Results 11 to 20 of about 524 (113)

Newly developed humanized anti‐CKAP4 antibody suppresses pancreatic cancer growth by inhibiting DKK1‐CKAP4 signaling [PDF]

Cancer Science, Volume 115, Issue 10, Page 3358-3369, October 2024.
Oncogenic DKK1–CKAP4 signaling axis is activated in pancreatic cancer and associated with a poor prognosis. In this study, we have for the first time developed a humanized anti‐CKAP4 antibody based on the structure of a previously developed mouse anti‐CKAP4 monoclonal antibody 3F11‐2B10.
Ryota Sada, Hideki Yamamoto, Shinji Matsumoto, Akikazu Harada, Akira Kikuchi   +4 more
wiley   +2 more sources

IMGT-ONTOLOGY for immunogenetics and immunoinformatics.

In silico biology, 2003
IMGT, the international ImMunoGeneTics information system(R) (http://imgt.cines.fr), is a high quality integrated knowledge resource specializing in immunoglobulins (IG), T cell receptors (TR), major histocompatibility complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrates, created in 1989, by the Laboratoire d ...
Lefranc, Marie-Paule, Giudicelli, Véronique, Ginestoux, Chantal, Bosc, Nathalie, Folch, Géraldine, Guiraudou, Delphine, Jabado-Michaloud, Joumana, Magris, Séverine, Scaviner, Dominique, Thouvenin, Valérie, Combres, Kora, Girod, David, Jeanjean, Stéphanie, Protat, Céline, Yousfi-Monod, Mehdi, Duprat, Elodie, Kaas, Quentin, Pommié, Christelle, Chaume, Denys, Lefranc, Gérard   +19 more
openaire   +8 more sources

High activation levels maintained in receptor‐binding domain–specific memory B cells in people with severe coronavirus disease 2019

Immunology &Cell Biology, Volume 101, Issue 2, Page 142-155, February 2023., 2023
We performed an in‐depth single‐cell gene expression analysis of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) receptor‐binding domain–specific memory B cells in three patients after severe coronavirus disease 2019 (COVID‐19) and four patients after mild/moderate COVID‐19.
Money Gupta, Harikrishnan Balachandran, Raymond H Y Louie, Hui Li, David Agapiou, Elizabeth Keoshkerian, Daniel Christ, William Rawlinson, Michael M Mina, Jeffrey J Post, Bernard Hudson, Nicky Gilroy, Pamela Konecny, Adam W Bartlett, Sarah C Sasson, Golo Ahlenstiel, Dominic Dwyer, Andrew R Lloyd, Marianne Martinello, Fabio Luciani, Rowena A Bull, on behalf of the COSIN study group   +21 more
wiley   +1 more source

Prostate cancer disease recurrence after radical prostatectomy is associated with HLA type and local cytomegalovirus immunity

Molecular Oncology, Volume 16, Issue 19, Page 3452-3464, October 2022., 2022
In this study, we find that variants of genes that are essential for the immune system (HLA‐A*02:01 and HLA‐A*11) are associated with prostate cancer progression after radical prostatectomy. Local detection of immunity to cytomegalovirus, but not EBV or Influenza A, was associated with particularly low disease recurrence‐free survival, suggesting that ...
Johanna Classon, Margherita Zamboni, Camilla Engblom, Kanar Alkass, Giulia Mantovani, Christian Pou, Dieudonné Nkulikiyimfura, Petter Brodin, Henrik Druid, Jeff Mold, Jonas Frisén   +10 more
wiley   +1 more source

Allogeneic CD20‐targeted γδ T cells exhibit innate and adaptive antitumor activities in preclinical B‐cell lymphoma models

Clinical &Translational Immunology, Volume 11, Issue 2, 2022., 2022
The findings of our study demonstrate preclinical proof of concept for a CD20 CAR+ Vδ1 γδ T‐cell product, manufactured at clinical scale, in the treatment of CD20+ B‐cell malignancies. Complemented by innate and adaptive antitumor immunity, CD20 CAR+ Vδ1 γδ T cells have a unique advantage as an allogeneic CAR T‐cell product platform and, as a ...
Kevin P Nishimoto, Taylor Barca, Aruna Azameera, Amani Makkouk, Jason M Romero, Lu Bai, Mary M Brodey, Jackie Kennedy‐Wilde, Hui Shao, Stephanie Papaioannou, Amy Doan, Cynthia Masri, Ngoc T Hoang, Hayden Tessman, Vidhya Dhevi Ramanathan, Ana Giner‐Rubio, Frank Delfino, Kriti Sharma, Kevin Bray, Matthew Hoopes, Daulet Satpayev, Ranjita Sengupta, Marissa Herrman, Stewart E Abbot, Blake T Aftab, Zili An, Swapna Panuganti, Sandra M Hayes   +27 more
wiley   +1 more source

UEG Week 2023 Poster Presentations

, 2023
United European Gastroenterology Journal, Volume 11, Issue S8, Page 535-1498, October 2023.
wiley   +1 more source

Single‐Cell Dissection Reveals Immune Dysregulation After CD5 or CD7‐Directed Chimeric Antigen Receptor T‐Cell Therapy

Advanced Science, Volume 13, Issue 8, 9 February 2026.
Single‐cell RNA/TCR/BCR sequencing reveals that 5CAR therapy in T‐ALL induces T‐cell exhaustion, reduces EBV‐associated TCRs, lowers TCR/BCR diversity, and increases NK/DC/monocyte activation and function. In contrast, 7CAR therapy reduces multiple pathogen‐associated TCRs, enhances NK cell activation and function, decreases monocyte activation, and ...
Yuechen Luo, Haixiao Zhang, Kaiting Tang, Yiming Wang, Huajiang Dong, Wei Qi, Lingling Shan, Yue Tan, Liping Zhao, Jun Shi, Erlie Jiang, Jing Pan, Xiaoming Feng   +12 more
wiley   +1 more source

From IMGT-ONTOLOGY to IMGT/HighVQUEST for NGS Immunoglobulin (IG) and T cell Receptor (TR) Repertoires in Autoimmune and Infectious Diseases [PDF]

Autoimmune and Infectious Diseases: Open Access ( ISSN 2470-1025 ), 2015
The analysis of adaptive immune repertoires in autoimmune and infectious diseases represents a fascinating challenge because of the natural huge diversity of the antigen receptors that are the immunoglobulins or antibodies and T cell receptors, expressed by B cells and T cells, respectively.
Giudicelli, Véronique, Duroux, Patrice, Lavoie, Arthur, Aouinti, Safa, Lefranc, Marie-Paule, Kossida, Sofia   +5 more
openaire   +1 more source

Abstract Book for the 27th Congress of the European Hematology Association

, 2022
HemaSphere, Volume 6, Issue S3, Page 1-4130, June 2022.
wiley   +1 more source

EHA2021 Virtual Congress Abstract Book

, 2021
HemaSphere, Volume 5, Issue S2, June 2021.
wiley   +1 more source