Results 91 to 100 of about 446,044 (333)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Bioengineering Support in the Assessment and Rehabilitation of Low Back Pain

Bioengineering
Low back pain (LBP) remains one of the most prevalent and disabling musculoskeletal conditions globally, with profound social, economic, and healthcare implications.
Giustino Varrassi, Matteo Luigi Giuseppe Leoni, Ameen Abdulhasan Al-Alwany, Piercarlo Sarzi Puttini, Giacomo Farì   +4 more
doaj   +1 more source

Perceived Intensity and Discrimination Ability for Lingual Electrotactile Stimulation Depends on Location and Orientation of Electrodes

Frontiers in Human Neuroscience, 2017
Malfunctioning sensory systems can severely impact quality of life and repair is not always possible. One solution, called sensory substitution, is to use another sensory system to bring lost information to the brain. This approach often involves the use
Leslie M. Stone-Roy, Joel Moritz Jr., Philip Turk, John D. Williams   +3 more
doaj   +1 more source

Numerical model for material parameter identification of cells [PDF]

, 2017
Bacteria have a complex external layer that render them with an increased stiffness and more resistant to external invasion. The works aims to model the squeezing of a bacteria between two walls, and deduce the composition of bacterial external layer ...
Roldán Blasco, Juan Pedro
core  

Finite element model set-up of colorectal tissue for analyzing surgical scenarios [PDF]

, 2017
Finite Element Analysis (FEA) has gained an extensive application in the medical field, such as soft tissues simulations. In particular, colorectal simulations can be used to understand the interaction with the surrounding tissues, or with instruments ...
Bici, Michele, Bini, Fabiano, Campana, Francesca, Guachi, Robinson, Marinozzi, Franco   +4 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

DNP Enhanced Frequency-Selective TEDOR Experiments in Bacteriorhodopsin [PDF]

, 2009
We describe a new approach to multiple [superscript 13]C–[superscript 15]N distance measurements in uniformly labeled solids, frequency-selective (FS) TEDOR. The method shares features with FS-REDOR and ZF- and BASE-TEDOR, which also provide quantitative
Bajaj, Bajaj, Bajaj, Baldus, Barnes, Bayro, Bennett, Delaglio, Goddard, Gullion, Helmus, Herzfeld, Herzfeld, Herzfeld, Herzfeld, Hing, Hornstein, Hu, Hu, Jaroniec, Jaroniec, Jaroniec, Jaroniec, Jaroniec, Jaroniec, Jehle, Judith Herzfeld, Lanyi, Lewandowski, Li, Li, Luecke, Lugtenburg, Mak-Jurkauskas, Marina Belenky, Markley, Mehta, Melody L. Mak-Jurkauskas, Michal, Petkova, Petkova, Rienstra, Robert G. Griffin, Rosay, Song, Stoeckenius, Ulrich, van der Wel, van der Wel, Veshtort, Vikram S. Bajaj, Vuister, Woskov   +52 more
core   +1 more source

Bioengineered Tubular Biliary Organoids

, 2023
Bilge Sen Elci, Mikhail Nikolaev, Saba Rezakhani, Matthias P. Lütolf   +3 more
openalex   +2 more sources

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Experimental Airway Allogenic Transplantation Model with Decellularized Cryopreserved Tracheas

Biomedicines
Background/Objectives: Tracheal replacement remains an unmet necessity in airway pathology treatment. We describe a decellularization and cryopreservation tracheal replacement protocol tested in vivo.
Néstor J. Martínez-Hernández, Lara Milián-Medina, Jorge Mas-Estellés, Amparo Roig-Bataller, David Hervás-Marín, Manuel Mata-Roig   +5 more
doaj   +1 more source