Results 181 to 190 of about 592,104 (329)

Insights into the Dynamics and Binding Mechanisms of the Alkhumra Virus NS2B/NS3 Protease: A Molecular Dynamics Study

Advanced Theory and Simulations, EarlyView.
The ΔRMSF$\Delta {\rm RMSF}$ analysis reveals significant flexibility differences between free NS3 and the NS2B/NS3 complex, with notable deviations in specific regions. Key residues driving NS2B binding are identified, and the protonation state of catalytic serine affects oxyanion hole formation.
Jurica Novak, Shivananda Kandagalla, Ramesh Sistla   +2 more
wiley   +1 more source

Autologous Peripheral Vγ9Vδ2 T Cell Synergizes with αβ T Cell Through Antigen Presentation and BTN3A1 Blockade in Immunotherapy of Cervical Cancer

Advanced Science, EarlyView.
This study provides proof‐of‐concept evidence showing that through direct killing, antigen presentation, and competitively binding to BTN3A1, Vγ9Vδ2 T cells amplified from cervical cancer (CC) patients can synergize with αβ T cells to exert anti‐CC function both in vitro and in vivo.
Min Wu, Jian Liu, Liting Liu, Yifan Yang, Hong Liu, Long Yu, Haihong Zeng, Shuo Yuan, Ruiyi Xu, Hangyu Liu, Han Jiang, Shen Qu, Liming Wang, Ying Chen, Jingyu Wang, Yuwei Zhang, Shan He, Ling Feng, Junyan Han, Wanjiang Zeng, Hui Wang, Yafei Huang   +21 more
wiley   +1 more source

BioArchLinux: community-driven fresh reproducible software repository for life sciences. [PDF]

Bioinformatics
Zhang G, Ristola P, Su H, Kumar B, Zhang B, Hu Y, Elliot MG, Drobot V, Zhu J, Staal J, Larralde M, Wang S, Yi Y, Yu H.   +13 more
europepmc   +1 more source

Bioinformatics - Challenges in 2001 [PDF]

, 2001
Chris Sander
openalex   +1 more source

Sustained Vaccine Exposure Elicits More Rapid, Consistent, and Broad Humoral Immune Responses to Multivalent Influenza Vaccines

Advanced Science, EarlyView.
This work presents an injectable polymer‐nanoparticle hydrogel depot platform for delivering multivalent influenza vaccines which induces stronger and more durable immune responses. The technology provides broader protection, including against heterologous and potential pandemic strains (H5N1, H7N9, H9N2), and enhances the effectiveness of commercial ...
Olivia M. Saouaf, Ben S. Ou, Ye Eun Song, Joshua J. Carter, Jerry Yan, Carolyn K. Jons, Christopher O. Barnes, Eric A. Appel   +7 more
wiley   +1 more source

Bioinformatic Analysis and Molecular Docking Identify Isorhamnetin Is a Candidate Compound in the Treatment of Pulmonary Artery Hypertension. [PDF]

Anatol J Cardiol
Shao C, Xia W, Liu Y.
europepmc   +1 more source

SeWeR: a customizable and integrated dynamic HTML interface to bioinformatics services [PDF]

, 2001
Malay Kumar Basu
openalex   +1 more source

Metabolic‐Immune Suppression Mediated by the SIRT1‐CX3CL1 Axis Induces Functional Enhancement of Regulatory T Cells in Colorectal Carcinoma

Advanced Science, EarlyView.
This study discovers that SIRT1, a hub gene involved in glucolipid metabolic conversion in colorectal carcinoma (CRC), stimulates CX3CL1 secretion in CRC cells by activating FOXO1. The CX3CL1‐CX3CR1 signaling promotes the differentiation of TCF7+ regulatory T cells (Tregs) into an enhanced immunosuppressive TNFRSF9+ Treg phenotype.
Ruiyang Zi, Xiang Zhao, Limei Liu, Yijie Wang, Rui Zhang, Zhiheng Bian, Haoran Jiang, Taorui Liu, Yixin Sun, Han Peng, Xuesong Wang, Fanghao Lu, Chao Zhang, Fan Zhang, Qing Qin, Houjie Liang, Jianjun Li, Zhihao Wei, Yan Dong   +18 more
wiley   +1 more source

High-Performance Genome Annotation for a Safer and Faster-Developing Phage Therapy. [PDF]

Viruses
Culot A, Abriat G, Furlong KP.
europepmc   +1 more source

Bioinformatics: Use in Bacterial Vaccine Discovery [PDF]

, 2001
Robert J. Zagursky, David H. Russell
openalex   +1 more source