Toxicology and Biodistribution: The Clinical Value of Animal Biodistribution Studies [PDF]
Molecular Therapy - Methods & Clinical Development, 2018 Since the human genome decoding, understanding and identification of genetic disturbances behind many diseases, including cancer, are intensively increasing. Scientific and technological advances in this area trigger the search for therapeutic (curative) approaches targeting the correction of gene disturbances.
Beatriz Silva Lima +1 more
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Biodistribution of therapeutic extracellular vesicles
Extracellular Vesicles and Circulating Nucleic Acids, 2023 The field of extracellular vesicles (EVs) has seen a tremendous paradigm shift in the past two decades, from being regarded as cellular waste bags to being considered essential mediators in intercellular communication. Their unique ability to transfer macromolecules across cells and biological barriers has made them a rising star in drug delivery ...
Gupta, Dhanu +3 more
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Unraveling the In Vivo Protein Corona
Cells, 2021 Understanding the behavior of nanoparticles upon contact with a physiological environment is of urgent need in order to improve their properties for a successful therapeutic application.
Johanna Simon +5 more
doaj +1 more source
Physiological Reports, 2023 In animal models, human bone marrow mesenchymal stem cell‐derived extracellular vesicles (MSC‐EV) have been found to have beneficial effects in cardiovascular disease, but only when administered via intramyocardial injection.
Cynthia M. Xu +5 more
doaj +1 more source
Assessment of the biocompatibility and biodistribution of fluorescent oleic acid capped ZnSe/CdS/ core shell quantum dots after intravenous injection in Balb/c mice [PDF]
BioImpactsIntroduction: Quantum dots (QDs) are semiconductor nanocrystals with inherent fluorescence having several advantages over traditional fluorescent probes including their small size (5–10 nm), tunable excitation and emission spectra, ease of surface ...
Aakriti Tyagi +4 more
doaj +1 more source
Effect of an extract of Centella asiatica on the biodistribution of sodium pertechnetate (Na99mTcO4) and on the fixation of radioactivity on blood constituents [PDF]
, 2008 This study evaluates the effects of an acute treatment with a Centella asiatica (CA) extract on the biodistribution of the radiopharmaceutical Na99mTcO4 and on the fixation of technetium-99m on blood constituents. Wistar rats were treated with CA extract
Adenilson de Souza da Fonseca +22 more
core +4 more sources
Nanomaterials, 2020 A better understanding of the impact of molecular size and linkers is important for PEG-based hyperbranched polymers (HBPs) intended as tailored drug delivery vehicles.
Nirmal Marasini +8 more
doaj +1 more source
Synthesis, metal complexation and biological evaluation of a novel semi-rigid bifunctional chelating agent for 99mTc labelling [PDF]
, 2006 A novel bifunctional chelating agent bearing an aromatic ring has been synthesised and characterised. This ligand formed well-defined oxorhenium complexes.
Benoist, Eric +4 more
core +2 more sources
Evaluation of a PACAP Peptide Analogue Labeled with (68)Ga Using Two Different Chelating Agents. [PDF]
, 2016 OBJECTIVE: The authors have conjugated chelating agents (DOTA and NODAGA) with a peptide (pituitary adenylate cyclase-activating peptide [PACAP] analogue) that has a high affinity for VPAC1 receptors expressed on cancer cells.
Chen, Chang-Po +6 more
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Lymphatic Biodistribution of Polylactide Nanoparticles [PDF]
Molecular Imaging, 2010 Tumor metastases occur through both the cardiovascular and lymphatic circulations. However, the majority of nanoparticle biodistribution studies have been focused on the cardiovascular circulation. In this study, we report the formulation of Cy5-labeled polylactide (Cy5-PLA) nanoparticles with controlled size and surface features and the subsequent ...
Eric J. Chaney +4 more
openaire +3 more sources