Results 21 to 30 of about 85,054 (209)

Monitoring dexamethasone skin biodistribution with ex vivo MALDI-TOF mass spectrometry imaging and confocal Raman microscopy [PDF]

, 2023
Two of the most promising techniques in terms of ex vivo skin imaging and quantifying are confocal Raman microscopy and MALDI-TOF mass spectrometry imaging (MALDI-TOF MSI).
Otero-Espinar, Francisco J., García Berrocoso, Teresa, Vázquez Fernández, Ezequiel, Fernández-Campos, Francisco, Otero Espinar, Francisco J., Pena Rodríguez, Eloy, Pena-Rodríguez, Eloy, Abian Moñux, Joaquín, Abian, Joaquin, Otero Espinar, Francisco Javier, García-Berrocoso, Teresa, Fernández Campos, Francisco   +11 more
core   +1 more source

Optimization in Chemical Modification of Single-Stranded siRNA Encapsulated by Neutral Cytidinyl/Cationic Lipids

Frontiers in Chemistry, 2022
Single-stranded siRNA (ss-siRNA) refers to the antisense strand of siRNA, which plays the role of gene silencing. Since single-stranded RNA is unstable, the present study employed a homemade neutral cytidinyl/cationic lipid delivery system and chemical ...
Zheng Li, Xixian Wang, Xinyang Zhou, Jie Wang, Zhu Guan, Zhenjun Yang   +5 more
doaj   +1 more source

Development of whole body scanning PCR, a highly sensitive method to study the biodistribution of mRNAs, noncoding RNAs and therapeutic oligonucleotides [PDF]

, 2015
Based on RNA interference (RNAi), a mechanism regulating gene expression at the post-transcriptional level in eukaryotes, therapeutic siRNAs are slowly moving towards late phase clinical trials.
Boos, Julien Alfred Jean-Paul
core   +1 more source

Exosomes: Biological Pharmaceutical Nanovectors for Theranostics

Frontiers in Bioengineering and Biotechnology, 2022
Exosomes are natural cell-derived nanovesicles of endocytic origin that enable cellular crosstalk by transferring encapsulated molecular cargos across biological barriers, thereby holding significantly complex implications in the etiology and progression
Shindu C. Thomas, Jin-Woo Kim, Giovanni M. Pauletti, Daniel J. Hassett, Nalinikanth Kotagiri   +4 more
doaj   +1 more source

Biodistribution of VSX-1.

, 2023
(A) In vivo imaging of VSX-1’s biodistribution. Labeled VSX (the antibody alone) or VSX-1 (the ADC) was administered to animals IP and monitored by imaging up until 48 hours post-injection (h.p.i.). Both agents distributed throughout the animal (i.e.
Kenneth Johnson (830129), Bradley L. Pentelute (1247046), Faycal Touti (16949388), Zachary Shriver (228536), Surin Mong (16949382), Hamid Tissire (16949385), Jennifer Varin-Simon (6010544), Gregory J. Babcock (16949391), Andrew Wollacott (9547789), Karthik Viswanathan (182754), David Skurnik (454610), Obadiah Plante (9547792), James C. Delaney (551875), Thomas Guillard (296088), Fany Reffuveille (567572), Kai Li (205203), Eric Frapy (89685)   +16 more
core   +1 more source

A Novel Glycyrrhetinic Acid-Modified Oxaliplatin Liposome for Liver-Targeting and in vitro/vivo Evaluation [Retraction]

Drug Design, Development and Therapy, 2022
Chen J, Jiang H, Wu Y, Li Y, Gao Y. Drug Des Devel Ther. 2015;9:2265–2275. The Editor and Publisher of Drug Design, Development and Therapy wish to retract the published article.
Chen J, Jiang H, Wu Y, Li Y, Gao Y
doaj  

Cellular biodistribution of polymeric nanoparticles in the immune system

, 2017
The biodistribution of polymeric nanoparticles (NPs) is of crucial importance in the development of nanoparticle-based vaccine delivery or immunotherapy for cancer.
楊雅雯, Yang, Ya-Wun;Luo, Wen-Hui
core   +1 more source

Characterization of 111In3+ complexes of DTPA amide derivatives: biodistribution and clearance studied by gamma imaging [PDF]

, 2000
A large series of structurally related diethylenetriaminepentaacetic acid amide derivatives with different structures and lipophilic properties were synthesized and radiolabeled with 111In3+.
Prata, M. I. M., Santos, A. C., Prata, M.I.M., Santos, A.C., Lima, J. J. P. de, Chowdhury, A. H. M. S., Geraldes, C.F.G.C., Chowdhury, A.H.M.S., de Lima, J.J.P., Geraldes, C. F. G. C., Bligh, S.W.A., Bligh, S. W. A.   +11 more
core   +1 more source

Considerations in biodistribution evaluation of iPSC-derived cell therapy: A pancreatic islet cell case study

Molecular Therapy: Methods & Clinical Development
Induced pluripotent stem cells (iPSCs) have substantial transformative potential in regenerative medicine, enabling tissue repair and restoration.
Miyu Nakayama, Yuu Moriya, Hikaru Ueno, Takeshi Watanabe, Hideki Hirabayashi, Syunsuke Yamamoto   +5 more
doaj   +1 more source

Mixed Amphiphilic Polymeric Nanoparticles of Chitosan, Poly(vinyl alcohol) and Poly(methyl methacrylate) for Intranasal Drug Delivery: A Preliminary In Vivo Study

Molecules, 2020
Intranasal (i.n.) administration became an alternative strategy to bypass the blood–brain barrier and improve drug bioavailability in the brain. The main goal of this work was to preliminarily study the biodistribution of mixed amphiphilic mucoadhesive ...
Inbar Schlachet, Hen Moshe Halamish, Alejandro Sosnik   +2 more
doaj   +1 more source