Results 261 to 270 of about 92,303 (298)

The Biodistribution of Radiocopper-Labeled Compounds

1989
Porphyrins form extremely stable chelates with Cu2+. Two copper radionuclides, 67Cu and 64Cu, have attractive nuclear decay properties for use in nuclear medicine applications. We have investigated the use of radiocopper-labeled porphyrins for localization in inflamed tissue and for attachment to antibodies for tumor imaging and therapy.
J A, Mercer-Smith, D A, Cole, J C, Roberts, D, Lewis, M J, Behr, D K, Lavallee   +5 more
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Scintigraphic visualization of intrathecal liposome biodistribution [PDF]

Acta Anaesthesiologica Scandinavica, 1997
Background: Liposomes containing local anaesthetics have been administered intrathecally and in the epidural space. Poor attention has been given to the pharmacokinetics of liposomes as drug carriers. Therefore, we observed the biodistribution of liposomes after intrathecal injection in rats by scintigraphic imaging during 24 h.Methods: We administered
Umbrain, V, D'Haese, J, Alafandy, M, De Roover, E, Schoutens, A, Van Gansbeke, B, Albert, Adelin, Goffinet, Gerhard, Camu, F, Legros, F J   +9 more
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Bioavailability and biodistribution of nanodelivered lutein

Food Chemistry, 2016
The aim of the study was to evaluate the ability of poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NP) to enhance lutein bioavailability. The bioavailability of free lutein and PLGA-NP lutein in rats was assessed by determining plasma pharmacokinetics and deposition in selected tissues. Lutein uptake and secretion was also assessed in Caco-2 cells.
Alison, Kamil, Donald E, Smith, Jeffrey B, Blumberg, Carlos, Astete, Cristina, Sabliov, C-Y, Oliver Chen   +5 more
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Iatrogenic alterations in radionuclide biodistributions

Seminars in Nuclear Medicine, 1979
The biodistribution of radiotracers used in diagnostic imaging is grossly and recognizably altered by a wide variety of drugs and other treatment modalities, such as surgery and radiotherapy. Knowledge of such altered biodistribution is important both in making diagnostic inferences from scans and in dosimetric considerations.
B C, Lentle, J R, Scott, A A, Noujaim, F I, Jackson   +3 more
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Radiolabeling and biodistribution of amiodarone and desethylamiodarone

Nuclear Medicine and Biology, 1995
The antiarrhythmic drug amiodarone and its metabolite desethylamiodarone, were radiolabeled with sodium [123I]-iodide in > 98% yield using the exchange labeling method. Biodistribution studies with 123I-amiodarone in mice showed high liver and lung uptake.
J C, Bellen, S, Penglis, C, Tsopelas
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Biodistribution and toxicity of gold nanoparticles

Nanotechnologies in Russia, 2011
This paper reviews data on the biodistribution and toxicity of five types of gold nanoparticles (GNPs) (atomic clusters and colloidal particles with diameters of 1 to 200 nm, gold nanorods (GNRs), silica/gold nanoshells (GNSs), hollow GNSs, and nanowires) in in vivo and in vitro experiments.
Lev Dykman, Nikolai Khlebtsov
openaire   +1 more source

Antithrombin III: Biodistribution in Healthy Volunteers

Thrombosis and Haemostasis, 1987
SummaryFive healthy volunteers were injected intravenously with 73-90 uCi purified human 131I-Antithrombin III (AT III), specific biological activity 5.6 U/mg. The tracer data were analysed using a three compartment model. The plasma radioactivity half life was 66.2 ± 1.2 (sem) h, the fractional catabolic rate constant of the plasma pool was 0.025 ± 0 ...
Knot, E. A., de Jong, E., ten Cate, J. W., Gie, L. K., van Royen, E. A.   +4 more
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Biodistribution and Shedding of AAV Vectors

2011
Determining the AAV vector biodistribution and shedding is central for the safety assessment of proposed early-phase clinical trials. It is especially crucial in the case of AAV vectors since they are injected directly in situ with no possibility of an intermediate ex vivo step, such as in retroviral-mediated approaches.
Caroline, Le Guiner, Phillipe, Moullier, Valder R, Arruda   +2 more
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Liposome Biodistribution via Europium Complexes

2009
Vector biodistribution is a requirement prior pharmaceutical development. Radioactive tracers allow the most sensitive and quantitative assessment of biodistribution, and conventional fluorophores are widely used in academic laboratories. We propose here to use europium complexes as a label for nanoparticles or biotherapeutics taking liposomes as ...
Nathalie, Mignet, Daniel, Scherman
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Radioiodinated cyclosporin A: Preparation and biodistribution

The International Journal of Applied Radiation and Isotopes, 1980
Abstract A simple rapid procedure, using chloramine T, has been developed for labelling Cyclosporin A with 123 I or 125 I. The labelling yield exceeds 95% and the radioiodinated product is not decomposed after sterilization by autoclaving. Biodistribution studies in rats show that the radioiodinated Cyclosporin A is rapidly taken up by the liver ...
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