Results 51 to 60 of about 1,060,544 (307)
Diffusion Models in Bioinformatics: A New Wave of Deep Learning Revolution in Action [PDF]
arXiv, 2023 Denoising diffusion models have emerged as one of the most powerful generative models in recent years. They have achieved remarkable success in many fields, such as computer vision, natural language processing (NLP), and bioinformatics. Although there are a few excellent reviews on diffusion models and their applications in computer vision and NLP ...
arxiv
Overview of Random Forest Methodology and Practical Guidance with Emphasis on Computational Biology and Bioinformatics [PDF]
, 2012 The Random Forest (RF) algorithm by Leo Breiman has become a standard data analysis tool in bioinformatics. It has shown excellent performance in settings where the number of variables is much larger than the number of observations, can cope with ...
Boulesteix, Anne-Laure +3 more
core +1 more source
FEBS Letters, EarlyView.Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung +6 more
wiley +1 more source
Keemei: cloud-based validation of tabular bioinformatics file formats in Google Sheets. [PDF]
, 2016 BackgroundBioinformatics software often requires human-generated tabular text files as input and has specific requirements for how those data are formatted.
Ackermann, Gail +6 more
core +2 more sources
Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases
FEBS Letters, EarlyView.The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher +6 more
wiley +1 more source
Genomics, Proteomics & Bioinformatics, 2015 A starting point of curating bioinformatic resources for the public is marked by the establishment of the US National Center for Biotechnology Information (NCBI) in 1988 [1]. One of its many purposes is certainly to echo the initiative of the Human Genome Project (HGP) –– when two landmark reports were published at the same time: “Mapping and ...
openaire +4 more sources
Bioinformatics and the eye [PDF]
Journal of Ocular Biology, Diseases, and Informatics, 2009 Bioinformatics evolved to become a recognized scientific discipline during the last decade of the twentieth century, due in part to the Human Genome Project and the introduction of microarray expression profiling, both of which involved critical computational activities.
openaire +3 more sources
Matchmaking in Bioinformatics [PDF]
F1000Research, 2018 Ever return from a meeting feeling elated by all those exciting talks, yet unsure how all those presented glamorous and/or exciting tools can be useful in your research? Or do you have a great piece of software you want to share, yet only a handful of people visited your poster?
Ewy Mathé, Ben Busby, Helen Piontkivska
openaire +3 more sources
FEBS Letters, EarlyView.We present the first solution structure of the Ca2+‐depleted LETM1 F‐EF‐hand through a D676A/N678A Ca2+ binding‐deficient mutant, revealing a closed hydrophobic cleft caused by a unique F1‐helix pivot. The apo LETM1 F‐EF‐hand exhibits regiospecific hot and cold unfolding, sensitivity to physiological pH changes and potential for promiscuous heterotypic
Qi‐Tong Lin +2 more
wiley +1 more source
FEBS Letters, EarlyView.This study explores the distinct molecular mechanisms underlying Lynch syndrome‐associated and sporadic colorectal cancer (CRC). By highlighting the therapeutic potential of targeting the PI3K‐Akt pathway in Lynch syndrome‐associated CRC and the Wnt pathway in sporadic CRC, the findings open avenues for personalised treatment strategies, aiming to ...
May J. Krause +2 more
wiley +1 more source