Results 61 to 70 of about 1,060,544 (307)

Streamlined and on-demand preparation of mRNA products on a universal integrated platform

Microsystems & Nanoengineering, 2023
Vaccines are used to protect human beings from various diseases. mRNA vaccines simplify the development process and reduce the production cost of conventional vaccines, making it possible to respond rapidly to acute and severe diseases, such as ...
Hongjuan Wei, Zhen Rong, Liyan Liu, Ye Sang, Jing Yang, Shengqi Wang   +5 more
doaj   +1 more source

Bioinformatics advances in saliva diagnostics [PDF]

, 2012
There is a need recognized by the National Institute of Dental & Craniofacial Research and the National Cancer Institute to advance basic, translational and clinical saliva research. The goal of the Salivaomics Knowledge Base (SKB) is to create
B Smith, Barry Smith, C Phillips, CM Huang, DA Natale, David TW Wong, DP Ng, E Birney, I Garcia, I Takeda, J Ai, Ji-Ye Ai, JM Guberman, K Degtyarenko, M Ashburner, P Grenon, RR Brinkman, S Hu   +17 more
core   +2 more sources

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source

The Genome Solver Project: Faculty Training and Student Performance Gains in Bioinformatics

Journal of Microbiology & Biology Education, 2019
Bioinformatics brings together biology, mathematics, statistics, and computer science to analyze biological sequence information. Anyone with a computer, access to the Internet, and basic training in this field can contribute to genomics research.
Vinayak Mathur, Gaurav S. Arora, Mindy McWilliams, Janet Russell, Anne G. Rosenwald   +4 more
doaj   +1 more source

Bioconductor: open software development for computational biology and bioinformatics. [PDF]

, 2004
The Bioconductor project is an initiative for the collaborative creation of extensible software for computational biology and bioinformatics. The goals of the project include: fostering collaborative development and widespread use of innovative software,
Bates, Douglas, Bolstad, Ben, Carey, Vincent, Dettling, Marcel, Dudoit, Sandrine, Ellis, Byron, Gautier, Laurent, Ge, Yongchao, Gentleman, Robert, Gentry, Jeff, Hornik, Kurt, Hothorn, Torsten, Huber, Wolfgang, Iacus, Stefano, Irizarry, Rafael, Leisch, Friedrich, Li, Cheng, Maechler, Martin, Rossini, Anthony, Sawitzki, Gunther, Smith, Colin, Smyth, Gordon, Tierney, Luke, Yang, Jean, Zhang, Jianhua   +24 more
core   +6 more sources

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

A streamlined platform for analyzing tera-scale DDA and DIA mass spectrometry data enables highly sensitive immunopeptidomics

Nature Communications, 2022
Immunopeptidomics benefits from highly sensitive mass spectrometry (MS). Here, the authors present a computational platform for integrating data-dependent and -independent acquisition MS approaches, and demonstrate its utility for deeper immunopeptidome ...
Lei Xin, Rui Qiao, Xin Chen, Hieu Tran, Shengying Pan, Sahar Rabinoviz, Haibo Bian, Xianliang He, Brenton Morse, Baozhen Shan, Ming Li   +10 more
doaj   +1 more source

Predictive Modelling in Clinical Bioinformatics: Key Concepts for Startups

BioTech, 2022
Clinical bioinformatics is a newly emerging field that applies bioinformatics techniques for facilitating the identification of diseases, discovery of biomarkers, and therapy decision.
Ricardo J. Pais
doaj   +1 more source

Short Courses: Flexible Learning Opportunities in Informatics [PDF]

, 2018
In today’s fast-paced, data-driven world, researchers need to have a good foundation in informatics to store, organize, process, and analyze growing amounts of data. However, not all degree programs offer such training.
Arendt, Julie, Gau, Karen H, Moeller, F. Gerard, Olex, Amy, Wolen, Aaron R.   +4 more
core   +1 more source