Results 61 to 70 of about 9,211 (171)

IMGT/3Dstructure-DB and IMGT/DomainGapAlign: a database and a tool for immunoglobulins or antibodies, T-cell receptors, MHC, IgSF and MhcSF [PDF]

, 2009
IMGT/3Dstructure-DB is the three-dimensional (3D) structure database of IMGT. ®, the international ImMunoGenetics information system. ® that is acknowledged as the global reference in immunogenetics and immunoinformatics.
Ehrenmann, F., Ehrenmann, François, Kaas, Q., Lefranc, M.-P., Lefranc, Marie-Paule   +4 more
core   +1 more source

Somatic Hypermutations Enhance Neutralization Breadth of IGHV3‐53/3‐66 Public Antibodies Against SARS‐CoV‐2 Variants

Immunity, Inflammation and Disease, Volume 14, Issue 9, September 2026.
ABSTRACT Objective Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) continuously evolves to evade antibodies elicited by prior infection or vaccination. Most IGHV3‐53/3‐66 public antibodies potently neutralize the prototype strain, but show limited activity against recent variants.
Takeo Kuwata, Kyo Okazaki, Hiroshi Morioka, Yu Kaku, Mikiko Shimizu, Yoshimi Maruyama, Ahmed K. Hamdy, The Genotype to Phenotype Japan (G2P‐Japan) Consortium, Tateki Suzuki, Takao Hashiguchi, Kei Sato, Shuzo Matsushita   +11 more
wiley   +1 more source

From IMGT-ONTOLOGY IDENTIFICATION Axiom to IMGT Standardized Keywords: For Immunoglobulins (IG), T Cell Receptors (TR), and Conventional Genes

, 2011
INTRODUCTIONIMGT standardized keywords have been defined for the identification of immunoglobulins (IG) and T cell receptors (TR) and conventional genes.
Marie-Paule Lefranc, Lefranc, Mp
core   +1 more source

Multiomics Insights Into AL Amyloidosis

Medicine Bulletin, Volume 2, Issue 4, Page 434-458, September 2026.
ABSTRACT Light chain amyloidosis is a systemic or localized protein conformational disorder triggered by misfolded immunoglobulin light chains, leading to amyloid fibril deposition. The disease is characterized by multiorgan involvement and delayed diagnosis, contributing to poor prognosis and high mortality rates.
Zixuan Zhang, Ziru Huang, Haoxiang Tang, Xianrun Pan, Rong Wang, Dingding Zhang, Jian Huang   +6 more
wiley   +1 more source

Standardized Sequence and Structure Analysis of Antibody Using IMGT®

, 2010
International audienceStandardized sequence and structure analysis of antibody using IMGT®, the international ImMunoGeneTics information system® (http://www.imgt.org), allows to bridge, for the first time, the gap between antibody sequences and three ...
Marie-Paule Lefranc, Duroux, Patrice, Ehrenmann, François, Patrice Duroux, François Ehrenmann, Giudicelli, Véronique, Véronique Giudicelli, Lefranc, Marie-Paule   +7 more
core   +1 more source

IMGT-Collier-de-Perles_heavy_chain.zip

, 2021
Supplementary information: 2D antibody structure information (Collier-de-Perles representation) of coronavirus related neutralizing antibodies. (for heavy chain)
Puneet Rawat (11551201)
core   +1 more source

Optimization of antibody binding by adjusting thermodynamic stability during the maturation of antibody affinities

Protein Science, Volume 35, Issue 9, September 2026.
Abstract Somatic mutations and antibody clone selection occur in B‐cell hyper‐evolution over extremely brief periods of time. Herein, we developed a technique for antibody screening by immunizing alpacas with antigens and observing antibody sequence transitions over time, a method we named Tracking the Evolution of Antibodies over time.
Yoko Akazawa‐Ogawa, Tomonari Matsuda, Norihiko Kiyose, Nobuo Miyazaki, Tetsuo Fukuta, Motoyasu Adachi, Yuji Ito, Yoshihisa Hagihara   +7 more
wiley   +1 more source

IMGT, the International ImMunoGeneTics Information System

, 2011
INTRODUCTIONIMGT, the international ImMunoGeneTics information system (http://www.imgt.org), created in 1989 by the Laboratoire d’ImmunoGénétique Moléculaire LIGM (Université Montpellier 2 and CNRS, Montpellier, France), is the global reference in ...
Marie-Paule Lefranc, Lefranc, Mp
core   +1 more source

AVIDbase: A biologically accurate structural dataset of nanobody‐antigen complexes

Protein Science, Volume 35, Issue 9, September 2026.
Abstract Accurate structural data in a standardized format is one of the key factors behind the success of machine learning (ML)‐based methods for protein design and structure prediction. However, their application to nanobody‐antigen complexes has lower success rates compared to globular protein complexes, partly due to the limited amount of high ...
Tadej Medved, Jurij Lah, Goran Miličić, San Hadži   +3 more
wiley   +1 more source

IMGT/DomainGapAlign: IMGT Standardized Analysis of Amino Acid Sequences of Variable, Constant, and Groove Domains (IG, TR, MH, IgSF, MhSF)

, 2011
INTRODUCTIONIMGT/DomainGapAlign is the IMGT online tool for the analysis of amino acid (AA) sequences and two-dimensional (2D) structures of domains. The use of this tool is described here.
Marie-Paule Lefranc, Ehrenmann, François, Lefranc, Mp, François Ehrenmann   +3 more
core   +1 more source