Results 61 to 70 of about 1,477,984 (353)
Single-cell RNA sequencing technologies and bioinformatics pipelines
Experimental and Molecular Medicine, 2018 Rapid progress in the development of next-generation sequencing (NGS) technologies in recent years has provided many valuable insights into complex biological systems, ranging from cancer genomics to diverse microbial communities.
Byungjin Hwang, J. Lee, Duhee Bang
semanticscholar +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
PLoS Computational Biology, 2019 Bioinformatics has become an indispensable part of life science over the past 2 decades. However, bioinformatics education is not well integrated at the undergraduate level, especially in liberal arts colleges and regional universities in the United ...
Yingqian Ada Zhan +5 more
doaj +1 more source
Streamlined and on-demand preparation of mRNA products on a universal integrated platform
Microsystems & Nanoengineering, 2023 Vaccines are used to protect human beings from various diseases. mRNA vaccines simplify the development process and reduce the production cost of conventional vaccines, making it possible to respond rapidly to acute and severe diseases, such as ...
Hongjuan Wei +5 more
doaj +1 more source
Simulated single molecule microscopy with SMeagol
, 2016 SMeagol is a software tool to simulate highly realistic microscopy data based on spatial systems biology models, in order to facilitate development, validation, and optimization of advanced analysis methods for live cell single molecule microscopy data ...
Boucharin, Alexis +4 more
core +2 more sources
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Nature Communications, 2022 Immunopeptidomics benefits from highly sensitive mass spectrometry (MS). Here, the authors present a computational platform for integrating data-dependent and -independent acquisition MS approaches, and demonstrate its utility for deeper immunopeptidome ...
Lei Xin +10 more
doaj +1 more source
GPU cards as a low cost solution for efficient and fast classification of high dimensional gene expression datasets [PDF]
, 2010 The days when bioinformatics tools will be so reliable to become a standard aid in routine clinical diagnostics are getting very close. However, it is important to remember that the more complex and advanced bioinformatics tools become, the more ...
Benso, Alfredo +4 more
core
TFBSTools: an R/bioconductor package for transcription factor binding site analysis. [PDF]
, 2016 Summary: The ability to efficiently investigate transcription factor binding sites (TFBSs) genome-wide is central to computational studies of gene regulation.
Lenhard, B, Tan, G
core +2 more sources
The bioinformatics toolbox for circRNA discovery and analysis
Briefings Bioinform., 2020 Circular RNAs (circRNAs) are a unique class of RNA molecule identified more than 40 years ago which are produced by a covalent linkage via back-splicing of linear RNA.
Liang Chen +6 more
semanticscholar +1 more source