Results 91 to 100 of about 9,211 (171)

Use of IMGT® Databases and Tools for Antibody Engineering and Humanization

, 2018
International audienceIMGT®, the international ImMunoGeneTics information system® ( http://www.imgt.org ), was created in 1989 by Marie-Paule Lefranc (Université de Montpellier and CNRS) to manage the huge diversity of the antigen receptors ...
Marie-Paule Lefranc, Duroux, Patrice, Ehrenmann, François, Patrice Duroux, François Ehrenmann, Giudicelli, Véronique, Véronique Giudicelli, Lefranc, Marie-Paule, Sofia Kossida, Kossida, Sofia   +9 more
core   +1 more source

Invariant γδTCR natural killer-like effector T cells in the naked mole-rat

Nature Communications
The naked mole-rat (Heterocephalus glaber) is a long-lived rodent species showing resistance to the development of cancer. Although naked mole-rats have been reported to lack natural killer (NK) cells, γδ T cell-based immunity has been suggested in this ...
Guillem Sanchez Sanchez, Stephan Emmrich, Maria Georga, Ariadni Papadaki, Sofia Kossida, Andrei Seluanov, Vera Gorbunova, David Vermijlen   +7 more
doaj   +1 more source

Ultrasound-Sensitive Liposomal Exatecan for Tumor-Specific Drug Release for Treatment of Pancreatic Cancer

Pharmaceutics
Background: Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal cancers, largely due to its dense stromal architecture and poor intratumoral drug penetration.
Dongyeon Kim, Hyungwon Moon, Sunyoung Han, Hak Jong Lee   +3 more
doaj   +1 more source

IMGT/HighV-QUEST: the IMGT® web portal for immunoglobulin (IG) or antibody and T cell receptor (TR) analysis from NGS high throughput and deep sequencing

, 2012
International audienceBackgroundThe number of antigen receptors, immunoglobulins (IG) or antibodies and T cell receptors (TR) of the adap-tive immune response in vertebrates with jaws is almost unlimited (2.1012per individual in humans).
Duroux, Patrice, Li, Shuo, Giudicelli, Véronique, Alamyar, E., Lefranc, Marie-Paule   +4 more
core   +2 more sources

Three-Dimensional Modeling of Camelus dromedarius T Cell Receptor Gamma (TRG)_Delta (TRD)/CD1D Complex Reveals Different Binding Interactions Depending on the TRD CDR3 Length

Antibodies
Background: In the adaptive immune response of the dromedary (Camelus dromedarius, Camdro), the T cell receptor (TR) repertoire of the gamma–delta (γδ) T cells is unusually diversified both by somatic hypermutation in rearranged TR gamma (TRG) and delta (
Salvatrice Ciccarese, Marie-Paule Lefranc, Giulia C. M. Perrone, Pietro D’Addabbo, Ciro Leonardo Pierri   +4 more
doaj   +1 more source

Advances in MICA genotyping: characterization of 406 novel alleles and their frequencies in multiple populations

Frontiers in Immunology
In 2020, we reported MICA allele frequencies from a cohort of over one million German individuals. This study identified MICA*008 (42%), MICA*002 (12%), and MICA*009 (9%) as the most common MICA alleles at protein resolution.
Viviane Albrecht, Christin Paech, Kathrin Putke, Gerhard Schöfl, Jürgen Sauter, Alexander H. Schmidt, Alexander H. Schmidt, Vinzenz Lange, Anja Klussmeier   +8 more
doaj   +1 more source

IPD - the Immuno Polymorphism Database [PDF]

, 2005
The Immuno Polymorphism Database (IPD) (http://www.ebi.ac.uk/ipd/) is a set of specialist databases related to the study of polymorphic genes in the immune system.
Marsh, S.G.E., Robinson, J., Waller, M.J., Stoehr, P.   +3 more
core  

IMGT standardization for molecular characterization of the T-cell receptor/peptide/MHC complexes

, 2008
One of the key elements in the adaptive immune response is the presentation of peptides by the major histocompatibility complex (MHC) to the T-cell receptors (TR) at the surface of T cells.
Kaas, Quentin, Duprat, Elodie, Tourneur, Guillaume, Lefranc, Marie-Paule   +3 more
core   +1 more source

From benchmarking alignment of genome assemblies to IMGT annotation: the paradigm of the bovine Bos taurus T cell receptor (TRG) locus

BMC Genomics
T cell receptors (TR) are essential components of the adaptive immune system, typically classified into αβ and γδ types. In humans and mice, αβ T cells predominate, with γδ T cells comprising only a small percentage of the total T cell population.
Hao Zhou, Chimari Jiko, Christoph Gerle, Marie-Paule Lefranc, Kazutaka Katoh, Daron M. Standley   +5 more
doaj   +1 more source

IMGT® at scale: FAIR, dynamic, and automated tools for immune locus analysis

International audienceIMGT ® , the international ImMunoGeneTics information system ® , has advanced its comprehensive platform for the analysis of immunoglobulin (IG) and T-cell receptor (TR) genes through the de v elopment of ne w automated and scalable
Eidi, Milad, Croze, Myriam, Jabado-Michaloud, Joumana, Atr Ice Duroux, P, Debbagh, Chahrazed, Duroux, Patrice, Kushwaha, Anjana, Kushw Aha, Anjana, Manso, Taciana, Croz, Myriam, Zeitoun, Guilhem, Papadaki, Ariadni, Abado-Mic Haloud, Joumana, J, Kan Samadov, Tur, Samadova, Turkan, Folch, G\ue9raldine, Giudicelli, V\ue9ronique, Abdollahi, Nika, Sideri, Ifigeneia, Grand, Fran\ue7ois, Sider, Ifigeneia, Batool, Shamsa, Giudicelli, Véronique, Vaillant, Axel, Sanou, Gaoussou, Georga, Maria, El Vaillant, Ax, Kossida, Sofia   +27 more
core   +1 more source