Results 21 to 30 of about 92,303 (298)

Synthesis, radiolabeling, and evaluation of a (4-quinolinoyl)glycyl-2-cyanopyrrolidine analogue for fibroblast activation protein (FAP) PET imaging

Frontiers in Bioengineering and Biotechnology, 2023
Fibroblast activation protein (FAP) is regarded as a promising target for the diagnosis and treatment of tumors as it was overexpressed in cancer-associated fibroblasts.
Ni Zhang, Ni Zhang, Fei Pan, Lili Pan, Wei Diao, Feijing Su, Rui Huang, Bo Yang, Bo Yang, Yunchun Li, Zhongzhi Qi, Wenjie Zhang, Xiaoai Wu   +12 more
doaj   +1 more source

‘Spikeopathy’: COVID-19 Spike Protein Is Pathogenic, from Both Virus and Vaccine mRNA

Biomedicines, 2023
The COVID-19 pandemic caused much illness, many deaths, and profound disruption to society. The production of ‘safe and effective’ vaccines was a key public health target.
Peter I. Parry, Astrid Lefringhausen, Conny Turni, Christopher J. Neil, Robyn Cosford, Nicholas J. Hudson, Julian Gillespie   +6 more
doaj   +1 more source

Impact of DOTA Conjugation on Pharmacokinetics and Immunoreactivity of [¹⁷⁷Lu]Lu-1C1m-Fc, an Anti TEM-1 Fusion Protein Antibody in a TEM-1 Positive Tumor Mouse Model

Pharmaceutics, 2021
1C1m-Fc, an anti-tumor endothelial marker 1 (TEM-1) scFv-Fc fusion protein antibody, was previously successfully radiolabeled with 177Lu. TEM-1 specific tumor uptake was observed together with a non-saturation dependent liver uptake that could be related
Judith Anna Delage, Alain Faivre-Chauvet, Jacques Barbet, Julie Katrin Fierle, Niklaus Schaefer, George Coukos, David Viertl, Steven Mark Dunn, Silvano Gnesin, John O. Prior   +9 more
doaj   +1 more source

Unraveling the In Vivo Protein Corona

Cells, 2021
Understanding the behavior of nanoparticles upon contact with a physiological environment is of urgent need in order to improve their properties for a successful therapeutic application.
Johanna Simon, Gabor Kuhn, Michael Fichter, Stephan Gehring, Katharina Landfester, Volker Mailänder   +5 more
doaj   +1 more source

Visualization of cardiac uptake of bone marrow mesenchymal stem cell‐derived extracellular vesicles after intramyocardial or intravenous injection in murine myocardial infarction

Physiological Reports, 2023
In animal models, human bone marrow mesenchymal stem cell‐derived extracellular vesicles (MSC‐EV) have been found to have beneficial effects in cardiovascular disease, but only when administered via intramyocardial injection.
Cynthia M. Xu, Sharif A. Sabe, Rayane Brinck‐Teixeira, Mohamed Sabra, Frank W. Sellke, M. Ruhul Abid   +5 more
doaj   +1 more source

Assessment of the biocompatibility and biodistribution of fluorescent oleic acid capped ZnSe/CdS/ core shell quantum dots after intravenous injection in Balb/c mice [PDF]

BioImpacts
Introduction: Quantum dots (QDs) are semiconductor nanocrystals with inherent fluorescence having several advantages over traditional fluorescent probes including their small size (5–10 nm), tunable excitation and emission spectra, ease of surface ...
Aakriti Tyagi, Disha Mittal, S. Bhanoth, Ankita Leekha, Anita K. Verma   +4 more
doaj   +1 more source

Biodistribution and cell-type affinity of myotropic extracellular vesicle candidates

, 2023
Lennon, Shannon L.Muscular pathologies represent a class of diseases and disorders comprising both inherited genetic disorders (i.e. muscular dystrophies) and secondary conditions (i.e. cachexia).
Shuler, Kyle
core   +1 more source

The Impact of Polymer Size and Cleavability on the Intravenous Pharmacokinetics of PEG-Based Hyperbranched Polymers in Rats

Nanomaterials, 2020
A better understanding of the impact of molecular size and linkers is important for PEG-based hyperbranched polymers (HBPs) intended as tailored drug delivery vehicles.
Nirmal Marasini, Changkui Fu, Nicholas L. Fletcher, Christopher Subasic, Gerald Er, Karine Mardon, Kristofer J. Thurecht, Andrew K. Whittaker, Lisa M. Kaminskas   +8 more
doaj   +1 more source

Multiphysics pharmacokinetic model for targeted nanoparticles

Frontiers in Medical Technology, 2022
Nanoparticles (NP) are being increasingly explored as vehicles for targeted drug delivery because they can overcome free therapeutic limitations by drug encapsulation, thereby increasing solubility and transport across cell membranes.
Emma M. Glass, Emma M. Glass, Sahil Kulkarni, Christina Eng, Shurui Feng, Avishi Malaviya, Ravi Radhakrishnan, Ravi Radhakrishnan   +7 more
doaj   +1 more source

Biodistribution of therapeutic extracellular vesicles

Extracellular Vesicles and Circulating Nucleic Acids, 2023
The field of extracellular vesicles (EVs) has seen a tremendous paradigm shift in the past two decades, from being regarded as cellular waste bags to being considered essential mediators in intercellular communication. Their unique ability to transfer macromolecules across cells and biological barriers has made them a rising star in drug delivery ...
Gupta, D, Wiklander, OPB, Wood, MJA, El-Andaloussi, S   +3 more
openaire   +3 more sources