Results 41 to 50 of about 97,326 (260)

Gadolinium Complex with Tris-Hydroxypyridinone as an Input for New Imaging Probes: Thermodynamic Stability, Molecular Modeling and Biodistribution

Molecules
The development of gadolinium-based magnetic resonance imaging (MRI) contrast agents (CAs) is a highly challenging and demanding research field in metal-coordination medicinal chemistry.
Inês Dias, Lurdes Gano, Sílvia Chaves, M. Amélia Santos   +3 more
doaj   +1 more source

Experimental models using radionuclides for assessment of the effects of natural drugs

Brazilian Archives of Biology and Technology, 2008
The aim of this study was to evaluate the effect of the extracts of Nectandra membranacea (N. membranacea), Ginkgo biloba (EGb) and Passiflora (PEF) on the morphology of red blood cells (RBC), on the biodistribution of sodium pertechnetate (99mTcO4Na ...
Silvana Ramos Farias Moreno, Jorge José de Carvalho, Bernardo Rebello, Emely Kazan Rocha, Margareth de Oliveira Timóteo, Beni Olej, Mário Bernardo Filho, Luiz Querino de Araújo Caldas   +7 more
doaj   +1 more source

Characterization of the Biodistribution of a Silica Vesicle Nanovaccine Carrying a Rhipicephalus (Boophilus) microplus Protective Antigen With in vivo Live Animal Imaging

Frontiers in Bioengineering and Biotechnology, 2021
Development of veterinary subunit vaccines comes with a spectrum of challenges, such as the choice of adjuvant, antigen delivery vehicle, and optimization of dosing strategy.
Karishma T. Mody, Bing Zhang, Xun Li, Nicholas L. Fletcher, Dewan T. Akhter, Sandy Jarrett, Jun Zhang, Chengzhong Yu, Kristofer J. Thurecht, Timothy J. Mahony, Neena Mitter   +10 more
doaj   +1 more source

Typical biodistribution.

, 2016
Typical biodistribution 20 h after injection (anterior and posterior gamma camera images) of patient one. The salivary glands, kidneys and tumor lesions show highest uptake. Two bone lesions were analyzed.
Mostafa Shahinfar (3111714), Gerhard Glatting (654539), Christiane Schuchardt (3111711), Harshad R. Kulkarni (3111708), Aviral Singh (3111705), Richard P. Baum (2204560), Ambros J. Beer (560392), Peter Kletting (745284)   +7 more
core   +1 more source

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

Electrostatic properties of human germlines and biodistribution of small biologics

mAbs
Off-target biodistribution of biologics bears important toxicological consequences. Antibody fragments intended for use as vectors of cytotoxic payloads (e.g.
Leticia Maria De Souza Cordeiro, Kelley Christine Atkinson, Argin Aivazian, Patrick Frank Joyce, Fang Jia, Alessandro Mascioni   +5 more
doaj   +1 more source

Enhancement of antifungal activity and transdermal delivery of 5-flucytosine via tailored spanlastic nanovesicles: statistical optimization, in-vitro characterization, and in-vivo biodistribution study

Frontiers in Pharmacology, 2023
Aim and background: This current study aimed to load 5-flucytosine (5-FCY) into spanlastic nanovesicles (SPLNs) to make the drug more efficient as an antifungal and also to load the 5-FCY into a hydrogel that would allow for enhanced transdermal ...
Awaji Y. Safhi, Nimbagal Raghavendra Naveen, Krishna Jayanth Rolla, Penmetsa Durga Bhavani, Mallesh Kurakula, Khaled M. Hosny, Walaa A. Abualsunun, Mohammed Alissa, Abdullah Alsalhi, Amerh Aiad Alahmadi, Khalid Zoghebi, Abdulrahman Sindam Halwaani, Rasha Ibrahim K   +12 more
doaj   +1 more source

Selenium‐Integrated Cyanine Dye With Enhanced Photophysical Properties for Optoacoustic‐Guided Cancer Imaging and Therapy

Advanced Functional Materials, EarlyView.
This study introduces selenium‐integrated cyanine dye (Se‐Cyn), with superior photostability, absorption, and photothermal efficiency, outperforming ICG in NIR window. Its nanoparticle form remains stable in water, accumulates in tumors, and enables strong optoacoustic imaging and effective phototherapy outcomes.
Divyesh Shelar, Snehal Salunkhe, Tony Fröhlich, Uwe Klemm, Pia Anzenhofer, Birgit Rathkolb, Martin Hrabě de Angelis, Oliver Plettenburg, Michael Sattler, Sudesh T. Manjare, Vipul Gujrati, Vasilis Ntziachristos   +11 more
wiley   +1 more source

Lymphatic Biodistribution of Polylactide Nanoparticles

, 2010
Tumor metastases occur through both the cardiovascular and lymphatic circulations. However, the majority of nanoparticle biodistribution studies have been focused on the cardiovascular circulation.
Eric J. Chaney, Rong Tong, Li Tang, Jianjun Cheng, Stephen A. Boppart   +4 more
core   +2 more sources

^99mTc-Labeled Iron Oxide Nanoparticles as Dual-Modality Contrast Agent: A Preliminary Study from Synthesis to Magnetic Resonance and Gamma-Camera Imaging in Mice Models

Nanomaterials, 2022
The combination of two imaging modalities in a single agent has received increasing attention during the last few years, since its synergistic action guarantees both accurate and timely diagnosis.
Maria-Argyro Karageorgou, Aristotelis-Nikolaos Rapsomanikis, Marija Mirković, Sanja Vranješ-Ðurić, Efstathios Stiliaris, Penelope Bouziotis, Dimosthenis Stamopoulos   +6 more
doaj   +1 more source