Results 31 to 40 of about 85,054 (209)

Safety Evaluations of Rapamycin Perfluorocarbon Nanoparticles in Ovarian Tumor-Bearing Mice

Nanomaterials
Nanomedicine holds great potential for revolutionizing medical treatment. Ongoing research and advancements in nanotechnology are continuously expanding the possibilities, promising significant advancements in healthcare.
Qingyu Zhou, John C. Harding, Ping Fan, Ivan Spasojevic, Attila Kovacs, Antonina Akk, Adam Mitchell, Luke E. Springer, Joseph P. Gaut, Daniel A. Rauch, Samuel A. Wickline, Christine T. N. Pham, Katherine Fuh, Hua Pan   +13 more
doaj   +1 more source

Fluorescent Dye Labeling Changes the Biodistribution of Tumor-Targeted Nanoparticles

Pharmaceutics, 2020
Fluorescent dye labeling is a common strategy to analyze the fate of administered nanoparticles in living organisms. However, to which extent the labeling processes can alter the original nanoparticle biodistribution has been so far neglected.
Patricia Álamo, Victor Pallarès, María Virtudes Céspedes, Aïda Falgàs, Julieta M. Sanchez, Naroa Serna, Laura Sánchez-García, Eric Voltà-Duràn, Gordon A. Morris, Alejandro Sánchez-Chardi, Isolda Casanova, Ramón Mangues, Esther Vazquez, Antonio Villaverde, Ugutz Unzueta   +14 more
doaj   +1 more source

Pharmacokinetics and Biodistribution of Eriocitrin in Rats

Journal of Agricultural and Food Chemistry, 2021
Eriocitrin plays a role in the reduction of oxidative stress and inflammation linked to the development of diabetes mellitus and atherosclerosis. We investigated the pharmacokinetics and distribution of eriocitrin metabolites in rats orally administered with eriocitrin. Plasma, urine, and organs were collected at 12 different time points from 0 to 24 h
Paula S. Ferreira, John A. Manthey, Marina S. Nery, Thais B. Cesar   +3 more
openaire   +3 more sources

Distribution and metabolism of iPSC-MSCs in the joint cavity of an osteoarthritis rat model

Frontiers in Bioengineering and Biotechnology
IntroductionTo investigate the metabolism and distribution of iPSC‐MSCs in the joint cavity of rats with knee osteoarthritis (KOA).MethodsThe iPSC‐MSCs labeled with the Antares2 luciferase gene were injected into the knee joints of rats, and then the ...
Xiaoyang Yuan, Xulei Wang, Xulei Wang, Tianxi Du, Feng Zhang, Gang Cheng, Kang Wang, Haochen Xu, Pingting Yang, Yan Chang, Wei Wei, Peng He, Shangxue Yan, Shangxue Yan   +13 more
doaj   +1 more source

Radioactive Labeling of Milk-Derived Exosomes with ^99mTc and In Vivo Tracking by SPECT Imaging

Nanomaterials, 2020
Over the last decade, exosomes from diverse biological sources have been proposed as new natural platforms in drug delivery. Translation of these nanometric tools to clinical practice requires deep knowledge of their pharmacokinetic properties and ...
María Isabel González, Pilar Martín-Duque, Manuel Desco, Beatriz Salinas   +3 more
doaj   +1 more source

Genetically Modified Mesenchymal Stromal/Stem Cells as a Delivery Platform for SE-33, a Cathelicidin LL-37 Analogue: Preclinical Pharmacokinetics and Tissue Distribution in C57BL/6 Mice

Antibiotics
Background: The genetic modification of mesenchymal stromal/stem cells (MSCs) to express antimicrobial peptides may provide a promising strategy for developing advanced cell-based therapies for bacterial infections, including those caused or complicated ...
Vagif Ali oglu Gasanov, Dmitry Alexandrovich Kashirskikh, Victoria Alexandrovna Khotina, Arthur Anatolievich Lee, Sofya Yurievna Nikitochkina, Daria Mikhailovna Kuzmina, Irina Vasilievna Mukhina, Ekaterina Andreevna Vorotelyak, Andrey Valentinovich Vasiliev   +8 more
doaj   +1 more source

Longitudinal in vivo biodistribution of nano and micro sized hydroxyapatite particles implanted in a bone defect

Frontiers in Bioengineering and Biotechnology, 2022
Hydroxyapatite (HA) has been widely used as a bone substitute and more recently as a carrier for local delivery of bone targeted drugs. Majority of the approved HA based biomaterials and drug carriers comprise of micrometer sized particulate HA (mHA) or ...
Yang Liu, Sujeesh Sebastian, Jintian Huang, Tova Corbascio, Jacob Engellau, Lars Lidgren, Magnus Tägil, Deepak Bushan Raina   +7 more
doaj   +1 more source

Effect of obesity on biodistribution of nanoparticles [PDF]

Journal of Controlled Release, 2018
Nanoparticles have specific features (lipophilicity, surface charge, composition and size). Studies regarding the biological behavior of nanoparticles in diseases such diabetics and obesity are scarce. Here, we evaluated two nanoparticles: magnetic core mesoporous silica (MSN) (58 nm) and polycaprolactone (PCL) nanoparticle (280 nm) in obese mice ...
Claudiana de Jesus Felismino, Edward Helal-Neto, Filipe Leal Portilho, Suyene Rocha Pinto, Félix Sancenón, Ramón Martínez-Máñez, Agatha de Assis Ferreira, Simone Vargas da Silva, Thereza Christina Barja-Fidalgo, Ralph Santos-Oliveira   +9 more
openaire   +4 more sources

The impact of aggregation on the biodistribution of hypericin

International Journal of Oncology, 2006
Hypericin is a potent agent in the photodynamic therapy of cancers and accumulates to a large extent in tumor tissue. To better understand the impact of hypericin aggregates present in the delivery vehicle on the biodistribution of the compound, we compared the in vivo tissue accumulation after administering hypericin suspended as coarse aggregates in ...
Marie, Van De Putte, Tania, Roskams, Guy, Bormans, Alfons, Verbruggen, Peter A M, De Witte   +4 more
openaire   +3 more sources

A comparative biodistribution study of polymeric and lipid-based nanoparticles. [PDF]

, 2022
Biodistribution of nanoencapsulated bioactive compounds is primarily determined by the size, shape, chemical composition and surface properties of the encapsulating nanoparticle, and, thus, less dependent on the physicochemical properties of the active ...
Jong, Wim H. De, Delmaar, Christiaan, Hyldbakk, Astrid, Åslund, Andreas K. O., de Jong, Wim H., Åslund, Andreas K O, Åslund, Andreas, Snipstad, Sofie, Borgos, Sven Even F, Vandebriel, Rob J., Vandebriel, Rob J, Vernstad, Kai, de Jong, Wim H, Texier, Isabelle, Schmid, Ruth Baumberger, Schmid, Ruth, Borgos, Sven Even F., Rustique, Emilie, Caputo, Fanny   +18 more
core   +1 more source