Results 21 to 30 of about 97,326 (260)

Considerations in biodistribution evaluation of iPSC-derived cell therapy: A pancreatic islet cell case study

Molecular Therapy: Methods & Clinical Development
Induced pluripotent stem cells (iPSCs) have substantial transformative potential in regenerative medicine, enabling tissue repair and restoration.
Miyu Nakayama, Yuu Moriya, Hikaru Ueno, Takeshi Watanabe, Hideki Hirabayashi, Syunsuke Yamamoto   +5 more
doaj   +1 more source

Mixed Amphiphilic Polymeric Nanoparticles of Chitosan, Poly(vinyl alcohol) and Poly(methyl methacrylate) for Intranasal Drug Delivery: A Preliminary In Vivo Study

Molecules, 2020
Intranasal (i.n.) administration became an alternative strategy to bypass the blood–brain barrier and improve drug bioavailability in the brain. The main goal of this work was to preliminarily study the biodistribution of mixed amphiphilic mucoadhesive ...
Inbar Schlachet, Hen Moshe Halamish, Alejandro Sosnik   +2 more
doaj   +1 more source

Safety Evaluations of Rapamycin Perfluorocarbon Nanoparticles in Ovarian Tumor-Bearing Mice

Nanomaterials
Nanomedicine holds great potential for revolutionizing medical treatment. Ongoing research and advancements in nanotechnology are continuously expanding the possibilities, promising significant advancements in healthcare.
Qingyu Zhou, John C. Harding, Ping Fan, Ivan Spasojevic, Attila Kovacs, Antonina Akk, Adam Mitchell, Luke E. Springer, Joseph P. Gaut, Daniel A. Rauch, Samuel A. Wickline, Christine T. N. Pham, Katherine Fuh, Hua Pan   +13 more
doaj   +1 more source

Fluorescent Dye Labeling Changes the Biodistribution of Tumor-Targeted Nanoparticles

Pharmaceutics, 2020
Fluorescent dye labeling is a common strategy to analyze the fate of administered nanoparticles in living organisms. However, to which extent the labeling processes can alter the original nanoparticle biodistribution has been so far neglected.
Patricia Álamo, Victor Pallarès, María Virtudes Céspedes, Aïda Falgàs, Julieta M. Sanchez, Naroa Serna, Laura Sánchez-García, Eric Voltà-Duràn, Gordon A. Morris, Alejandro Sánchez-Chardi, Isolda Casanova, Ramón Mangues, Esther Vazquez, Antonio Villaverde, Ugutz Unzueta   +14 more
doaj   +1 more source

Distribution and metabolism of iPSC-MSCs in the joint cavity of an osteoarthritis rat model

Frontiers in Bioengineering and Biotechnology
IntroductionTo investigate the metabolism and distribution of iPSC‐MSCs in the joint cavity of rats with knee osteoarthritis (KOA).MethodsThe iPSC‐MSCs labeled with the Antares2 luciferase gene were injected into the knee joints of rats, and then the ...
Xiaoyang Yuan, Xulei Wang, Xulei Wang, Tianxi Du, Feng Zhang, Gang Cheng, Kang Wang, Haochen Xu, Pingting Yang, Yan Chang, Wei Wei, Peng He, Shangxue Yan, Shangxue Yan   +13 more
doaj   +1 more source

Radioactive Labeling of Milk-Derived Exosomes with ^99mTc and In Vivo Tracking by SPECT Imaging

Nanomaterials, 2020
Over the last decade, exosomes from diverse biological sources have been proposed as new natural platforms in drug delivery. Translation of these nanometric tools to clinical practice requires deep knowledge of their pharmacokinetic properties and ...
María Isabel González, Pilar Martín-Duque, Manuel Desco, Beatriz Salinas   +3 more
doaj   +1 more source

Genetically Modified Mesenchymal Stromal/Stem Cells as a Delivery Platform for SE-33, a Cathelicidin LL-37 Analogue: Preclinical Pharmacokinetics and Tissue Distribution in C57BL/6 Mice

Antibiotics
Background: The genetic modification of mesenchymal stromal/stem cells (MSCs) to express antimicrobial peptides may provide a promising strategy for developing advanced cell-based therapies for bacterial infections, including those caused or complicated ...
Vagif Ali oglu Gasanov, Dmitry Alexandrovich Kashirskikh, Victoria Alexandrovna Khotina, Arthur Anatolievich Lee, Sofya Yurievna Nikitochkina, Daria Mikhailovna Kuzmina, Irina Vasilievna Mukhina, Ekaterina Andreevna Vorotelyak, Andrey Valentinovich Vasiliev   +8 more
doaj   +1 more source

Longitudinal in vivo biodistribution of nano and micro sized hydroxyapatite particles implanted in a bone defect

Frontiers in Bioengineering and Biotechnology, 2022
Hydroxyapatite (HA) has been widely used as a bone substitute and more recently as a carrier for local delivery of bone targeted drugs. Majority of the approved HA based biomaterials and drug carriers comprise of micrometer sized particulate HA (mHA) or ...
Yang Liu, Sujeesh Sebastian, Jintian Huang, Tova Corbascio, Jacob Engellau, Lars Lidgren, Magnus Tägil, Deepak Bushan Raina   +7 more
doaj   +1 more source

Hig biodistribution and amyloid∶organ ratio.

, 2013
Hig biodistribution and amyloid∶organ ratio.
Ying Huang (53474), Sallie Macy (292365), Angela Williams (292362), Jonathan S. Wall (287997), Dale Schenk (222959), Stephen J. Kennel (288001), Tina Richey (292363), Alan Stuckey (292364), Robert Donnell (292366), Peter Seubert (222943), Robin Barbour (222950)   +10 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source