Results 111 to 120 of about 97,326 (260)

Preparation of ¹⁴C-Labeled Multiwalled Carbon Nanotubes for Biodistribution Investigations

, 2016
Preparation of 14C-Labeled Multiwalled Carbon Nanotubes for Biodistribution ...
Bertrand Czarny (1597735), Marie Carriere (111653), Jean-Luc Poncy (2343451), Mathieu Pinault (1689196), Brigitte Bouchet-Fabre (2343457), Frédéric Taran (1688335), Quang Chau (2343460), Dominique Georgin (1788301), Rémy Maximilien (2343466), Vincent Dive (256588), Magali Botquin (2343454), Martine Mayne-L’Hermite (2343463)   +11 more
core   +1 more source

Intranasal Delivery of Gallium–Quercetin Nanoparticles for Multi‐Target Ferroptosis Inhibition in Parkinson's Disease

Advanced Science, EarlyView.
Leveraging the chemical similarity between Ga3+ and Fe3+ as well as the antioxidant properties of quercetin, gallium–quercetin nanoparticles (GQNPs) were prepared to integrate iron homeostasis regulation, oxidative stress suppression, and mitochondrial protection for multi‐target ferroptosis inhibition in Parkinson's Disease.
Keyang Xu, Dandan Kou, Xiao Xiao, Bingbing Bai, Caide Liu, Mengyao Wu, Yadan Shi, Mengdan Xu, Xiaoyi Cao, Haodi Qi, Shuhua Wu, Jianfeng Zeng, Mingyuan Gao   +12 more
wiley   +1 more source

Development and biodistribution of a theranostic aluminum phthalocyanine nanophotosensitizer

, 2016
Background: Aluminum phthalocyanine (AlPc) is an efficient second generation photosensitizer (PS) with high fluorescence ability. Its use in photodynamic therapy (PDT) is hampered by hydrophobicity and poor biodistribution. Methods: AlPc was converted to
Asem, Heba,, Muhammed, Mamoun,, Hassan, Moustapha, Khalil, Labiba, Abd El-Fattah, Ahmed, Kandil, Sherif, Nafee, Noha, Zhao, Ying, Nafee, N, Muhammed, M, Asem, H, Khalil, L, Zhao, Y,, Hassan, M,, Abd, El-Fattah A, Kandil, S   +15 more
core   +1 more source

Modification‐Selective Inhibition of Succinate Dehydrogenase a Enables Tumor‐Restricted Mitochondrial Modulation

Advanced Science, EarlyView.
This work identifies acetylation‐dependent SDHA homeostasis as a determinant of tumor‐specific metabolic vulnerability. Guided by this mechanism, a modification‐selective inhibitor, ZPI‐3, selectively targets non‐acetylated SDHA, achieving tumor‐restricted SDH inhibition and effective bladder cancer control. Differential responses in clinical specimens
Kaikai Xu, Lulu Kong, Kebin Ye, Xinlu Bao, Haowen Liu, Ning Wang, Yongming Deng, Wei Wang, Shaohua Wei, Lin Zhou   +9 more
wiley   +1 more source

Biodistribution data for 4.

, 2016
Data are presented as the mean (± SEM) percent injected dose per gram (%ID/g) for selected tissues and fluids from CD1 mice at 0.5, 1, 2 and 6 h post injection (n = 3 per time point). Approximately 0.88 MBq were administered per mouse.
Megan Blacker (1428724), John F. Valliant (1428703), Nancy Janzen (1428712), Afaf R. Genady (1566097), Lisset Llano (3390371), Alyssa Vito (1428727), Stephanie Rathmann (3390380), Paul J. Berti (2056342), Zoya Naperstkow (3390386), Hussain Alarabi (3390383), Omid Beiraghi (3390377), Salma A. Alkarmi (3390374), Shannon Czorny (1655416), Jeff Kent (1929649)   +13 more
core   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau

Advanced Science, EarlyView.
TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun, Yang Liu, Qiuzhi Zhou, Qingyuan Hu, Weixia Wang, Yue Xiao, Jingfen Su, Guanting Liu, Miaomiao Sun, Lixia Chen, Hua Li, Ying Yang, Jian‐Zhi Wang   +12 more
wiley   +1 more source

Distinct Proteins in Protein Corona of Nanoparticles Represent a Promising Venue for Endogenous Targeting – Part II: In vitro and in vivo Kinetics Study

International Journal of Nanomedicine, 2020
Aya Ahmed Sebak,1 Iman Emam Omar Gomaa,2 Aliaa Nabil ElMeshad,3 Mahmoud Hussien Farag,1 Ulrike Breitinger,4 Hans-Georg Breitinger,4 Mahmoud Hashem AbdelKader5,6 1Pharmaceutical Technology Department, Faculty of Pharmacy and Biotechnology, German ...
Sebak AA, Gomaa IEO, ElMeshad AN, Farag MH, Breitinger U, Breitinger H, AbdelKader MH   +6 more
doaj  

Kidney‐Targeted Cilastatin Nanoparticles Inhibit DPEP1‐Mediated Ferroptosis for Acute Kidney Injury Therapy

Advanced Science, EarlyView.
In this study, MPDA NPs were engineered to encapsulate CTT. To further increase renal accumulation of CTT, L‐serine was conjugated to the surface of the MPDA nanoparticles (CTT/MPDA@L‐Ser NPs). CTT/MPDA@L‐Ser NPs inhibit DPEP1 activity, thereby restoring ferroptosis defense mechanisms through upregulation of GPX4 and SLC7A11 expression, ultimately ...
Wanbing Qin, Jiaqi Huang, Manting Zhang, Wanchun Yang, Mingwei Xu, Chi Jiang, Jiekai Li, Jinjuan Wen, Qibin Huang, Shiqi Wen, Weidong Wang, Junbing He, Qinghua Liu   +12 more
wiley   +1 more source

In vivo biodistribution of [18F]PSMA-derivative radiopharmaceuticais in GBM preclinical models

, 2022
In vivo biodistribution of [18F]PSMA-derivative radiopharmaceuticais in GBM preclinical ...
Sergio Todde, Paolo Rainone, Rosa Maria Moresco, Silvia Valtorta, Valentina Zecca, Elia Anna Turolla, Marco Iannone, Stefano Stucchi   +7 more
core