Results 31 to 40 of about 9,211 (171)

Immunogenetic sequence annotation based on IMGT-ONTOLOGY [PDF]

, 2009
IMGT/LIGM-DB^1^ is the first and the largest IMGT^®^ database^2^ in which are managed, analysed and annotated more than 136,000 immunoglobulin (IG) and T cell receptor (TR) nucleotide sequences from human and 235 other vertebrate species (April 2009)
Fatena Bellahcene, Véronique Giudicelli, Marie-Paule Lefranc, Géraldine Folch, François Ehrenmann, Joumana Jabado-Michaloud, Géraldine Folch, Patrice Duroux, Joumana Jabado-Michaloud, François Ehrenmann, Véronique Giudicelli   +10 more
core   +1 more source

IMGT® Biocuration and Comparative Study of the T Cell Receptor Beta Locus of Veterinary Species Based on Homo sapiens TRB

Frontiers in Immunology, 2020
IMGT®, the international ImMunoGeneTics information system® is the global reference in immunogenetics and immunoinformatics. By its creation in 1989 by Marie-Paule Lefranc (Université de Montpellier and CNRS), IMGT® marked the advent of immunoinformatics,
Perrine Pégorier, Morgane Bertignac, Imène Chentli, Viviane Nguefack Ngoune, Géraldine Folch, Joumana Jabado-Michaloud, Saida Hadi-Saljoqi, Véronique Giudicelli, Patrice Duroux, Marie-Paule Lefranc, Sofia Kossida   +10 more
doaj   +1 more source

Haplotype Analysis of the T-Cell Receptor Beta (TCRB) Locus by Long-amplicon TCRB Repertoire Sequencing [PDF]

Journal of Immunotherapy and Precision Oncology, 2019
Background: Polymorphism within the human T-cell receptor beta variable (TRBV) gene has been proposed as a risk factor for autoimmune disease and immune-related adverse events (IRAEs) during immunotherapy.
Timothy J Looney, Dzifa Y Duose, Geoffrey Lowman, Elizabeth Linch, Joud Hajjar, Denise Topacio-Hall, Mingxuan Xu, Jianping Zheng, Anas Alshawa, Coya Tapia, Bettzy Stephen, Linghua Wang, Funda Meric-Bernstam, Lauren Miller, Alexander Glavin, Lifeng Lin, Jing Gong, Jeffrey Conroy, Carl Morrison, Fiona Hyland, Aung Naing   +20 more
doaj   +1 more source

IgMAT: immunoglobulin sequence multi-species annotation tool for any species including those with incomplete antibody annotation or unusual characteristics

BMC Bioinformatics, 2023
Background The advent and continual improvement of high-throughput sequencing technologies has made immunoglobulin repertoire sequencing accessible and informative regardless of study species. However, to fully map dynamic changes in polyclonal responses
Daniel Dorey-Robinson, Giuseppe Maccari, John A. Hammond   +2 more
doaj   +1 more source

IMGT, the international ImMunoGeneTics information system

, 2005
The international ImMunoGeneTics information system® (IMGT) (http://imgt.cines.fr), created in 1989, by the Laboratoire d'ImmunoGénétique Moléculaire LIGM (Université Montpellier II and CNRS) at Montpellier, France, is a high-quality integrated knowledge
Chaume, Denys, Duprat, Elodie, Jabado-Michaloud, Joumana, Ginestoux, Chantal, Giudicelli, V., Lefranc, Gerard, Lefranc, G., Scaviner, Dominique, Jabado-Michaloud, J., Clément, O., Clément, Oliver, Kaas, Quentin, Duprat, E., Scaviner, D., Giudicelli, Veronique, Ginestoux, C., Scaviner, Dominqiue, Kaas, Q., Chaume, D., Lefranc, Marie-Paule, Clément, Olivier   +20 more
core   +1 more source

IG and TR single chain fragment variable (scFv) sequence analysis: a new advanced functionality of IMGT/V-QUEST and IMGT/HighV-QUEST

BMC Immunology, 2017
Background IMGT®, the international ImMunoGeneTics information system® ( http://www.imgt.org ), was created in 1989 in Montpellier, France (CNRS and Montpellier University) to manage the huge and complex diversity of the antigen receptors, and is at the ...
Véronique Giudicelli, Patrice Duroux, Sofia Kossida, Marie-Paule Lefranc   +3 more
doaj   +1 more source

PD-L1 Targeting Immune-Microbubble Complex Enhances Therapeutic Index in Murine Colon Cancer Models

Pharmaceuticals, 2020
Cancer immunotherapy has revolutionized the way different neoplasms are treated. Among the different variations of cancer immunotherapy, the checkpoint inhibitors targeting the programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) axis
Daehyun Kim, Seung Soo Lee, Hyungwon Moon, So Yeon Park, Hak Jong Lee   +4 more
doaj   +1 more source

IMGT-ONTOLOGY

, 2013
International audienceIMGT-ONTOLOGY is the ontology for immunogenetics and immunoinformatics. IMGT-ONTOLOGY, created to manage the complexity of immunogenetics knowledge, is the first ontology and global reference in the domain.
Marie-Paule Lefranc, Giudicelli, Véronique, Véronique Giudicelli, Lefranc, Marie-Paule   +3 more
core   +1 more source

Identification of engineered IMGT Fc variants in IMGT/mAb-DB, a database of therapeutic antibodies and fusion proteins

mAbs
Monoclonal antibodies (mAbs) and fusion proteins for immune applications (FPIA) play a crucial role in treating autoimmune diseases and cancers by targeting cell-surface proteins and triggering multiple immune mechanisms.
Taciana Manso, Gaoussou Sanou, Christos Nousias, Imene Maalem, François Boutin, Véronique Giudicelli, Patrice Duroux, Marie-Paule Lefranc, Sofia Kossida   +8 more
doaj   +1 more source

Recovering probabilities for nucleotide trimming processes for T cell receptor TRA and TRG V-J junctions analyzed with IMGT tools

BMC Bioinformatics, 2008
Background Nucleotides are trimmed from the ends of variable (V), diversity (D) and joining (J) genes during immunoglobulin (IG) and T cell receptor (TR) rearrangements in B cells and T cells of the immune system. This trimming is followed by addition of
Lefranc Marie-Paule, Bleakley Kevin, Biau Gérard   +2 more
doaj   +1 more source