Results 11 to 20 of about 92,303 (298)

Studies on the biodistribution of dextrin nanoparticles [PDF]

Nanotechnology, 2010
The characterization of biodistribution is a central requirement in the development of biomedical applications based on the use of nanoparticles, in particular for controlled drug delivery. The blood circulation time, organ biodistribution and rate of excretion must be well characterized in the process of product development.
Gonçalves, C., Ferreira, M. F. M., Santos, A. C., Prata, M. I. M., Martins, J. A., Geraldes, C. F. G. C., Gama, F. M.   +6 more
openaire   +5 more sources

Lymphatic Biodistribution of Polylactide Nanoparticles [PDF]

Molecular Imaging, 2010
Tumor metastases occur through both the cardiovascular and lymphatic circulations. However, the majority of nanoparticle biodistribution studies have been focused on the cardiovascular circulation. In this study, we report the formulation of Cy5-labeled polylactide (Cy5-PLA) nanoparticles with controlled size and surface features ...
Chaney, Eric J., Tang, Li, Tong, Rong, Cheng, Jianjun, Boppart, Stephen A.   +4 more
core   +5 more sources

Noninvasive Optical Imaging of Nanomedicine Biodistribution [PDF]

ACS Nano, 2012
Nanomedicines are sub-micrometer-sized carrier materials designed to improve the biodistribution of i.v. administered (chemo-) therapeutic agents. In recent years, ever more efforts in the nanomedicine field have employed optical imaging (OI) techniques to monitor biodistribution and target site accumulation.
Sijumon Kunjachan, Felix Gremse, Benjamin Theek, Patrick Koczera, Robert Pola, Michal Pechar, Tomas Etrych, Karel Ulbrich, Gert Storm, Fabian Kiessling, Twan Lammers   +10 more
openaire   +5 more sources

The Development and Evaluation of Novel Reagents for Pre-Targeted Radioimmunotherapy [PDF]

, 2004
PhDIn a pretargeting radioimmunotherapy system, monoclonal antibodies (MAbs) derivatised with a high affinity streptavidin receptor are used in a localisation step.
Hainsworth, James Edward Scott
core   +4 more sources

In vivo targeting capacities of different nanoparticles to prostate tissues based on a mouse model of chronic bacterial prostatitis

Frontiers in Bioengineering and Biotechnology, 2022
Chronic bacterial prostatitis usually occurs in men and seriously affects the quality of life of patients. The efficacy of chronic bacterial prostatitis treatment is limited by the difficulty for free drugs (e.g., antibiotics) to penetrate the prostate ...
Ruimin Hu, Yang Yang, Guojing Song, Fuhan Zhao, Saipeng Chen, Zhansong Zhou, Jun Zheng, Wenhao Shen   +7 more
doaj   +1 more source

ROCKETS – a novel one-for-all toolbox for light sheet microscopy in drug discovery

Frontiers in Immunology, 2023
Advancing novel immunotherapy strategies requires refined tools in preclinical research to thoroughly assess drug targets, biodistribution, safety, and efficacy.
Joerg P. J. Mueller, Joerg P. J. Mueller, Michael Dobosz, Nils O’Brien, Nassri Abdoush, Anna Maria Giusti, Martin Lechmann, Franz Osl, Ann-Katrin Wolf, Ann-Katrin Wolf, Estibaliz Arellano-Viera, Haroon Shaikh, Markus Sauer, Andreas Rosenwald, Frank Herting, Pablo Umaña, Sara Colombetti, Thomas Pöschinger, Andreas Beilhack   +18 more
doaj   +1 more source

A physiologically based pharmacokinetic model for V937 oncolytic virus in mice

Frontiers in Pharmacology, 2023
Introduction: Oncolytic viruses (OVs) represent a novel therapeutic strategy in oncology due to their capability to selectively infect and replicate in cancer cells, triggering a direct and/or immune-induced tumor lysis. However, the mechanisms governing
Sara Peribañez-Dominguez, Sara Peribañez-Dominguez, Zinnia P. Parra-Guillen, Zinnia P. Parra-Guillen, Tomoko Freshwater, Iñaki F. Troconiz, Iñaki F. Troconiz, Iñaki F. Troconiz   +7 more
doaj   +1 more source

Synthesis, In Vitro Testing, and Biodistribution of Surfactant-Free Radioactive Nanoparticles for Cancer Treatment

Nanomaterials, 2022
New forms of cancer treatment, which are effective, have simple manufacturing processes, and easily transportable, are of the utmost necessity. In this work, a methodology for the synthesis of radioactive Gold-198 nanoparticles without the use of ...
Carla Daruich de Souza, Angelica Bueno Barbezan, Wilmmer Alexander Arcos Rosero, Sofia Nascimento dos Santos, Diego Vergaças de Sousa Carvalho, Carlos Alberto Zeituni, Emerson Soares Bernardes, Daniel Perez Vieira, Patrick Jack Spencer, Martha Simões Ribeiro, Maria Elisa Chuery Martins Rostelato   +10 more
doaj   +1 more source

Biogenic Silver Nanoparticles: What We Know and What Do We Need to Know?

Nanomaterials, 2021
Nanobiotechnology is considered to be one of the fastest emerging fields. It is still a relatively new and exciting area of research with considerable potential for development.
Mahendra Rai, Avinash P. Ingle, Joanna Trzcińska-Wencel, Magdalena Wypij, Shital Bonde, Alka Yadav, Gabriela Kratošová, Patrycja Golińska   +7 more
doaj   +1 more source

Renal Artery Catheterization for Microcapsules’ Targeted Delivery to the Mouse Kidney

Pharmaceutics, 2022
The problem of reducing the side effects associated with drug distribution throughout the body in the treatment of various kidney diseases can be solved by effective targeted drug delivery.
Olga I. Gusliakova, Ekaterina S. Prikhozhdenko, Valentina O. Plastun, Oksana A. Mayorova, Natalia A. Shushunova, Arkady S. Abdurashitov, Oleg A. Kulikov, Maxim A. Abakumov, Dmitry A. Gorin, Gleb B. Sukhorukov, Olga A. Sindeeva   +10 more
doaj   +1 more source