Results 21 to 30 of about 235,488 (146)

Prostate cancer disease recurrence after radical prostatectomy is associated with HLA type and local cytomegalovirus immunity

Molecular Oncology, Volume 16, Issue 19, Page 3452-3464, October 2022., 2022
In this study, we find that variants of genes that are essential for the immune system (HLA‐A*02:01 and HLA‐A*11) are associated with prostate cancer progression after radical prostatectomy. Local detection of immunity to cytomegalovirus, but not EBV or Influenza A, was associated with particularly low disease recurrence‐free survival, suggesting that ...
Johanna Classon, Margherita Zamboni, Camilla Engblom, Kanar Alkass, Giulia Mantovani, Christian Pou, Dieudonné Nkulikiyimfura, Petter Brodin, Henrik Druid, Jeff Mold, Jonas Frisén   +10 more
wiley   +1 more source

IMGT^® and 30 Years of Immunoinformatics Insight in Antibody V and C Domain Structure and Function

Antibodies, 2019
At the 10th Human Genome Mapping (HGM10) Workshop, in New Haven, for the first time, immunoglobulin (IG) or antibody and T cell receptor (TR) variable (V), diversity (D), joining (J), and constant (C) genes were officially recognized as ‘genes ...
Marie-Paule Lefranc, Gérard Lefranc
doaj   +1 more source

Allogeneic CD20‐targeted γδ T cells exhibit innate and adaptive antitumor activities in preclinical B‐cell lymphoma models

Clinical &Translational Immunology, Volume 11, Issue 2, 2022., 2022
The findings of our study demonstrate preclinical proof of concept for a CD20 CAR+ Vδ1 γδ T‐cell product, manufactured at clinical scale, in the treatment of CD20+ B‐cell malignancies. Complemented by innate and adaptive antitumor immunity, CD20 CAR+ Vδ1 γδ T cells have a unique advantage as an allogeneic CAR T‐cell product platform and, as a ...
Kevin P Nishimoto, Taylor Barca, Aruna Azameera, Amani Makkouk, Jason M Romero, Lu Bai, Mary M Brodey, Jackie Kennedy‐Wilde, Hui Shao, Stephanie Papaioannou, Amy Doan, Cynthia Masri, Ngoc T Hoang, Hayden Tessman, Vidhya Dhevi Ramanathan, Ana Giner‐Rubio, Frank Delfino, Kriti Sharma, Kevin Bray, Matthew Hoopes, Daulet Satpayev, Ranjita Sengupta, Marissa Herrman, Stewart E Abbot, Blake T Aftab, Zili An, Swapna Panuganti, Sandra M Hayes   +27 more
wiley   +1 more source

Immunoglobulin (IG) and T cell receptor (TR) genes: IMGT® and the birth and rise of immunoinformatics

Frontiers in Immunology, 2014
IMGT®, the international ImMunoGeneTics information system®, http://www.imgt.org (CNRS and Université Montpellier 2) is the global reference in immunogenetics and immunoinformatics.
Marie-Paule eLefranc
doaj   +1 more source

Recovering probabilities for nucleotide trimming processes for T cell receptor TRA and TRG V-J junctions analyzed with IMGT tools

BMC Bioinformatics, 2008
Background Nucleotides are trimmed from the ends of variable (V), diversity (D) and joining (J) genes during immunoglobulin (IG) and T cell receptor (TR) rearrangements in B cells and T cells of the immune system. This trimming is followed by addition of
Lefranc Marie-Paule, Bleakley Kevin, Biau Gérard   +2 more
doaj   +1 more source

IMGT/HighV QUEST paradigm for T cell receptor IMGT clonotype diversity and next generation repertoire immunoprofiling [PDF]

, 2013
T cell repertoire diversity and clonotype follow-up in vaccination, cancer, infectious and immune diseases represent a major challenge owing to the enormous complexity of the data generated.
Burrows, Scott R., Gowans, E., Corbin, Vincent D.A., Freeman, J Douglas, Papenfuss, Anthony, Scheerlinck, J. P., Burrows, S, Scheerlinck, J., Papenfuss, A., Papenfuss, A. T., Corbin, Vincent D. A., Alamyar, Eltaf, Burrows, SR, Freeman, J. Douglas, Corbin, Vincent, Duroux, P., Gowans, EJ, Papenfuss, Anthony, T., Miles, J., Freeman, J., Giudicelli, V., Burrows, Scott, Gowans, E. J., Gowans, E, Loveland, B, Giudicelli, Veronique, Papenfuss, AT, Miles, J. J., Corbin, Vincent, D. A., Freeman, JD, Li, S., Scheerlinck, Jean-Paul, Lefranc, M. P., Duroux, P, Cameron, Paul, U., Duroux, Patrice, Miles, JJ, Papenfuss, Anthony T., Lefranc, MP, Frohman, Michael A., Miles, John J., Cameron, PU, Plebanski, Magdalena, Scheerlinck, Jean-Pierre, Burrows, S. R., Gowans, Eric, Loveland, B., Alamyar, E., Lefranc, Marie-Paule, Corbin, VDA, Gowans, Eric J., Giudicelli, V, Scheerlinck, JP, Frohman, M. A., Lefranc, M., Burrows, Scott, R., Li, Shuo, Plebanski, M., Cameron, Paul U., Corbin, V. D., Loveland, Bruce, Freeman, John, Cameron, Paul, Frohman, MA, Corbin, V., Frohman, Michael, Plebanski, M, Burrows, S., Cameron, P., Cameron, P. U., Frohman, M., Miles, John, Freeman, J. D., Li, S, Alamyar, E   +74 more
core   +1 more source

An Ontology for Submarine Feature Representation on Charts [PDF]

, 2013
A landform is a subjective individuation of a part of a terrain. Landform recognition is a difficult task because its definition usually relies on a qualitative and fuzzy description.
YAN, Jingya, GUILBERT, Eric, Jingya Yan, Eric Guilbert, Eric Saux, SAUX, Eric   +5 more
core   +1 more source

Proposed method to build an ontology based on Folksonomy [PDF]

, 2012
Ontology design builds upon taxonomy. The problem is that taxonomy depends on controlled vocabulary which has many drawbacks, particularly in the environments that depend on social networking, which are shaped and formed generally from contributions of ...
Binzabiah, Reyad, Wade, Steve
core   +3 more sources

Single Cell and Spatially Resolved Transcriptome and Immune Repertoire of Mouse Thymus During Aging Reveal Immunological Heterogeneity and Direction of Thymic Selection Pressure

Aging Cell, Volume 25, Issue 8, August 2026.
A systemic single‐cell and spatially‐resolved transcriptomics and TCR sequencing analysis across the aging thymus dissects the molecular underpinnings of T cell subset dynamics. The study highlights the shifting proportions and transcriptomic profiles of T cell subsets during aging.
Jialing Fang, Jun Lei, Peng Chen, Zaiqiao Sun, Boxiao He, Yankang Wu, Chonil Paek, Ning Wu, Yafei Huang, ZhaoKui Dan, Hui Zhang, Zijing Xu, Pengcheng Wei, Yongshun Chen, Lei Yin   +14 more
wiley   +1 more source

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, Volume 13, Issue 35, 24 June 2026.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source