Results 61 to 70 of about 119,908 (286)

Electrostatic properties of human germlines and biodistribution of small biologics

mAbs
Off-target biodistribution of biologics bears important toxicological consequences. Antibody fragments intended for use as vectors of cytotoxic payloads (e.g.
Leticia Maria De Souza Cordeiro, Kelley Christine Atkinson, Argin Aivazian, Patrick Frank Joyce, Fang Jia, Alessandro Mascioni   +5 more
doaj   +1 more source

Enhancement of antifungal activity and transdermal delivery of 5-flucytosine via tailored spanlastic nanovesicles: statistical optimization, in-vitro characterization, and in-vivo biodistribution study

Frontiers in Pharmacology, 2023
Aim and background: This current study aimed to load 5-flucytosine (5-FCY) into spanlastic nanovesicles (SPLNs) to make the drug more efficient as an antifungal and also to load the 5-FCY into a hydrogel that would allow for enhanced transdermal ...
Awaji Y. Safhi, Nimbagal Raghavendra Naveen, Krishna Jayanth Rolla, Penmetsa Durga Bhavani, Mallesh Kurakula, Khaled M. Hosny, Walaa A. Abualsunun, Mohammed Alissa, Abdullah Alsalhi, Amerh Aiad Alahmadi, Khalid Zoghebi, Abdulrahman Sindam Halwaani, Rasha Ibrahim K   +12 more
doaj   +1 more source

Optimizing CIGB-300 intralesional delivery in locally advanced cervical cancer [PDF]

, 2015
Background:We conducted a phase 1 trial in patients with locally advanced cervical cancer by injecting 0.5 ml of the CK2-antagonist CIGB-300 in two different sites on tumours to assess tumour uptake, safety, pharmacodynamic activity and identify the ...
A Perera, A Prats, A Rodriguez-Ulloa, A Siddiqui-Jain, AM Solares, B E Acevedo, C A Casacó, C M Valenzuela, CA Naranjo, D F Alonso, F Piazza, I Baladrón, I García, I Hernández, J A Ancízar, JA Siegel, JL Soriano-García, JS Duncan, KA Ahmad, L A Torres, L González, L Molina, M A Coca, M R Sarduy, M Solares, P A López-Saura, P Therasse, R Gómez, R Prudent, RE Carter, S E Perea-Rodríguez, S Tawfic, SE Perea, SE Perea, SE Perea, V Reyes, Y M González, Y M Martínez, Y Perera, Y Perera, Y Perera, Y Perera   +41 more
core   +2 more sources

Lysosome‐Acidifying Nanoparticles Rescue A30P α‐Synuclein Induced Neuronal Death in Cellular and Drosophila Models of Parkinson's Disease

Advanced Healthcare Materials, EarlyView.
Lysosome‐targeted acidic nanoparticles based on a biodegradable poly(ethylene tetrafluorosuccinate‐co‐succinate) copolymer are engineered to restore impaired lysosomal acidification through pH‐responsive intracellular degradation. Localized acid release enhances autophagic proteolysis, reduces α‐synuclein accumulation, and preserves dopaminergic neuron
Chih Hung Lo, Mengda Ren, Gavin Wen Zhao Loi, Eka Norfaishanty Saipuljumri, Jonathan Indajang, Kah Leong Lim, Jialiu Zeng   +6 more
wiley   +1 more source

^99mTc-Labeled Iron Oxide Nanoparticles as Dual-Modality Contrast Agent: A Preliminary Study from Synthesis to Magnetic Resonance and Gamma-Camera Imaging in Mice Models

Nanomaterials, 2022
The combination of two imaging modalities in a single agent has received increasing attention during the last few years, since its synergistic action guarantees both accurate and timely diagnosis.
Maria-Argyro Karageorgou, Aristotelis-Nikolaos Rapsomanikis, Marija Mirković, Sanja Vranješ-Ðurić, Efstathios Stiliaris, Penelope Bouziotis, Dimosthenis Stamopoulos   +6 more
doaj   +1 more source

Imaging Microglial/Macrophage Activation in Spinal Cords of Experimental Autoimmune Encephalomyelitis Rats by Positron Emission Tomography Using the Mitochondrial 18kDa Translocator Protein Radioligand [18F]DPA-714 [PDF]

, 2012
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the CNS. Activated microglia/macrophages play a key role in the immunopathogenesis of MS and its corresponding animal models, experimental autoimmune encephalomyelitis (EAE).
Abourbeh, Galith, Boisgard, Raphael, Brulon, Vincent, Dollé, Frédéric, Dubois, Albertine, Fontyn, Yoann, Maroy, Renaud, Tavitian, Bertrand, Thézé, Benoit   +8 more
core   +2 more sources

Characterization of an Injectable Poly(vinyl alcohol)‐gelatin Hydrogel for Growth Factor Delivery in an Orthopedic Application

Advanced Healthcare Materials, EarlyView.
This work introduces photo‐crosslinkable tyraminated poly(vinyl alcohol)‐gelatin (PVA‐GT) hydrogels as tunable injectable platforms for tissue engineering and growth factor delivery applications. This schematic illustrates the two developed hydrogel formulations and the experimental workflow used to evaluate their physico‐chemical properties in vitro ...
Alessia Longoni, Gretel S. Major, Sam Arnold, Samuel Tomkins, Eugenia Spessot, Scott Loeffler, Kieran Lau, Richard Tan, Jessica Harte, Roslyn Kemp, Tess Reynolds, Jelena Rnjak‐Kovacina, Gary J. Hooper, Tim B. F. Woodfield, David C. Kieser, Khoon S. Lim   +15 more
wiley   +1 more source

New amino bisphosphonate compound for skeletal imaging: Comparison study with methylenediphosphonic acid (MDP) and (1-hydroxyethane-1,1-diyl) diphosphonic acid (HEDP)

Nukleonika, 2016
A novel bisphosphonate derivative (1-aminoethane-1,1-diyl)diphosphonic acid (AEDP) has been prepared and successfully labeled with 99mTc at high labeling yields.
Assaad Thaer
doaj   +1 more source

Clove Oil-Nanostructured Lipid Carriers: A Platform of Herbal Anesthetics in Whiteleg Shrimp (Penaeus vannamei)

Foods, 2022
Whiteleg shrimp (Penaeus vannamei) have been vulnerable to the stress induced by different aquaculture operations such as capture, handling, and transportation.
Somrudee Kaewmalun, Teerapong Yata, Sirikorn Kitiyodom, Jakarwan Yostawonkul, Katawut Namdee, Manoj Tukaram Kamble, Nopadon Pirarat   +6 more
doaj   +1 more source

Biophysical and biochemical characterization of a liposarcoma-derived recombinant MnSOD protein acting as an anticancer agent [PDF]

, 2008
A recombinant MnSOD (rMnSOD) synthesized by specific cDNA clones derived from a liposarcoma cell line was shown to have the same sequence as the wild-type MnSOD expressed in the human myeloid leukaemia cell line U937, except for the presence of the ...
A. BORRELLI, A. MANCINI, A. SCHIATTARELLA, D. PAGNOZZI, F. MORELLI, GRIECO, PAOLO, J. ROMMELAERE, L. ALOJ, LORIZIO, ROBERTO, M. AURILIO, MAZZARELLA, LELIO, NOVELLINO, ETTORE, OCCHIELLO, ANTONELLA, PICA, ALESSANDRA, PUCCI, PIETRO, R. MANCINI, SICA, ALESSANDRO, SICA, FILOMENA   +17 more
core   +2 more sources