Results 71 to 80 of about 119,908 (286)

Dual‐Peptide Nanoplatform: Mesoporous Silica Nanoparticles Functionalized With a Cell‐Penetrating Peptide and Loaded With Rationally Designed Antimicrobial Peptides for Tuberculosis Therapy

Advanced Healthcare Materials, EarlyView.
Machine learning–guided engineering of a plectasin‐derived peptide yields DC05, a potent antimycobacterial candidate. Encapsulation into tuftsin‐functionalized mesoporous silica nanoparticles enhances intracellular delivery, stability, and activity against Mycobacterium tuberculosis while maintaining low cytotoxicity and minimal hemolysis. The combined
Christian S. Carnero Canales, Cesar Augusto Roque‐Borda, Ana Carolina Cerqueira Negri, Oswaldo Ramirez Delgado, Letícia Oliveira Catarin Nunes, Flávia Aparecida Resende, Hernane Barud, Norival Alves Santos‐Filho, Saulo Santesso Garrido, Karen Cristina Oliveira, Alexandra Ivo de Medeiros, Rafael Miguel Sábio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

The 3M Concept: Biomedical Translational Imaging from Molecules to Mouse to Man

The EuroBiotech Journal, 2021
Imaging keeps pervading biomedical sciences from the nanoscale to the bedside. Connecting the hierarchical levels of biomedicine with relevant imaging approaches, however, remains a challenge.
Máthé Domokos, Kiss Bálint, Pályi Bernadett, Kis Zoltán, Forgách László, Hegedűs Nikolett, Varga Zoltán, Szigeti Krisztián, Karlinger Kinga, Kellermayer Miklós S Z   +9 more
doaj   +1 more source

Particle Engineering of Innovative Nanoemulsion Designs to Modify the Accumulation in Female Sex Organs by Particle Size and Surface Charge

Pharmaceutics, 2022
Particle engineering of nanosized drug delivery systems (DDS) can be used as a strategic tool to influence their pharmacokinetics after intravenous (i.v.) application by the targeted adaptation of their particle properties according to the needs at their
Eike Folker Busmann, Henrike Lucas
doaj   +1 more source

Absorbed radiation dosimetry of the D3-specific PET radioligand [18F]FluorTriopride estimated using rodent and nonhuman primate [PDF]

, 2016
[(18)F]FluorTriopride ([(18)F]FTP) is a dopamine D(3)-receptor preferring radioligand with potential for investigation of neuropsychiatric disorders including Parkinson disease, dystonia and schizophrenia. Here we estimate human radiation dosimetry for [(
Bognar, Christopher, Flores, Hubert P, Karimi, Morvarid, Laforest, Richard, Li, Aixiao, Mach, Robert H, Moerlein, Stephen M, Perlmutter, Joel S, Tu, Zhude, Xu, Jinbin   +9 more
core   +1 more source

Blood clearance and tissue distribution of PEGylated and non-PEGylated gold nanorods after intravenous administration in rats\ud [PDF]

, 2011
Aims: To develop and determine the safety of gold nanorods, whose aspect ratios can be tuned to obtain plasmon peaks between 650 and 850 nm, as contrast enhancing agents for diagnostic and therapeutic applications.
Jong, Wim H. de, Krystek, Petra, Lankveld, Danielle P.K., Leeuwen, Ton G. van, Manohar, Srirang, Oomen, Agnes G., Rayavarapu, Raja G., Verharen, Hennie W.   +7 more
core   +4 more sources

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, EarlyView.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source

Toxicology and efficacy of tumor-targeting Salmonella typhimurium A1-R compared to VNP 20009 in a syngeneic mouse tumor model in immunocompetent mice. [PDF]

, 2017
Salmonella typhimurium A1-R (S. typhimurium A1-R) attenuated by leu and arg auxotrophy has been shown to target multiple types of cancer in mouse models.
Cao, Wenluo, Dry, Sarah M, Eilber, Fritz C, Hoffman, Robert M, Kiyuna, Tasuku, Li, Shukuan, Li, Yunfeng, Ma, Huaiyu, Murakami, Takashi, Nelson, Scott D, Singh, Arun S, Toneri, Makoto, Wang, Xiaoen, Zhang, Nan, Zhang, Yong, Zhao, Ming   +15 more
core   +1 more source

Mapping Nanoscale Protein‐Corona Kinetics of DoE‐Optimized Perfluorocarbon Encapsulated‐PLGA Nanoparticles by In Situ, Time‐Resolved Synchrotron SAXS

Advanced Healthcare Materials, EarlyView.
A two‐phase workflow (OFAT screening followed by central composite design) maps how processing variables tune PFCE‐PLGA nanoparticle size, dispersity, surface charge, loading, and 19F‐MRI signal. In situ, time‐resolved synchrotron SAXS tracks albumin‐corona growth on intact dispersions and reveals PFCE‐dependent adsorption pathways.
Joice Maria Joseph, Maria Rosa Gigliobianco, Cristina Minnelli, Paolo Moretti, Francesco Spinozzi, Giovanna Mobbili, Sara Pistolesi, Cristina Casadidio, Gabriella Teti, Roberta Censi, Stefano Antonio Gattone, Piera Di Martino   +11 more
wiley   +1 more source

Toxicity, biodistribution and oxidative damage caused by zirconia nanoparticles after intravenous injection

International Journal of Nanomedicine, 2019
Yue Yang,1,2 Huihui Bao,1 Qianqian Chai,3 Zhiwen Wang,2 Zhenning Sun,2 Changhui Fu,3 Zhaoping Liu,1 Zhongjie Liu,2 Xianwei Meng,3 Tianlong Liu21China National Center for Food Safety Risk Assessment, Beijing 100022, People’s Republic of China ...
Yang Y, Bao H, Chai Q, Wang Z, Sun Z, Fu C, Liu Z, Liu Z, Meng X, Liu T   +9 more
doaj  

Exposure to Inorganic Nanoparticles: Routes of Entry, Immune Response, Biodistribution and In Vitro/In Vivo Toxicity Evaluation

Toxics, 2017
The development of different kinds of nanoparticles, showing different physico-chemical properties, has fostered their large use in many fields, including medicine.
Valeria De Matteis
doaj   +1 more source