Results 131 to 140 of about 63,325 (247)

Highly Active Cu14 Cluster Precisely Activates Autophagy Inhibitor to Amplify Cuproptosis Immunotherapy

Advanced Science, EarlyView.
An atomically precise Cu14 cluster‐mediated bond scission reaction pioneers the amplification of the antitumor immune response via synergetic cuproptosis‐associated immunogenic cell death induction and in situ autophagy blockade. ABSTRACT Transition metal‐mediated cleavage mechanisms have emerged as an effective means to mitigate the off‐target ...
Qiu‐Xu Zang, Wei‐Tong Chen, Yu‐Ying Shen, Zhao‐Yang Wang, Kai Li, Xueli Zhao, Yanjuan Sang, Xiaoyuan Chen, Shuang‐Quan Zang   +8 more
wiley   +1 more source

Synthesis and preclinical development of a novel ⁶⁸Ga/⁸⁹Zr-Labelled ανβ6-integrin targeting trimer. [PDF]

EJNMMI Radiopharm Chem
Gariglio G, A Patiño Álvarez F, A Zierke M, Stangl S, Rheinfrank T, Holzleitner N, Kossatz S, Decristoforo C.   +7 more
europepmc   +1 more source

Targeted Extracellular Vesicles Deliver Asiaticoside to Inhibit AURKB/DRP1‐Mediated Mitochondrial Fission and Attenuate Hypertrophic Scar Formation

Advanced Science, EarlyView.
Hypertrophic scar formation is driven by excessive mitochondrial fission in wound macrophages, which we discover is governed by a novel AURKB‐DRP1(Ser616) axis. The study develops a targeted therapy using cRGD‐decorated extracellular vesicles to deliver the natural compound Asiaticoside specifically to macrophages.
Luyu Li, Chenli Si, Xue Wang, Xiaojin Wu, Ying Shang, Shengfang Ge, Yong Wang, Yong Zuo, Zhen Zhang   +8 more
wiley   +1 more source

A comparative biodistribution and toxicity study of single and multi-component nanomaterials: NMs: TiO₂, SiC, and SiC@TiO₂. [PDF]

Part Fibre Toxicol
Zhang W, Ghouri MD, Blosi M, Liu Y, Chen C, Cassee FR, Cai R.   +6 more
europepmc   +1 more source

Oncolytic Probiotics with Molecular Pili for Solid Tumor Therapy

Advanced Science, EarlyView.
This study identifies Lactobacillus rhamnosus as an intrinsic oncolytic agent that triggers tumor metabolic collapse via calcium‐dependent ROS bursts. By chemically anchoring collagen‐targeting “molecular pili” to the bacterial surface, the engineered non‐transgenic probiotic (LR@MP) achieves targeted colonization and potent solid tumor suppression ...
Haodong Ge, Chengsheng Ding, Xiao Yang, Si Gao, Changjie Yang, Yuchen Hou, Hongye Wang, Linke Bian, Hao Zhong, Yifan Qu, Luyang Zhang, Junjun Ma, Zhengwei Cai, Wenguo Cui, Minhua Zheng   +14 more
wiley   +1 more source

Imaging-guided optimization of biodistribution and antitumor efficacy of L19-based immunocytokines. [PDF]

Transl Oncol
Virgilio T, Chahine K, Carreras JG, Pulfer A, Pizzichetti C, Latino I, Molina-Romero D, Capucetti A, Renner LL, Neri D, Puca E, De Luca R, Gonzalez SF.   +12 more
europepmc   +1 more source

Iron Oxide Nanozyme as Reactive Oxygen and Nitrogen Species Scavenger to Regulate Microglial Homeostasis in Stroke

Advanced Science, EarlyView.
6 nm iron oxide nanoparticles (IONP6) exhibit enzyme‐like activities that scavenge reactive oxygen and nitrogen species (RONS), including nitric oxide (NO). In stroke models, IONP6 promotes microglial polarization toward the M2 phenotype, reduces neuroinflammation, and improves neurological outcomes, offering a promising drug‐free approach to mitigate ...
Yilin Qi, Chunxiao Wang, Yuqing Miao, Jiamin Li, Zengyu Xun, Di Sun, Fei Xu, Minrui Liu, Heping Wang, Galong Li, Xuyi Chen, Haiming Fan, Xue Xue   +12 more
wiley   +1 more source

Investigating the Theranostic Potential of Elementally Matched [⁴³Sc]Sc-PSMA-617 and [⁴⁷Sc]Sc-PSMA-617. [PDF]

Mol Pharm
Cingoranelli SJ, Putnam E, Houson HA, Gimblet GR, Samuel S, Tekin V, Lapi SE.   +6 more
europepmc   +1 more source

Adipocyte‐Derived Exosomal miR‐5099 Mitigates M1 Macrophage Polarization and Adipose Inflammation via c‐Met/NF‐κB Axis to Improve Metabolic Health

Advanced Science, EarlyView.
Celastrol upregulates adipocyte‐derived exosomal miR‐5099, suppressing the macrophage c‐Met/NF‐κB axis to mitigate pro‐inflammatory M1 polarization and adipose inflammation. These miR‐5099‐enriched exosomes also act as endocrine signals targeting the liver, muscle, and adipocytes to significantly enhance systemic insulin sensitivity.
Ping Tang, Lixin Tai, Hongxia Xu, Dongliang Zhu, Jiajia Li, Hao Feng, Jinghui Cui, Shuhai Lin, Li‐jun Di, Li Wang   +9 more
wiley   +1 more source

Tetraspanin-8 as a Tumor-Selective Immuno-PET Target in Hepatocellular Carcinoma. [PDF]

J Nucl Med
Sheehan-Klenk J, Makala H, Chung JY, Lee W, Baidoo KE, Nambiar D, Alani N, Hewitt SM, Ueda Y, Omiya S, Escorcia FE.   +10 more
europepmc   +1 more source