiers in Immunology, 2014
IMGT®, the international ImMunoGeneTics information system®, http://www.imgt.org (CNRS and Université Montpellier 2) is the global reference in immunogenetics and immunoinformatics.
Marie-Paule eLefranc
doaj   +1 more source

IMGT/HighV QUEST paradigm for T cell receptor IMGT clonotype diversity and next generation repertoire immunoprofiling [PDF]

, 2013
T cell repertoire diversity and clonotype follow-up in vaccination, cancer, infectious and immune diseases represent a major challenge owing to the enormous complexity of the data generated.
Burrows, Scott R., Gowans, E., Corbin, Vincent D.A., Freeman, J Douglas, Papenfuss, Anthony, Scheerlinck, J. P., Burrows, S, Scheerlinck, J., Papenfuss, A., Papenfuss, A. T., Corbin, Vincent D. A., Alamyar, Eltaf, Burrows, SR, Freeman, J. Douglas, Corbin, Vincent, Duroux, P., Gowans, EJ, Papenfuss, Anthony, T., Miles, J., Freeman, J., Giudicelli, V., Burrows, Scott, Gowans, E. J., Gowans, E, Loveland, B, Giudicelli, Veronique, Papenfuss, AT, Miles, J. J., Corbin, Vincent, D. A., Freeman, JD, Li, S., Scheerlinck, Jean-Paul, Lefranc, M. P., Duroux, P, Cameron, Paul, U., Duroux, Patrice, Miles, JJ, Papenfuss, Anthony T., Lefranc, MP, Frohman, Michael A., Miles, John J., Cameron, PU, Plebanski, Magdalena, Scheerlinck, Jean-Pierre, Burrows, S. R., Gowans, Eric, Loveland, B., Alamyar, E., Lefranc, Marie-Paule, Corbin, VDA, Gowans, Eric J., Giudicelli, V, Scheerlinck, JP, Frohman, M. A., Lefranc, M., Burrows, Scott, R., Li, Shuo, Plebanski, M., Cameron, Paul U., Corbin, V. D., Loveland, Bruce, Freeman, John, Cameron, Paul, Frohman, MA, Corbin, V., Frohman, Michael, Plebanski, M, Burrows, S., Cameron, P., Cameron, P. U., Frohman, M., Miles, John, Freeman, J. D., Li, S, Alamyar, E   +74 more
core   +1 more source

Effects of Lipid Shape and Interactions on the Conformation, Dynamics, and Curvature of Ultrasound-Responsive Liposomes

Pharmaceutics, 2022
We perform coarse-grained molecular dynamics simulations of bilayers composed of various lipids and cholesterol at their different ratios. Simulations show that cholesterol-lipid interactions restrict the lateral dynamics of bilayers but also promote ...
Hwankyu Lee, Hyungwon Moon, Hyun-Ryoung Kim   +2 more
doaj   +1 more source

IMGT^® and 30 Years of Immunoinformatics Insight in Antibody V and C Domain Structure and Function

Antibodies, 2019
At the 10th Human Genome Mapping (HGM10) Workshop, in New Haven, for the first time, immunoglobulin (IG) or antibody and T cell receptor (TR) variable (V), diversity (D), joining (J), and constant (C) genes were officially recognized as ‘genes ...
Marie-Paule Lefranc, Gérard Lefranc
doaj   +1 more source

IMGT^® Biocuration and Analysis of the Rhesus Monkey IG Loci

Vaccines, 2022
The adaptive immune system, along with the innate immune system, are the two main biological processes that protect an organism from pathogens. The adaptive immune system is characterized by the specificity and extreme diversity of its antigen receptors.
Viviane Nguefack Ngoune, Morgane Bertignac, Maria Georga, Ariadni Papadaki, Alexandre Albani, Géraldine Folch, Joumana Jabado-Michaloud, Véronique Giudicelli, Patrice Duroux, Marie-Paule Lefranc, Sofia Kossida   +10 more
doaj   +1 more source