Results 51 to 60 of about 8,734 (193)

Examining variable domain orientations in antigen receptors gives insight into TCR-like antibody design. [PDF]

PLoS Computational Biology, 2014
The variable domains of antibodies and T-Cell receptors (TCRs) share similar structures. Both molecules act as sensors for the immune system but recognise their respective antigens in different ways.
James Dunbar, Bernhard Knapp, Angelika Fuchs, Jiye Shi, Charlotte M Deane   +4 more
doaj   +1 more source

Discovery and Structural Characterization of a Highly Protective Neutralizing Antibody Targeting the Mpox Virus A35R Protein

MedComm, Volume 7, Issue 7, July 2026.
High‐affinity monoclonal antibodies (mAbs) targeting the MPXV EEV protein A35R were rapidly isolated using mRNA‐LNP vaccination and the Beacon single‐cell sorting Optofluidic platform, followed by functional profiling. One mAb, 17H1, potently neutralized authentic MPXV and conferred complete protection in vivo.
Shimeng Bai, Shuo Song, Xin Wang, Yuxin Xiao, Yun Long, Fenfang Wu, Fuxiang Wang, Zhongyi Fan, Jianqing Xu, Maozhou He, Hongzhou Lu   +10 more
wiley   +1 more source

An Aging Clock Based on Immune Repertoire Features: COVID‐19 Accelerates Aging

Aging Cell, Volume 25, Issue 7, July 2026.
We systematically profiled TCR/BCR repertoires in Chinese individuals and paired COVID‐19 samples, revealed aging‐driven remodeling and COVID‐accelerated immune senescence, and built a reliable immune repertoire aging clock for immune senescence evaluation.
Xin Gao, Si‐Jia Li, Jin Li, Zi‐Hui Wang, Lv‐Tao Zeng, Ya‐Qing Ma, Ya‐Min Dang, Ying‐Min Zhang, Hong‐Lei Liu, Li‐Qun Zhang, Jing Pang, Ju Cui, Tie‐Mei Zhang, Jian‐Ping Cai   +13 more
wiley   +1 more source

Coupling of Single Molecule, Long Read Sequencing with IMGT/HighV-QUEST Analysis Expedites Identification of SIV gp140-Specific Antibodies from scFv Phage Display Libraries

Frontiers in Immunology, 2018
The simian immunodeficiency virus (SIV)/macaque model of human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome pathogenesis is critical for furthering our understanding of the role of antibody responses in the prevention of HIV infection,
Seung Yub Han, Alesia Antoine, David Howard, Bryant Chang, Woo Sung Chang, Matthew Slein, Gintaras Deikus, Sofia Kossida, Patrice Duroux, Marie-Paule Lefranc, Robert P. Sebra, Melissa L. Smith, Ismael Ben F. Fofana   +12 more
doaj   +1 more source

Full‐Length Next‐Generation Sequencing of 11 HLA Loci of More Than 1000 Individuals From Clinical Cohorts in East and West Africa

HLA, Volume 108, Issue 1, July 2026.
ABSTRACT HLA loci have been implicated in several diseases, including HIV‐1, from different world populations. It is necessary to characterise HLA allele variation at the population level prior to investigating associations linked to human diseases. In global databases, limited high‐resolution HLA allele types generated by next‐generation sequencing ...
Yvonne V. Rosario, Aviva Geretz, Lakshmi Rani Iyer, Philip K. Ehrenberg, Alýa Tyson, Hannah Kibuuka, Fred Wabwire‐Mangen, Lucas Maganga, Abdulwasiu Tiamiyu, Jonah Maswai, Josphat Kosgei, Frederick Sawe, Gary R. Matyas, Merlin L. Robb, Julie A. Ake, Rasmi Thomas   +15 more
wiley   +1 more source

Evolution of T cell receptor beta loci in salmonids

Frontiers in Immunology, 2023
T-cell mediated immunity relies on a vast array of antigen specific T cell receptors (TR). Characterizing the structure of TR loci is essential to study the diversity and composition of T cell responses in vertebrate species.
Pierre Boudinot, Samuel Novas, Luc Jouneau, Stanislas Mondot, Marie-Paule Lefranc, Unni Grimholt, Susana Magadán   +6 more
doaj   +1 more source

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, Volume 13, Issue 35, 24 June 2026.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

The Steroidal Profile Modulates Adaptive Immune Response and Prognosis in Adrenocortical Carcinoma: Analysis of TCR and BCR Repertoires

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Adrenocortical carcinoma (ACC) is a rare and aggressive malignant neoplasm with limited therapeutic options and an often poor prognosis. A deeper understanding of its interaction with the immune system is essential for the advancement of personalized treatment strategies, particularly in light of the tumor heterogeneity of hormone production ...
Jean Silva de Souza Resende, Igor Samesima Giner, João Carlos Degraf Muzzi, José Alexandre Marzagão Barbuto, Enzo Lalli, Mauro Antônio Alves Castro, Bonald Cavalcante de Figueiredo   +6 more
wiley   +1 more source

From IMGT-ONTOLOGY DESCRIPTION Axiom to IMGT Standardized Labels: For Immunoglobulin (IG) and T Cell Receptor (TR) Sequences and Structures

, 2011
INTRODUCTIONMore than 560 IMGT standardized labels have been defined for the description of immunoglobulin (IG) and T cell receptor (TR) sequences and structures.
Marie-Paule Lefranc, Lefranc, Mp
core   +1 more source

IMGT®, biocuration of IG and TR in IMGT/LIGM-DB and IMGT/GENE-DB

, 2016
IMGT®, the international ImMunoGeneTics information system, http://www.imgt.org , is the global reference in immunogenetics and immunoinformatics. By managing the extreme diversity and complexity of the antigen receptors of the adaptive immune response, the immunoglobulins (IG) or antibodies and ...
Folch, Géraldine, Jabado-Michaloud, Joumana, Peralta, Marine, Arrivet, Mélanie, Imène Chentli, Cambon, Mélissa, Bento, Pascal, Souphatta Sasorith, Paysan-Lafosse, Typhaine, Duroux, Patrice, Giudicelli, Véronique, Kossida, Sofia, Marie-Paule Lefranc   +12 more
openaire   +1 more source