Results 31 to 40 of about 8,734 (193)

Mechanisms of action of monoclonal antibodies in oncology integrated in IMGT/mAb-DB

Frontiers in Immunology, 2023
BackgroundCancer cells activate different immune checkpoint (IC) pathways in order to evade immunosurveillance. Immunotherapies involving ICs either block or stimulate these pathways and enhance the efficiency of the immune system to recognize and attack
Taciana Manso, Anjana Kushwaha, Nika Abdollahi, Patrice Duroux, Véronique Giudicelli, Sofia Kossida   +5 more
doaj   +1 more source

IPD-IMGT/HLA Database [PDF]

Nucleic Acids Research, 2019
AbstractThe IPD-IMGT/HLA Database, http://www.ebi.ac.uk/ipd/imgt/hla/, currently contains over 25 000 allele sequence for 45 genes, which are located within the Major Histocompatibility Complex (MHC) of the human genome. This region is the most polymorphic region of the human genome, and the levels of polymorphism seen exceed most other genes.
James Robinson, Dominic J. Barker, Xenia Georgiou, Michael A. Cooper, Paul Flicek, Steven G. E. Marsh   +5 more
openaire   +2 more sources

Human Gm, Km, and Am Allotypes: WHO/IMGT Nomenclature and IMGT Unique Numbering for Immunoinformatics and Therapeutical Antibodies

BioMedInformatics, 2023
Human immunoglobulin allotypes are allelic antigenic determinants (or “markers”) determined serologically, classically by hemagglutination inhibition, on the human immunoglobulin (IG) or antibody heavy and light chains. The allotypes have been identified
Marie-Paule Lefranc, Gérard Lefranc
doaj   +1 more source

Delving into Molecular Pathways: Analyzing the Mechanisms of Action of Monoclonal Antibodies Integrated in IMGT/mAb-DB for Myasthenia Gravis

Vaccines, 2023
Background: Myasthenia Gravis (MG) is a rare autoimmune disease presenting with auto-antibodies that affect the neuromuscular junction. In addition to symptomatic treatment options, novel therapeutics include monoclonal antibodies (mAbs).
Rebecca Golfinopoulou, Véronique Giudicelli, Taciana Manso, Sofia Kossida   +3 more
doaj   +1 more source

Immunoglobulin (IG) and T cell receptor (TR) genes: IMGT® and the birth and rise of immunoinformatics

Frontiers in Immunology, 2014
IMGT®, the international ImMunoGeneTics information system®, http://www.imgt.org (CNRS and Université Montpellier 2) is the global reference in immunogenetics and immunoinformatics.
Marie-Paule eLefranc
doaj   +1 more source

IMGT® at scale: FAIR, dynamic, and automated tools for immune locus analysis. [PDF]

Nucleic Acids Res
International audienceIMGT ® , the international ImMunoGeneTics information system ® , has advanced its comprehensive platform for the analysis of immunoglobulin (IG) and T-cell receptor (TR) genes through the de v elopment of ne w automated and scalable
Sanou G, Zeitoun G, Manso T, Eidi M, Batool S, Kushwaha A, Grand F, Croze M, Vaillant A, Debbagh C, Abdollahi N, Georga M, Papadaki A, Sideri I, Samadova T, Jabado-Michaloud J, Folch G, Giudicelli V, Duroux P, Kossida S.   +19 more
europepmc   +2 more sources

IMGT, the international ImMunoGeneTics database [PDF]

Nucleic Acids Research, 2000
IMGT, the international ImMunoGeneTics database (http://imgt.cines. fr:8104 ), is a high-quality integrated database specialising in Immunoglobulins (Ig), T cell Receptors (TcR) and Major Histocompatibility Complex (MHC) molecules of all vertebrate species, created in 1989 by Marie-Paule Lefranc, Université Montpellier II, CNRS, Montpellier, France ...
Manuel Ruiz, Véronique Giudicelli, Chantal Ginestoux, Peter Stoehr, James Robinson, Julia G. Bodmer, Steven G. E. Marsh, Ronald Bontrop, Marc Lemaitre, Gérard Lefranc, Denys Chaume, Marie-Paule Lefranc   +11 more
openaire   +2 more sources

IMGT/HighV QUEST paradigm for T cell receptor IMGT clonotype diversity and next generation repertoire immunoprofiling [PDF]

, 2013
T cell repertoire diversity and clonotype follow-up in vaccination, cancer, infectious and immune diseases represent a major challenge owing to the enormous complexity of the data generated.
Burrows, Scott R., Gowans, E., Corbin, Vincent D.A., Freeman, J Douglas, Papenfuss, Anthony, Scheerlinck, J. P., Burrows, S, Scheerlinck, J., Papenfuss, A., Papenfuss, A. T., Corbin, Vincent D. A., Alamyar, Eltaf, Burrows, SR, Freeman, J. Douglas, Corbin, Vincent, Duroux, P., Gowans, EJ, Papenfuss, Anthony, T., Miles, J., Freeman, J., Giudicelli, V., Burrows, Scott, Gowans, E. J., Gowans, E, Loveland, B, Giudicelli, Veronique, Papenfuss, AT, Miles, J. J., Corbin, Vincent, D. A., Freeman, JD, Li, S., Scheerlinck, Jean-Paul, Lefranc, M. P., Duroux, P, Cameron, Paul, U., Duroux, Patrice, Miles, JJ, Papenfuss, Anthony T., Lefranc, MP, Frohman, Michael A., Miles, John J., Cameron, PU, Plebanski, Magdalena, Scheerlinck, Jean-Pierre, Burrows, S. R., Gowans, Eric, Loveland, B., Alamyar, E., Lefranc, Marie-Paule, Corbin, VDA, Gowans, Eric J., Giudicelli, V, Scheerlinck, JP, Frohman, M. A., Lefranc, M., Burrows, Scott, R., Li, Shuo, Plebanski, M., Cameron, Paul U., Corbin, V. D., Loveland, Bruce, Freeman, John, Cameron, Paul, Frohman, MA, Corbin, V., Frohman, Michael, Plebanski, M, Burrows, S., Cameron, P., Cameron, P. U., Frohman, M., Miles, John, Freeman, J. D., Li, S, Alamyar, E   +74 more
core   +1 more source

Effects of Lipid Shape and Interactions on the Conformation, Dynamics, and Curvature of Ultrasound-Responsive Liposomes

Pharmaceutics, 2022
We perform coarse-grained molecular dynamics simulations of bilayers composed of various lipids and cholesterol at their different ratios. Simulations show that cholesterol-lipid interactions restrict the lateral dynamics of bilayers but also promote ...
Hwankyu Lee, Hyungwon Moon, Hyun-Ryoung Kim   +2 more
doaj   +1 more source

IMGT^® and 30 Years of Immunoinformatics Insight in Antibody V and C Domain Structure and Function

Antibodies, 2019
At the 10th Human Genome Mapping (HGM10) Workshop, in New Haven, for the first time, immunoglobulin (IG) or antibody and T cell receptor (TR) variable (V), diversity (D), joining (J), and constant (C) genes were officially recognized as ‘genes ...
Marie-Paule Lefranc, Gérard Lefranc
doaj   +1 more source