Immunoglobulins: 25 Years of Immunoinformatics and IMGT-ONTOLOGY [PDF]
Biomolecules, 2014 IMGT®, the international ImMunoGeneTics information system® (CNRS and Montpellier University) is the global reference in immunogenetics and immunoinformatics.
Marie-Paule Lefranc
exaly +4 more sources
Frontiers in Genetics, 2012 Immunogenetics is the science that studies the genetics of the immune system and immune responses. Owing to the complexity and diversity of the immune repertoire, immunogenetics represents one of the greatest challenges for data interpretation: a large ...
Véronique eGiudicelli +1 more
doaj +2 more sources
IMGT-NC Engineered Variants of INN Therapeutic IG or Antibodies and Related IgSF Proteins (TR, FPIA and CPCA): Bridging Sequences, Structures and Functions for AI [PDF]
BiomoleculesIMGT®, the international information system® (IMGT), was created in 1989 by Marie-Paule Lefranc (Université de Montpellier and CNRS) in Montpellier, France, to deal with and to manage the huge diversity of immunoglobulins (IG) or antibodies and T-cell ...
Marie-Paule Lefranc
doaj +2 more sources
From IMGT-ONTOLOGY to IMGT/LIGMotif: the IMGT® standardized approach for immunoglobulin and T cell receptor gene identification and description in large genomic sequences [PDF]
BMC Bioinformatics, 2010 Background The antigen receptors, immunoglobulins (IG) and T cell receptors (TR), are specific molecular components of the adaptive immune response of vertebrates.
Lefranc Marie-Paule +2 more
doaj +2 more sources
IMGT® Nomenclature of Immunoglobulins (IG) or Antibodies and T Cell Receptors (TR): A Common Language for Immunoinformatics and Artificial Intelligence (AI) [PDF]
AntibodiesThe immunoglobulins (IG) or antibodies and the T cell receptors (TR) are the antigen receptors of the adaptive immune responses (AIR) of jawed vertebrates (Gnathostomata).
Marie-Paule Lefranc, Gérard Lefranc
doaj +2 more sources
IMGT®Homo sapiens IG and TR Loci, Gene Order, CNV and Haplotypes: New Concepts as a Paradigm for Jawed Vertebrates Genome Assemblies [PDF]
Biomolecules, 2022 IMGT®, the international ImMunoGeneTics information system®, created in 1989, by Marie-Paule Lefranc (Université de Montpellier and CNRS), marked the advent of immunoinformatics, a new science which emerged at the interface between immunogenetics and ...
Marie-Paule Lefranc, Gérard Lefranc
doaj +2 more sources
Using IMGT unique numbering for IG allotypes and Fc-engineered variants of effector properties and half-life of therapeutic antibodies. [PDF]
Immunol RevSummary Therapeutic monoclonal antibodies (mAb) are usually of the IgG1, IgG2, and IgG4 classes, and their heavy chains may be modified by amino acid (aa) changes involved in antibody‐dependent cellular cytotoxicity (ADCC), antibody‐dependent cellular phagocytosis (ADCP), complement‐dependent cytotoxicity (CDC), and/or half‐life.
Lefranc MP, Lefranc G.
europepmc +2 more sources
A Scalable Framework for Comprehensive Typing of Polymorphic Immune Genes from Long-Read Data. [PDF]
Adv Sci (Weinh)SpecImmune introduces a unified computational framework optimized for long‐read sequencing to resolve over 400 highly polymorphic immune genes. This scalable approach achieves high‐resolution typing, enabling the discovery of cross‐family co‐evolutionary networks and population‐specific diversity.
Wang S +5 more
europepmc +2 more sources
Newly developed humanized anti-CKAP4 antibody suppresses pancreatic cancer growth by inhibiting DKK1-CKAP4 signaling. [PDF]
Cancer SciOncogenic DKK1–CKAP4 signaling axis is activated in pancreatic cancer and associated with a poor prognosis. In this study, we have for the first time developed a humanized anti‐CKAP4 antibody based on the structure of a previously developed mouse anti‐CKAP4 monoclonal antibody 3F11‐2B10.
Sada R +4 more
europepmc +2 more sources
IMGT/HighV-QUEST Statistical Significance of IMGT Clonotype (AA) Diversity per Gene for Standardized Comparisons of Next Generation Sequencing Immunoprofiles of Immunoglobulins and T Cell Receptors. [PDF]
PLoS ONE, 2015 The adaptive immune responses of humans and of other jawed vertebrate species (gnasthostomata) are characterized by the B and T cells and their specific antigen receptors, the immunoglobulins (IG) or antibodies and the T cell receptors (TR) (up to 2.1012
Safa Aouinti +4 more
doaj +1 more source