Results 71 to 80 of about 92,303 (298)

Nanomaterial Strategies for Pulmonary Delivery of Immunotherapeutics in Lung Cancer Treatment

Advanced Healthcare Materials, EarlyView.
Inhalable immunotherapeutic nanomedicines enable organ‐selective immune modulation by overcoming pulmonary delivery barriers and concentrating therapy within lung tumors. This Review defines how nanomaterial properties govern airway deposition, retention, cellular partitioning, and immune activation across vaccines, checkpoint blockade, STING agonists,
Han Zhang, Wei Tang
wiley   +1 more source

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin B. Waghamode, Shubham Khot, Rajiya Khan, Ravi Hole, Shankar M. Dhobale, Manoj Aswar, Keshav Raj Paudel   +8 more
wiley   +1 more source

Toxicity, biodistribution and oxidative damage caused by zirconia nanoparticles after intravenous injection

International Journal of Nanomedicine, 2019
Yue Yang,1,2 Huihui Bao,1 Qianqian Chai,3 Zhiwen Wang,2 Zhenning Sun,2 Changhui Fu,3 Zhaoping Liu,1 Zhongjie Liu,2 Xianwei Meng,3 Tianlong Liu21China National Center for Food Safety Risk Assessment, Beijing 100022, People’s Republic of China ...
Yang Y, Bao H, Chai Q, Wang Z, Sun Z, Fu C, Liu Z, Liu Z, Meng X, Liu T   +9 more
doaj  

Exposure to Inorganic Nanoparticles: Routes of Entry, Immune Response, Biodistribution and In Vitro/In Vivo Toxicity Evaluation

Toxics, 2017
The development of different kinds of nanoparticles, showing different physico-chemical properties, has fostered their large use in many fields, including medicine.
Valeria De Matteis
doaj   +1 more source

A Guide to Ex Vivo Biodistribution Studies with Radiotracers in Rodent Models

Preclinical biodistribution studies are required at an early stage of radiopharmaceutical development to determine tracer pharmacokinetics in clinically relevant animal models of human diseases.
Sarparanta, Mirkka, Poty, Sophie, Holland, Jason P., Imlimthan, Surachet, Berton, Cesare   +4 more
core   +1 more source

Biodistribution of neural stem cells after intravascular therapy for hypoxic-ischemia

, 2010
Intravascular transplantation of neural stem cells represents a minimally invasive therapeutic approach for the treatment of central nervous system diseases. The cellular biodistribution after intravascular injection needs to be analyzed to determine the
Chen, Shawn, Arjun V. Pendharkar, Chua, Josh Y, Robert H. Andres, Hui Wang, De, Abhijit, Raymond Choi, Wang, Hui, Andres, Robert H, Choi, Raymond, Shawn Chen, Rutt, Brian K, Brian K. Rutt, Wang, Nancy, Gambhir, Sanjiv S, Nancy Wang, Abhijit De, Raphael Guzman, Xavier Gaeta, Guzman, Raphael, Josh Y. Chua, Sanjiv S. Gambhir, Pendharkar, Arjun V, Gaeta, Xavier   +23 more
core   +1 more source

Tumor‐Targeted Hyaluronic Acid/Tannic Acid‐Engineered Oxygen Nanogenerators With IR780 Payloads Enable Dual‐Mode Glutathione Depletion and Effective Singlet Oxygen Generation for Melanoma Treatment

Advanced Healthcare Materials, EarlyView.
A hyaluronic acid/tannic acid‐engineered Prussian blue oxygen nanogenerator loaded with IR780 is developed to enhance melanoma phototherapy. By integrating tumor targeting, oxygen self‐supply, and dual‐mode glutathione depletion, the nanoplatform effectively overcomes hypoxia and antioxidant defenses, potentiating synergistic photothermal/photodynamic ...
Chai‐How Hsu, I‐Ju Liu, Hsiang‐Yun Chih, Tsai‐Ching Hsu, Ju‐An Liang, Chia‐Wei Kuo, Bor‐Show Tzang, Wen‐Hsuan Chiang   +7 more
wiley   +1 more source

Epidermal Delivery of Retinyl Palmitate Loaded Transfersomes: Penetration and Biodistribution Studies

Pharmaceutics, 2020
The alteration of retinoids levels in the skin can cause different disorders in the maturation of epithelial skin cells. Topical administration of these lipophilic molecules is a challenge that can be addressed by encapsulation into drug delivery systems.
Eloy Pena-Rodríguez, Mari Carmen Moreno, Bárbara Blanco-Fernandez, Jordi González, Francisco Fernández-Campos   +4 more
doaj   +1 more source

Overcoming Photodynamic Therapy Resistance: GSH‐Responsive AIE Photosensitizer‐Hydroxycamptothecin Nanoliposomes for Extrahepatic Cholangiocarcinoma

Advanced Healthcare Materials, EarlyView.
A GSH‐responsive AIE nanoplatform (TSH NPs) with RGD‐mediated tumor targeting co‐delivers a photosensitizer (TPA) and HCPT for extrahepatic cholangiocarcinoma. The system synergistically enhances PDT and chemotherapy by suppressing HIF‐1α/VEGF‐driven hypoxic adaptation, effectively overcoming PDT resistance.
Yong Qu, Tao Peng, Yating Zhang, Juanmei Cao, Birong Wang, Chuxing Chai, Zhiyuan Gao, Yiting Xu, Yifan Jin, Yuqing Wang, Zhuoxia Li, Xu Liu, Tianqi Zhao, Yufan Chen, Weimin Lv, Di Lu, Changzheng Huang, Dan Ding, Jinxiang Zhang, Min Li   +19 more
wiley   +1 more source

Quantification of extracellular vesicles in vitro and in vivo using sensitive bioluminescence imaging

Journal of Extracellular Vesicles, 2020
Extracellular vesicles (EVs) are naturally occurring nano-sized carriers that are secreted by cells and facilitate cell-to-cell communication by their unique ability to transfer biologically active cargo.
Dhanu Gupta, Xiuming Liang, Svetlana Pavlova, Oscar P.B Wiklander, Giulia Corso, Ying Zhao, Osama Saher, Jeremy Bost, Antje M. Zickler, Andras Piffko, Cecile L. Maire, Franz L. Ricklefs, Oskar Gustafsson, Virginia Castilla Llorente, Manuela O. Gustafsson, R. Beklem Bostancioglu, Doste R Mamand, Daniel W. Hagey, André Görgens, Joel Z. Nordin, Samir EL Andaloussi   +20 more
doaj   +1 more source