Results 71 to 80 of about 8,108 (168)
HLA, Volume 108, Issue 1, July 2026.ABSTRACT Non‐classical HLA Class I genes (HLA‐E, ‐F, ‐G, ‐H) and MHC‐related genes (MICA, MICB) regulate NK cell function and immune tolerance, yet their allelic diversity remains underexplored. Using capture‐enriched full‐gene sequencing of 943 healthy US transplant donors, we identified 26 novel alleles across HLA‐E (2), HLA‐F (6), HLA‐G (4), HLA‐H ...
Itta Krishna Chaaithanya +5 more
wiley +1 more source
A Streamlined Approach to Antibody Novel Germline Allele Prediction and Validation
Frontiers in Immunology, 2017 Advancements in high-throughput sequencing and molecular identifier-based error correction have opened the door to antibody repertoire sequencing with single mutation precision, increasing both the breadth and depth of immune response characterization ...
Ben S. Wendel +5 more
doaj +1 more source
Advanced Science, Volume 13, Issue 35, 24 June 2026.CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu +13 more
wiley +1 more source
Cancer Medicine, Volume 15, Issue 6, June 2026.ABSTRACT Adrenocortical carcinoma (ACC) is a rare and aggressive malignant neoplasm with limited therapeutic options and an often poor prognosis. A deeper understanding of its interaction with the immune system is essential for the advancement of personalized treatment strategies, particularly in light of the tumor heterogeneity of hormone production ...
Jean Silva de Souza Resende +6 more
wiley +1 more source
下一代测序鉴定新等位基因HLA-DQB1*04:74和HLA-DRB1*07:01:23序列及家系调查
Zhongguo shiyan zhenduanxue, 2021 人类对主要组织相容性复合物(MHC)的研究起源于同种异体组织器官移植和移植物的急性排斥反应。人类的MHC称为白细胞抗原(HLA)系统。HLA主要的遗传特征是共显性、多基因性和极度丰富的多态性。1958年第一个HLA抗原被检出,经过数十年的发展,相关工作者一直努力应对HLA不断扩大的等位基因数量。截至2020年4月更新的国际免疫遗传IMGT/HLA数据库3.40.0版(http//:www.ebi.ac.uk/imgt/hla/stats.html)显示,共计发现HLA-A座位等位基因6082种,
武君华 +7 more
doaj
Clinical &Translational Immunology, Volume 15, Issue 6, 2026.Single‐cell and paired V(D)J profiling show that paediatric adenoid hypertrophy features expanded proliferative germinal‐centre B cells with impaired maturation. Abstract Objectives To characterise the immune cellular landscape and paired B‐cell and T‐cell receptor repertoires of hypertrophic adenoids in children with obstructive sleep apnoea.
Chao Wang +6 more
wiley +1 more source
Frontiers in ImmunologyThrough the analysis of immunoglobulin genes at the IGH, IGK, and IGL loci from four Gorilla gorilla gorilla genome assemblies, IMGT® provides an in-depth overview of these loci and their individual variations in a species closely related to humans.
Chahrazed Debbagh +5 more
doaj +1 more source
HemaSphere, Volume 10, Issue 6, June 2026.Abstract IGLV3‐21R110 is a point mutation enabling autonomous B‐cell receptor (BCR) signaling in chronic lymphocytic leukemia (CLL). It has been associated with shorter time to first treatment and overall survival, but its effects have not been evaluated in phase 3 clinical trials or in patients treated with Bruton tyrosine kinase inhibitors.
Deyan Y. Yosifov +24 more
wiley +1 more source
Frontiers in Immunology, 2017 Phage-display selection of immunoglobulin (IG) or antibody single chain Fragment variable (scFv) from combinatorial libraries is widely used for identifying new antibodies for novel targets.
Audrey Hemadou +15 more
doaj +1 more source
Frontiers in Immunology, 2012 Sequence analysis of immunoglobulin (Ig) heavy and light chain transcripts can refine categorization of B cell subpopulations and can shed light on the selective forces that act during immune responses or immune dysregulation, such as autoimmunity ...
Tobias eRogosch +6 more
doaj +1 more source