Results 81 to 90 of about 8,734 (193)

Humanized Antibodies Targeting Ectodomains of IL‐6R and GP130 Suppress IL‐6/STAT3 Signalling and Tumour Growth in Breast Cancer Models

Journal of Cellular and Molecular Medicine, Volume 30, Issue 12, June 2026.
ABSTRACT Interleukin‐6 (IL‐6) signalling is a key driver of breast cancer progression, activating pro‐survival, pro‐inflammatory and metastatic programs through its receptors, IL‐6R and GP130. Elevated IL‐6 levels correlate with poor prognosis in breast cancer patients and persistent IL‐6/STAT3 activation promotes tumour proliferation, metastasis ...
Satyajit Dey Pereira, Guruprasad Baipadithaya, Keshava Prasad, Ritam Naha, Lavanya Prakash Acharya, Ganesh Prasad Uppenda Gopalakishna, Ramyaa Periasamy, Arun Chandrashekar, Shama Bhat, Manjunath B. Joshi, Kapaettu Satyamoorthy   +10 more
wiley   +1 more source

IMGT/3Dstructure-DB and IMGT/StructuralQuery, a database and a tool for immunoglobulin, T cell receptor and MHC structural data

, 2004
IMGT/3Dstructure-DB and IMGT/Structural-Query are a novel 3D structure database and a new tool for immunological proteins. They are part of IMGT, the international ImMunoGenetics information system®, a high-quality integrated knowledge resource ...
Kaas, Q., Ruiz, M., LeFranc, M-P
core   +1 more source

A Streamlined Approach to Antibody Novel Germline Allele Prediction and Validation

Frontiers in Immunology, 2017
Advancements in high-throughput sequencing and molecular identifier-based error correction have opened the door to antibody repertoire sequencing with single mutation precision, increasing both the breadth and depth of immune response characterization ...
Ben S. Wendel, Chenfeng He, Peter D. Crompton, Susan K. Pierce, Ning Jiang, Ning Jiang   +5 more
doaj   +1 more source

High‐Resolution NGS HLA Typing Identifies Specific Class II–Dominant Risk Haplotypes and HLA LD Structure in Acute Lymphoblastic Leukaemia Among Ethnic Kazakhs

HLA, Volume 107, Issue 6, June 2026.
ABSTRACT Acute lymphoblastic leukaemia (ALL) results from the uncontrolled growth of lymphoid progenitors, yet the immunogenetic factors behind this remain poorly understood. A connection between specific HLA alleles, multi‐locus haplotypes and ALL predisposition was suggested, with an ethnic component to this association.
Zhandos Burkitbayev, Aida Turganbekova, Zhulduz Zhanzakova, Dana Baimukasheva, Zhazira Saduakas, Didara Khamitova, Saniya Abdrakhmanova, Zhaksylyk Masalimov, Wassim Y. Almawi   +8 more
wiley   +1 more source

IMGT/DomainGapAlign: IMGT Standardized Analysis of Amino Acid Sequences of Variable, Constant, and Groove Domains (IG, TR, MH, IgSF, MhSF)

, 2011
INTRODUCTIONIMGT/DomainGapAlign is the IMGT online tool for the analysis of amino acid (AA) sequences and two-dimensional (2D) structures of domains. The use of this tool is described here.
Marie-Paule Lefranc, Ehrenmann, François, Lefranc, Mp, François Ehrenmann   +3 more
core   +1 more source

下一代测序鉴定新等位基因HLA-DQB1*04:74和HLA-DRB1*07:01:23序列及家系调查

Zhongguo shiyan zhenduanxue, 2021
人类对主要组织相容性复合物(MHC)的研究起源于同种异体组织器官移植和移植物的急性排斥反应。人类的MHC称为白细胞抗原(HLA)系统。HLA主要的遗传特征是共显性、多基因性和极度丰富的多态性。1958年第一个HLA抗原被检出,经过数十年的发展,相关工作者一直努力应对HLA不断扩大的等位基因数量。截至2020年4月更新的国际免疫遗传IMGT/HLA数据库3.40.0版(http//:www.ebi.ac.uk/imgt/hla/stats.html)显示,共计发现HLA-A座位等位基因6082种,
武君华, 王满妮, 王天菊, 王小芳, 尚利侠, 陈乐, 房婕, 齐珺   +7 more
doaj  

Unfavourable H‐CDR3 Loops in preB Cells Lead to Highly Expanded Plasma Cell Clones

European Journal of Immunology, Volume 56, Issue 5, May 2026.
In the absence of a pre‐BCR, a subset of mature B cells that expresses IgH chains with very short, hydrophobic and positively charged H‐CDR3 loops is generated. This results in massive clonal expansion and the development of autoreactive plasma cells exhibiting these characteristics.
Alaitz Aranburu, Erik Engström, Erik Demitz‐Helin, Julia M. Scheffler, Alessandro Camponeschi, Timothy Sundell, Zhong Ni, Inga‐Lill Mårtensson   +7 more
wiley   +1 more source

IMGT-Choreography for immunogenetics and immunoinformatics.

, 2005
International audienceIMGT, the international ImMunoGeneTics information system (http://imgt.cines.fr), was created in 1989 at Montpellier, France. IMGT is a high quality integrated knowledge resource specialized in immunoglobulins (IG), T cell receptors
Combres, Kora, Chaume, Denys, Kaas, Quentin, Duprat, Elodie, Lefranc, Gérard, Ginestoux, Chantal, Chastellan, Patrick, Giudicelli, Véronique, Lefranc, Marie-Paule, Clément, Olivier, Coelho, Isabelle   +10 more
core   +1 more source

Deciphering Gorilla gorilla gorilla immunoglobulin loci in multiple genome assemblies and enrichment of IMGT resources

Frontiers in Immunology
Through the analysis of immunoglobulin genes at the IGH, IGK, and IGL loci from four Gorilla gorilla gorilla genome assemblies, IMGT® provides an in-depth overview of these loci and their individual variations in a species closely related to humans.
Chahrazed Debbagh, Géraldine Folch, Joumana Jabado-Michaloud, Véronique Giudicelli, Sofia Kossida, Sofia Kossida   +5 more
doaj   +1 more source

Stable β2‐Microglobulin–HLA Class I Association Reshapes the Antigenic Landscape and TCR Recognition of Cancer‐Associated Epitopes

European Journal of Immunology, Volume 56, Issue 5, May 2026.
We investigated differences in peptide repertoire when β2‐microglobulin is fused to the HLA‐I heavy chain. We observed: (1) that immunopeptidomes changed in this condition, (2) an overall increased median IC50 of the entire peptide repertoire, and (3) a reduced presentation of cancer‐specific epitopes with a strong predicted binding affinity for HLA‐I.
Ana Barajas Molina, Yehor Horokhovskyi, Nicole Acuti, Yee Kien Chong, Meghna Phanichkrivalkosil, Sophie Siddons, Hassnae Afrache, Megan Maloney, Wai Tuck Soh, Tom Hofland, Callum Hall, Henning Urlaub, George Kassiotis, Juliane Liepe, Michele Mishto   +14 more
wiley   +1 more source