Results 41 to 50 of about 92,303 (298)

Biodistribution of VSX-1.

, 2023
(A) In vivo imaging of VSX-1’s biodistribution. Labeled VSX (the antibody alone) or VSX-1 (the ADC) was administered to animals IP and monitored by imaging up until 48 hours post-injection (h.p.i.). Both agents distributed throughout the animal (i.e.
Kenneth Johnson (830129), Bradley L. Pentelute (1247046), Faycal Touti (16949388), Zachary Shriver (228536), Surin Mong (16949382), Hamid Tissire (16949385), Jennifer Varin-Simon (6010544), Gregory J. Babcock (16949391), Andrew Wollacott (9547789), Karthik Viswanathan (182754), David Skurnik (454610), Obadiah Plante (9547792), James C. Delaney (551875), Thomas Guillard (296088), Fany Reffuveille (567572), Kai Li (205203), Eric Frapy (89685)   +16 more
core   +1 more source

Distribution and metabolism of iPSC-MSCs in the joint cavity of an osteoarthritis rat model

Frontiers in Bioengineering and Biotechnology
IntroductionTo investigate the metabolism and distribution of iPSC‐MSCs in the joint cavity of rats with knee osteoarthritis (KOA).MethodsThe iPSC‐MSCs labeled with the Antares2 luciferase gene were injected into the knee joints of rats, and then the ...
Xiaoyang Yuan, Xulei Wang, Xulei Wang, Tianxi Du, Feng Zhang, Gang Cheng, Kang Wang, Haochen Xu, Pingting Yang, Yan Chang, Wei Wei, Peng He, Shangxue Yan, Shangxue Yan   +13 more
doaj   +1 more source

Radioactive Labeling of Milk-Derived Exosomes with ^99mTc and In Vivo Tracking by SPECT Imaging

Nanomaterials, 2020
Over the last decade, exosomes from diverse biological sources have been proposed as new natural platforms in drug delivery. Translation of these nanometric tools to clinical practice requires deep knowledge of their pharmacokinetic properties and ...
María Isabel González, Pilar Martín-Duque, Manuel Desco, Beatriz Salinas   +3 more
doaj   +1 more source

Genetically Modified Mesenchymal Stromal/Stem Cells as a Delivery Platform for SE-33, a Cathelicidin LL-37 Analogue: Preclinical Pharmacokinetics and Tissue Distribution in C57BL/6 Mice

Antibiotics
Background: The genetic modification of mesenchymal stromal/stem cells (MSCs) to express antimicrobial peptides may provide a promising strategy for developing advanced cell-based therapies for bacterial infections, including those caused or complicated ...
Vagif Ali oglu Gasanov, Dmitry Alexandrovich Kashirskikh, Victoria Alexandrovna Khotina, Arthur Anatolievich Lee, Sofya Yurievna Nikitochkina, Daria Mikhailovna Kuzmina, Irina Vasilievna Mukhina, Ekaterina Andreevna Vorotelyak, Andrey Valentinovich Vasiliev   +8 more
doaj   +1 more source

Longitudinal in vivo biodistribution of nano and micro sized hydroxyapatite particles implanted in a bone defect

Frontiers in Bioengineering and Biotechnology, 2022
Hydroxyapatite (HA) has been widely used as a bone substitute and more recently as a carrier for local delivery of bone targeted drugs. Majority of the approved HA based biomaterials and drug carriers comprise of micrometer sized particulate HA (mHA) or ...
Yang Liu, Sujeesh Sebastian, Jintian Huang, Tova Corbascio, Jacob Engellau, Lars Lidgren, Magnus Tägil, Deepak Bushan Raina   +7 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

The impact of aggregation on the biodistribution of hypericin

International Journal of Oncology, 2006
Hypericin is a potent agent in the photodynamic therapy of cancers and accumulates to a large extent in tumor tissue. To better understand the impact of hypericin aggregates present in the delivery vehicle on the biodistribution of the compound, we compared the in vivo tissue accumulation after administering hypericin suspended as coarse aggregates in ...
Marie, Van De Putte, Tania, Roskams, Guy, Bormans, Alfons, Verbruggen, Peter A M, De Witte   +4 more
openaire   +3 more sources

Characterization of 111In3+ complexes of DTPA amide derivatives: biodistribution and clearance studied by gamma imaging [PDF]

, 2000
A large series of structurally related diethylenetriaminepentaacetic acid amide derivatives with different structures and lipophilic properties were synthesized and radiolabeled with 111In3+.
Prata, M. I. M., Santos, A. C., Prata, M.I.M., Santos, A.C., Lima, J. J. P. de, Chowdhury, A. H. M. S., Geraldes, C.F.G.C., Chowdhury, A.H.M.S., de Lima, J.J.P., Geraldes, C. F. G. C., Bligh, S.W.A., Bligh, S. W. A.   +11 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source