Results 31 to 40 of about 92,303 (298)
Frontiers in Chemistry, 2022 Single-stranded siRNA (ss-siRNA) refers to the antisense strand of siRNA, which plays the role of gene silencing. Since single-stranded RNA is unstable, the present study employed a homemade neutral cytidinyl/cationic lipid delivery system and chemical ...
Zheng Li +5 more
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Development of whole body scanning PCR, a highly sensitive method to study the biodistribution of mRNAs, noncoding RNAs and therapeutic oligonucleotides [PDF]
, 2015 Based on RNA interference (RNAi), a mechanism regulating gene expression at the post-transcriptional level in eukaryotes, therapeutic siRNAs are slowly moving towards late phase clinical trials.
Boos, Julien Alfred Jean-Paul
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Exosomes: Biological Pharmaceutical Nanovectors for Theranostics
Frontiers in Bioengineering and Biotechnology, 2022 Exosomes are natural cell-derived nanovesicles of endocytic origin that enable cellular crosstalk by transferring encapsulated molecular cargos across biological barriers, thereby holding significantly complex implications in the etiology and progression
Shindu C. Thomas +4 more
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Pharmacokinetics and Biodistribution of Eriocitrin in Rats
Journal of Agricultural and Food Chemistry, 2021 Eriocitrin plays a role in the reduction of oxidative stress and inflammation linked to the development of diabetes mellitus and atherosclerosis. We investigated the pharmacokinetics and distribution of eriocitrin metabolites in rats orally administered with eriocitrin. Plasma, urine, and organs were collected at 12 different time points from 0 to 24 h
Paula S. Ferreira +3 more
openaire +3 more sources
Drug Design, Development and Therapy, 2022 Chen J, Jiang H, Wu Y, Li Y, Gao Y. Drug Des Devel Ther. 2015;9:2265–2275. The Editor and Publisher of Drug Design, Development and Therapy wish to retract the published article.
Chen J, Jiang H, Wu Y, Li Y, Gao Y
doaj
Cellular biodistribution of polymeric nanoparticles in the immune system
, 2017 The biodistribution of polymeric nanoparticles (NPs) is of crucial importance in the development of nanoparticle-based vaccine delivery or immunotherapy for cancer.
楊雅雯, Yang, Ya-Wun;Luo, Wen-Hui
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Molecular Therapy: Methods & Clinical DevelopmentInduced pluripotent stem cells (iPSCs) have substantial transformative potential in regenerative medicine, enabling tissue repair and restoration.
Miyu Nakayama +5 more
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Molecules, 2020 Intranasal (i.n.) administration became an alternative strategy to bypass the blood–brain barrier and improve drug bioavailability in the brain. The main goal of this work was to preliminarily study the biodistribution of mixed amphiphilic mucoadhesive ...
Inbar Schlachet +2 more
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Safety Evaluations of Rapamycin Perfluorocarbon Nanoparticles in Ovarian Tumor-Bearing Mice
NanomaterialsNanomedicine holds great potential for revolutionizing medical treatment. Ongoing research and advancements in nanotechnology are continuously expanding the possibilities, promising significant advancements in healthcare.
Qingyu Zhou +13 more
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Fluorescent Dye Labeling Changes the Biodistribution of Tumor-Targeted Nanoparticles
Pharmaceutics, 2020 Fluorescent dye labeling is a common strategy to analyze the fate of administered nanoparticles in living organisms. However, to which extent the labeling processes can alter the original nanoparticle biodistribution has been so far neglected.
Patricia Álamo +14 more
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