Results 51 to 60 of about 8,108 (168)

Multiomics Insights Into AL Amyloidosis

Medicine Bulletin, EarlyView.
ABSTRACT Light chain amyloidosis is a systemic or localized protein conformational disorder triggered by misfolded immunoglobulin light chains, leading to amyloid fibril deposition. The disease is characterized by multiorgan involvement and delayed diagnosis, contributing to poor prognosis and high mortality rates.
Zixuan Zhang, Ziru Huang, Haoxiang Tang, Xianrun Pan, Rong Wang, Dingding Zhang, Jian Huang   +6 more
wiley   +1 more source

Evolution of T cell receptor beta loci in salmonids

Frontiers in Immunology, 2023
T-cell mediated immunity relies on a vast array of antigen specific T cell receptors (TR). Characterizing the structure of TR loci is essential to study the diversity and composition of T cell responses in vertebrate species.
Pierre Boudinot, Samuel Novas, Luc Jouneau, Stanislas Mondot, Marie-Paule Lefranc, Unni Grimholt, Susana Magadán   +6 more
doaj   +1 more source

Immune Repertoire Profiling Reveals Distinct Adaptive Immune Signatures of Dampness ZHENG Across Psoriasis, Rheumatoid Arthritis and Ulcerative Colitis

Cell Proliferation, EarlyView.
Schematic diagram for the experimental design for adaptome immune repertoire analysing Dampness ZHENG across Psoriasis, Rheumatoid Arthritis and Ulcerative Colitis. ABSTRACT Autoimmune diseases, including psoriasis (Ps), rheumatoid arthritis (RA) and ulcerative colitis (UC), pose significant health burdens worldwide.
Lipeng Tang, Maojie Wang, Yuhong Yan, Shumin Qin, Youbang Liang, Danni Yao, Liyan Mei, Hao Deng, Shuyan Ye, Xiumin Chen, Kaixin Gao, Xirun Zheng, Taohua Liu, Xinmin Qiu, Song Li, Xinjie Yu, Wenjing Pan, Shaogang Huang, Zhe Wang, Runyue Huang, Guangjuan Zheng, Chuanjian Lu   +21 more
wiley   +1 more source

Optimization of antibody binding by adjusting thermodynamic stability during the maturation of antibody affinities

Protein Science, Volume 35, Issue 9, September 2026.
Abstract Somatic mutations and antibody clone selection occur in B‐cell hyper‐evolution over extremely brief periods of time. Herein, we developed a technique for antibody screening by immunizing alpacas with antigens and observing antibody sequence transitions over time, a method we named Tracking the Evolution of Antibodies over time.
Yoko Akazawa‐Ogawa, Tomonari Matsuda, Norihiko Kiyose, Nobuo Miyazaki, Tetsuo Fukuta, Motoyasu Adachi, Yuji Ito, Yoshihisa Hagihara   +7 more
wiley   +1 more source

Single Cell and Spatially Resolved Transcriptome and Immune Repertoire of Mouse Thymus During Aging Reveal Immunological Heterogeneity and Direction of Thymic Selection Pressure

Aging Cell, Volume 25, Issue 8, August 2026.
A systemic single‐cell and spatially‐resolved transcriptomics and TCR sequencing analysis across the aging thymus dissects the molecular underpinnings of T cell subset dynamics. The study highlights the shifting proportions and transcriptomic profiles of T cell subsets during aging.
Jialing Fang, Jun Lei, Peng Chen, Zaiqiao Sun, Boxiao He, Yankang Wu, Chonil Paek, Ning Wu, Yafei Huang, ZhaoKui Dan, Hui Zhang, Zijing Xu, Pengcheng Wei, Yongshun Chen, Lei Yin   +14 more
wiley   +1 more source

IMGT®, biocuration of IG and TR in IMGT/LIGM-DB and IMGT/GENE-DB

, 2016
IMGT®, the international ImMunoGeneTics information system, http://www.imgt.org , is the global reference in immunogenetics and immunoinformatics. By managing the extreme diversity and complexity of the antigen receptors of the adaptive immune response, the immunoglobulins (IG) or antibodies and ...
Folch, Géraldine, Jabado-Michaloud, Joumana, Peralta, Marine, Arrivet, Mélanie, Imène Chentli, Cambon, Mélissa, Bento, Pascal, Souphatta Sasorith, Paysan-Lafosse, Typhaine, Duroux, Patrice, Giudicelli, Véronique, Kossida, Sofia, Marie-Paule Lefranc   +12 more
openaire   +1 more source

TR Locus Annotation and Characteristics of Rhinolophus ferrumequinum

Frontiers in Immunology, 2021
T-cell antigen receptors (TRs) in vertebrates can be divided into αβ or γδ, encoded by TRA/D, TRG, or TRB loci. TRs play a central role in mammal cellular immunity, which occurs by rearrangement of V, D, J, and C genes in the loci.
Hao Zhou, Long Ma, Longyu Liu, Xinsheng Yao   +3 more
doaj   +1 more source

Development and analytical validation of a targeted short‐read next generation sequencing‐based pharmacogenetic panel for comprehensive variant detection

British Journal of Pharmacology, Volume 183, Issue 16, Page 4735-4760, August 2026.
Abstract Background and Purpose Genomic profiling of patients for genetic variants that modify the effect of specific medications has many benefits, including the possibility of avoiding toxicities and ensuring an adequate effect of the medication. Our intention was to develop a comprehensive, high‐quality pharmacogenetic test panel for clinical use ...
Anna Gréen, Nils Johan Fredriksson, Michael Andresen, Jon Jonasson, Malin Lindqvist Appell, Henrik Gréen   +5 more
wiley   +1 more source

Genetic Diversity and Haplotype Architecture of Non‐Classical HLA Class I Genes in the Japanese Population

HLA, Volume 108, Issue 2, August 2026.
ABSTRACT The non‐classical Class I genes (HLA‐E, HLA‐F and HLA‐G) show limited protein‐level diversity; however, full‐length analyses that include regulatory and noncoding regions have not been sufficiently performed in East Asian populations. We designed new primers for long‐range PCR and conducted PacBio SMRT sequencing to generate full‐length gene ...
Ikue Ito‐Naito, Seik‐Soon Khor, Tetsuya Sato, Shunichi Wakabayashi, Daisuke Kinoshita, Naoya Kubo, Yosuke Omae, Katsushi Tokunaga, Hiroshi Hayashi   +8 more
wiley   +1 more source

IMGT/LIGM-DB, the IMGT(R) comprehensive database of immunoglobulin and T cell receptor nucleotide sequences [PDF]

Nucleic Acids Research, 2006
IMGT/LIGM-DB is the IMGT comprehensive database of immunoglobulin (IG) and T cell receptor (TR) nucleotide sequences from human and other vertebrate species. It was created in 1989 by LIGM, Montpellier, France and is the oldest and the largest database of IMGT.
Giudicelli, Véronique, Duroux, Patrice, Ginestoux, Chantal, Folch, Géraldine, Jabado-Michaloud, Joumana, Chaume, Denys, Lefranc, Marie-Paule   +6 more
openaire   +2 more sources