Results 1 to 10 of about 524 (113)
Frontiers in Genetics, 2012 Immunogenetics is the science that studies the genetics of the immune system and immune responses. Owing to the complexity and diversity of the immune repertoire, immunogenetics represents one of the greatest challenges for data interpretation: a large biological expertise, a considerable effort of standardization and the elaboration of an efficient ...
Véronique Giudicelli +2 more
exaly +6 more sources
Immunoglobulins: 25 Years of Immunoinformatics and IMGT-ONTOLOGY [PDF]
Biomolecules, 2014 IMGT®, the international ImMunoGeneTics information system® (CNRS and Montpellier University) is the global reference in immunogenetics and immunoinformatics. By its creation in 1989, IMGT® marked the advent of immunoinformatics, which emerged at the interface between immunogenetics and bioinformatics.
Marie-Paule Lefranc +1 more
exaly +5 more sources
Ontology for immunogenetics: the IMGT-ONTOLOGY [PDF]
Bioinformatics, 1999 Abstract Motivation: IMGT, the international ImMunoGene- Tics database (http://imgt.cines.fr:8104), created by M.-P. Lefranc, is an integrated database specializing in antigen receptors (immunoglobulins and T-cell receptors) and major histocompatibility complex (MHC) of all vertebrate species.
Véronique Giudicelli +2 more
exaly +4 more sources
A novel paradigm for cell and molecule interaction ontology: from the CMM model to IMGT-ONTOLOGY [PDF]
Immunome Research, 2010 Biology is moving fast toward the virtuous circle of other disciplines: from data to quantitative modeling and back to data. Models are usually developed by mathematicians, physicists, and computer scientists to translate qualitative or semi-quantitative biological knowledge into a quantitative approach.
PAPPALARDO, FRANCESCO +3 more
openaire +5 more sources
IMGT-Kaleidoscope, the formal IMGT-ONTOLOGY paradigm [PDF]
Biochimie, 2008 IMGT, the international ImMunoGeneTics information system (http://imgt.cines.fr), is the reference in immunogenetics and immunoinformatics. IMGT standardizes and manages the complex immunogenetic data which include the immunoglobulins (IG) or antibodies, the T cell receptors (TR), the major histocompatibility complex (MHC) and the related proteins of ...
Patrice Duroux +2 more
exaly +6 more sources
mAbs, 2011 An ontology is a formal representation of a knowledge domain. IMGT-ONTOLOGY was created to manage the complexity of immunogenetics knowledge and was the first ontology in the domain.1 IMGT-ONTOLOGY...
Lefranc MP.
openaire +4 more sources
From IMGT-ONTOLOGY to IMGT/LIGMotif: the IMGT® standardized approach for immunoglobulin and T cell receptor gene identification and description in large genomic sequences [PDF]
BMC Bioinformatics, 2010 Abstract Background The antigen receptors, immunoglobulins (IG) and T cell receptors (TR), are specific molecular components of the adaptive immune response of vertebrates. Their genes are organized in the genome in several loci (7 in humans) that comprise different gene types: variable (V), diversity (D), joining (J)
Jérôme Lane +2 more
openaire +5 more sources
Using IMGT unique numbering for IG allotypes and Fc‐engineered variants of effector properties and half‐life of therapeutic antibodies [PDF]
Immunological Reviews, Volume 328, Issue 1, Page 473-506, November 2024.Summary Therapeutic monoclonal antibodies (mAb) are usually of the IgG1, IgG2, and IgG4 classes, and their heavy chains may be modified by amino acid (aa) changes involved in antibody‐dependent cellular cytotoxicity (ADCC), antibody‐dependent cellular phagocytosis (ADCP), complement‐dependent cytotoxicity (CDC), and/or half‐life.
Marie‐Paule Lefranc, Gérard Lefranc
wiley +2 more sources
A Scalable Framework for Comprehensive Typing of Polymorphic Immune Genes from Long‐Read Data [PDF]
Advanced Science, Volume 13, Issue 22, 17 April 2026.SpecImmune introduces a unified computational framework optimized for long‐read sequencing to resolve over 400 highly polymorphic immune genes. This scalable approach achieves high‐resolution typing, enabling the discovery of cross‐family co‐evolutionary networks and population‐specific diversity.
Shuai Wang +5 more
wiley +2 more sources
Immunogenetic sequence annotation based on IMGT-ONTOLOGY
Nature Precedings, 2009 AbstractIMGT/LIGM-DB^1^ is the first and the largest IMGT^®^ database^2^ in which are managed, analysed and annotated more than 136,000 immunoglobulin (IG) and T cell receptor (TR) nucleotide sequences from human and 235 other vertebrate species (April 2009).
Véronique Giudicelli +2 more
exaly +3 more sources