Results 101 to 110 of about 541,804 (167)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Effect of salidroside on the immune function of BCG-infected macrophages

Shanghai Jiaotong Daxue xuebao. Yixue ban
Objective·To Investigate the effects of salidroside (SAL) on the immune response of macrophages infected with BCG.Methods·RAW264.7 mouse macrophages were infected with BCG, and the experiments were divided into blank control (BCG), salidroside (SAL+BCG),
NI Shuyi, JIANG Zhao, WANG Zhongtao, HE Shumei   +3 more
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Bioinformatics for Genome Analysis [PDF]

, 2005
Nesbo, Boucher and Doolittle (2001) used phylogenetic trees of four taxa to assess whether euryarchaeal genes share a common history. They have suggested that of the 521 genes examined, each of the three possible tree topologies relating the four taxa was supported essentially equal numbers of times.
openaire   +2 more sources

Development of Bioinformatics Infrastructure for Genomics Research in H3Africa [PDF]

, 2017
Background: Although pockets of bioinformatics excellence have developed in Africa, generally, large-scale genomic data analysis has been limited by the availability of expertise and infrastructure.
Adebiyi, Ezekiel, Adebiyi, Marion O., Adeyemi, S., Ahmed, A., Ahmed, R., Akanle, B., Alibi, M., Armstrong, D. L., Aron, S., Ashanoz, E., Baichoo, S., Benkahla, A., Bishop, OzlemTastan, Brown, D. K., Chimusa, E., Fadlelmolak, F. M., Falola, O., Fatumo, S., Ghedira, Kais, Ghouila, Amel, Hazelhurst, S., Isewon, Itunuoluwa, Jung, S., Kassim, S. K., Kayondo, J. K., Mbiyavanga, M., Meintjes, A., Mohammed, S., Mosaku, Abayomi, Moussa, A., Muhammd, M., Mulder, Nicola J., Mungloo-Dilmohamud, Z., Nashiru, Oyekanmi, Odia, Trust, Okafor, A., Oladipo, O., Osamor, V. C., Oyelade, O. J., Panji, Sumir, Radouani, F., Sadki, K., Salifu, S. P., Souiai, O., Soyemi, J.   +44 more
core  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Characterization of the human patatin-like phospholipase familys⃞

Journal of Lipid Research, 2006
Several publications have described biological roles for human patatin-like phospholipases (PNPLAs) in the regulation of adipocyte differentiation. Here, we report on the characterization and expression profiling of 10 human PNPLAs.
Paul A. Wilson, Scott D. Gardner, Natalie M. Lambie, Stephane A. Commans, Daniel J. Crowther   +4 more
doaj   +1 more source

Evaluation of IoT-Based Computational Intelligence Tools for DNA Sequence Analysis in Bioinformatics

, 2019
In contemporary age, Computational Intelligence (CI) performs an essential role in the interpretation of big biological data considering that it could provide all of the molecular biology and DNA sequencing computations.
Alansari, Zainab, Anuar, Nor Badrul, Belgaum, Mohammad Riyaz, Kamsin, Amirrudin, Soomro, Safeeullah   +4 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

A qualitative approach to the identification, visualisation and interpretation of repetitive motion patterns in groups of moving point objects [PDF]

, 2015
Discovering repetitive patterns is important in a wide range of research areas, such as bioinformatics and human movement analysis. This study puts forward a new methodology to identify, visualise and interpret repetitive motion patterns in groups of ...
Chavoshi, Seyed Hossein, De Baets, Bernard, De Tré, Guy, Neutens, Tijs, Qiang, Yi, Van de Weghe, Nico   +5 more
core   +1 more source