Results 91 to 100 of about 238,980 (322)
Molecular Oncology, EarlyView.VASP was found to be overexpressed in metastatic oral squamous cell carcinoma (OSCC) tissues. Notably, PTTG1‐ and VASP‐deficient OSCC cells demonstrated suppressed metastatic properties by disrupting the interaction between the cytoskeleton and focal adhesion (FAs) in the filopodia region.
Suyeon Park +6 more
wiley +1 more source
Multiple sclerosis clinical decision support system based on projection to reference datasets
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1863-1873, December 2022., 2022 Abstract Objective Multiple sclerosis (MS) is a multifactorial disease with increasingly complicated management. Our objective is to use on‐demand computational power to address the challenges of dynamically managing MS. Methods A phase 3 clinical trial data (NCT00906399) were used to contextualize the medication efficacy of peg‐interferon beta‐1a vs ...
Chadia Ed‐driouch +13 more
wiley +1 more source
The field of therapeutic medicine and drug discovery is undergoing a renaissance, marked by a renewed interest in natural products as a source of novel pharmaceuticals. In the age of advanced synthetic chemistry and biotechnology, the vast potential of natural compounds often remains untapped, yet history has repeatedly shown that nature harbors a ...
Srivastava, Arpit, Pandey, Ashutosh
openaire +2 more sources
Molecular Oncology, EarlyView.Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad +13 more
wiley +1 more source
Tooth bioengineering from single cell suspensions
MethodsX, 2019 Recent advances in bioengineering and biomaterials, along with knowledge deriving from the fields of developmental biology and stem cell research, have rendered feasible functional replacement of full organs.
Vassilis Stratoulias, Frederic Michon
doaj
Evaporative self-assembly of motile droplets [PDF]
arXiv, 2020 Self-assembly is the underlying building principle of biological systems and represents a promising approach for the future of manufacturing, but the yields are often limited by undesirable metastable states. Meanwhile, annealing methods have long been an important means to guide complex systems towards optimal states.
arxiv
Molecular Oncology, EarlyView.Patient‐derived xenografts (PDXs) can be improved by implantation of a humanized niche. We tested different biomaterials and approaches, and demonstrate that the combination of an injectable biomaterial for scaffold creation plus an intravenous route for acute myeloid leukemia (AML) xenotransplantation provide the most convenient and robust approach to
Daniel Busa +13 more
wiley +1 more source
Can all muscular load sharing patterns be regarded as optimal in some sense? [PDF]
Acta of Bioengineering and Biomechanics, Vol. 8, No. 2, 2006,
43-49, 2006 Muscles crossing a joint usually outnumber its degrees of freedom, which renders the motor system underdetermined. Typically, optimization laws are postulated to cope with this redundancy. A natural question then arises whether all muscular load sharing patterns can be regarded as results of optimization.
arxiv
Nonlinear optical contrast enhancement for optical coherence tomography [PDF]
, 2003 We present a new interferometric technique for measuring Coherent Anti-Stokes Raman Scattering (CARS) and Second Harmonic Generation (SHG) signals. Heterodyne detection is employed to increase the sensitivity in both CARS and SHG signal detection, which can also be extended to different coherent processes.
arxiv +1 more source
Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer
Molecular Oncology, EarlyView.This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu +7 more
wiley +1 more source