Results 131 to 140 of about 92,303 (298)

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

Distinct Proteins in Protein Corona of Nanoparticles Represent a Promising Venue for Endogenous Targeting – Part II: In vitro and in vivo Kinetics Study

International Journal of Nanomedicine, 2020
Aya Ahmed Sebak,1 Iman Emam Omar Gomaa,2 Aliaa Nabil ElMeshad,3 Mahmoud Hussien Farag,1 Ulrike Breitinger,4 Hans-Georg Breitinger,4 Mahmoud Hashem AbdelKader5,6 1Pharmaceutical Technology Department, Faculty of Pharmacy and Biotechnology, German ...
Sebak AA, Gomaa IEO, ElMeshad AN, Farag MH, Breitinger U, Breitinger H, AbdelKader MH   +6 more
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Biodistribution data for 4.

, 2016
Data are presented as the mean (± SEM) percent injected dose per gram (%ID/g) for selected tissues and fluids from CD1 mice at 0.5, 1, 2 and 6 h post injection (n = 3 per time point). Approximately 0.88 MBq were administered per mouse.
Megan Blacker (1428724), John F. Valliant (1428703), Nancy Janzen (1428712), Afaf R. Genady (1566097), Lisset Llano (3390371), Alyssa Vito (1428727), Stephanie Rathmann (3390380), Paul J. Berti (2056342), Zoya Naperstkow (3390386), Hussain Alarabi (3390383), Omid Beiraghi (3390377), Salma A. Alkarmi (3390374), Shannon Czorny (1655416), Jeff Kent (1929649)   +13 more
core   +1 more source

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

Advanced Science, EarlyView.
The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei, Junchao Cai, Zhenshuang Du, Tianfeng Chen, Weiling He   +13 more
wiley   +1 more source

Celastrol‐Loaded Conductive Hydrogel Mitigates Myocardial Ischemia‐Reperfusion Injury and Restores Electrophysiological Function

Advanced Science, EarlyView.
Schematic illustration of the Pluronic F127 diacrylate/gelatin methacryloyl/poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate)/celastrol hydrogel (FGPC) for localized myocardial ischemia–reperfusion injury treatment. FGPC combines sustained celastrol delivery with PEDOT:PSS‐mediated conductive support to attenuate acute oxidative/inflammatory ...
Shixin Wang, Shaojie Chen, Chengzong Li, Hongyi Cheng, Jincheng Jiao, Xiafeng Peng, Yike Zhang, Wei Sun, Feng Zhang, Chang Cui, Minglong Chen   +10 more
wiley   +1 more source

Biodistribution of different nanocarriers in murine myoblasts

, 2017
biodistribution study on biocompatible nanocarriers in murine ...
L. Calderan, M. Malatesta, F. Boschi, M. Costanzo, B. Stella, B. Cisterna, S. Arpicco, VURRO, FEDERICA, G. Berlier, A. Marengo   +9 more
core   +1 more source

Preparation, pharmacokinetics and biodistribution of baicalin-loaded liposomes

, 2014
Yumeng Wei,1,* Jianmin Guo,2,* Xiaoli Zheng,2,* Jun Wu,3 Yang Zhou,1 Yu Yu,4 Yun Ye,1 Liangke Zhang,4 Ling Zhao11School of Pharmacy, 2Institute of Basic Medical Sciences, Luzhou Medical College, Luzhou City ...
Wu J, Zheng X, Zhao L, Guo J, Zhang L, Zhou Y, Ye Y, Wei Y, Yu Y   +8 more
core  

Biodistribution imaging of a paclitaxel-hyaluronan bioconjugate

, 2009
INTRODUCTION: Gamma-ray detectors represent sensitive and noninvasive instruments to evaluate in vivo the metabolic trapping of radiopharmaceuticals.
ROSATO, ANTONIO, RENIER D, BANZATO, ALESSANDRA, RONDINA, MARIA, MAZZI, ULDERICO, ZANOVELLO, PAOLA, ZANGONI E, MOSCHINI, GIULIANO, MELENDEZ ALAFORT L, NADALI A   +9 more
core   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Accumulation and biodistribution of gold nanoparticles in the mesenteric lymph nodes at oral administration

Russian Open Medical Journal, 2013
The aim: to conduct analysis of the accumulation and biodistribution of gold nanoparticles in the structural and functional areas of mesenteric lymph nodes of white rats conducted with regard to the size and duration of the oral administration.
Olga V. Zlobina, Svetlana S. Pakhomiy, Alla B. Bucharskaya, Irina O. Bugaeva, Galina N. Maslyakova, Nikolai G. Khlebtsov, Boris N. Khlebtsov, Vladimir A. Bogatyrev   +7 more
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