Results 91 to 100 of about 97,326 (260)

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Biodistribution und Pharmakokinetik von 99mTc-markiertem Elafin im Rattenmodell [PDF]

, 2016
Die Biodistribution und Pharmakokinetik des humanen Protein Elafin, das ein potenter inhibitor der proinflammatorischen Leukozyten-elastase, der Protease 3 und der endogenen vaskulären Elastase ist, wurde nach Markierung mit Technetium-99m und ...
Tjiong, Angelina Larissa
core   +1 more source

Development of 111In-labeled porphyrins for SPECT imaging [PDF]

Asia Oceania Journal of Nuclear Medicine and Biology, 2014
Objectives: The aim of this research was the development of 111In-labeled porphyrins as possible radiopharmaceuticals for the imaging of tumors. Methods: Ligands, 5, 10, 15, 20-tetrakis (3, 5-dihydroxyphenyl) porphyrin) (TDHPP), 5, 10, 15, 20-tetrakis (4-
Shaghayegh Sadeghi, Mohammad Mirzaei, Mohammad Rahimi, Amir Jalilian   +3 more
doaj  

Biodistribution and pharmacokinetics of 188Re-liposomes and their comparative therapeutic efficacy with 5-fluorouracil in C26 colonic peritoneal carcinomatosis mice

, 2011
Chia-Che Tsai1, Chih-Hsien Chang1, Liang-Cheng Chen1, Ya-Jen Chang1, Keng-Li Lan2, Yu-Hsien Wu1, Chin-Wei Hsu1, I-Hsiang Liu1, Chung-Li Ho1, Wan-Chi Lee1, Hsiao-Chiang Ni1, Tsui-Jung Chang1, Gann Ting3, Te-Wei Lee11Institute of Nuclear Energy Research ...
null Chia-Che Tsai, gann ting, null Yu-Hsien Wu, null Liang-Cheng Chen, null Chin-Wei Hsu, Chang CH, null Keng-Li Lan, Hsu CW, Wu YH, Lan KL, Chen LC, Tsai CC, Te-Wei Lee, Lee TW, null Ya-Jen Chang, Ni HC, null Chih-Hsien Chang, null I-Hsiang Liu, Chang YJ, Ting G, null Chung-Li Ho, Liu IH, Ho CL, Lee WC, null Hsiao-Chiang Ni, Tsai, CC;Chang, CH;Chen, LC;Chang, YJ;Lan, KL;Wu, YH;Hsu, CW;Liu, IH;Ho, CL;Lee, WC;Ni, HC;Chang, TJ;Ting, G;Lee, TW, null Wan-Chi Lee, null Tsui-Jung Chang, Chang TJ   +28 more
core   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Biodistribution of nanocapsules in bovine mammary gland model. [PDF]

, 2012
The determination of the biodistribution of pharmaceutical formulations is important to ensure that the drug reaches all the tissue to be treated. Recent studies demonstrated that udder ex situ may be used to assess the biodistribution of intramammary ...
BRANDI, R. R., CALVINHO, L. C., MENDONCA, L. C., CASTANHEIRA, R. G., MOSQUEIRA, V. C. F., LANGE, C. C., SOUZA, G. N. de, BRANDAO, H. de M., GERN, J. C., GUIMARAES, A. S., ANDRADE, P. V. D.   +10 more
core  

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Ultra‐Radiostable Covalent Conformationally Interlocked Networks Enabling a Universal Radiometal‐Labeling Platform for Cancer Radioembolization

Advanced Science, EarlyView.
Conjugated poly(imide dioxime)‐based microspheres establish a radiometal coordination‐driven conformational interlocked network with ultra‐high radiostability. This platform enables low‐temperature, multi‐radionuclide labeling for SPECT/PET/MRI imaging and radionuclide therapy. Mechanistic insights from EXAFS and DFT reveal enhanced stability, while in
Xiao Xu, Zhenwen Zhao, Yangjie Wang, Zhigang Liu, Zhijie Liu, Xiaoling Li, Zhichen Mao, Lu Xu, Gan Lin, Gang Liu, Hongjuan Ma   +10 more
wiley   +1 more source

Visual tracing of diffusion and biodistribution for amphiphilic cationic nanoparticles using photoacoustic imaging after ex vivo intravitreal injections

, 2016
Xu Xu,* Zhaokang Xu,* Junyi Liu, Zhaoliang Zhang, Hao Chen, Xingyi Li, Shuai Shi Institute of Biomedical Engineering, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of ...
Zhang ZL, Shi S, Xu ZK, Liu JY, Chen H, Li XY, Xu X   +6 more
core  

Concerted Action of Targeted Nucleic Acid Therapeutics as Flexible, Precision and Personalized Cancer Treatment

Advanced Science, EarlyView.
Combinations of small activating RNAs and small interfering RNAs were developed as personalized precision therapies that simultaneously activate tumor suppressors and silence oncogenes according to the molecular signatures of patient tumors. This combination strategy demonstrated superior anticancer efficacy, highlighting the promise of precision ...
Jing Wu, Jiaxuan Chen, Abdechakour Elkihel, Wenjun Lan, Nicolas Fraunhoffer, Dandan Zhu, Baoping Lian, Christina Galanakou, Zhancun Bian, Xi Liu, Odile Gayet, Loic Moubri, Julie Aglietti Roques, Vikash Reebye, Nagy Habib, Xiaoxuan Liu, Nelson Dusetti, Juan Lucio Iovanna, Ling Peng   +18 more
wiley   +1 more source