Results 161 to 170 of about 16,621,712 (406)

Avocado seeds (Persea americana cv. Criollo sp.): Lipophilic compounds profile and biological activities

, 2021
Cid-Pérez Teresa Soledad, Hernández-Carranza Paola, Carlos Enrique Ochoa‐Velasco, I.I. Ruiz-López, Nevárez-Moorillón GuadalupeVirginia, Raúl Ávila-Sosa   +5 more
openalex   +1 more source

Should Soil Testing Services Measure Soil Biological Activity?

, 2016
Soil biological activity is a key indicator for productivity and environmental quality. The flush of CO2 possesses many qualities of a robust soil test. Field calibration is underway to relate the flush of CO2 to nitrogen availability.
A. Franzluebbers
semanticscholar   +1 more source

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

FEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

Evaluation of In Vivo Biological Activity Profiles of Isoindole-1,3-dione Derivatives: Cytotoxicity, Toxicology, and Histopathology Studies [PDF]

, 2023
Aytekin Köse, Meltem Kaya, Canberk Tomruk, Yiğit Uyanıkgil, Nurhan Kishalı, Yunus Kara, Gülşah Şanlı‐Mohamed   +6 more
openalex   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Synthesis, computational studies and In Silico approaches of novel organophosphorus derivatives as anti-Alzheimer Agents

Scientific African
A novel established of compounds as 1,2-oxaphosphol-3-ene 3 and tetraethyl 4-nitroalk-1-ene-2,3-diyldiphosphonate 4a-e were synthesized through the coupling reaction of phosphonoallyl bromide E-2 with triethyl ammonium formate (TEAF) and nitroalkane ...
Maha Ameur, Rania Omrani, Sonia Taktouk, Anis Raddaoui, Ahmed Ridha El Ouederni, Rafik Gatri   +5 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Eco-friendly Synthesis, antibacterial evaluation and in-silico profiling of Thioamide derivatives as dual-action potential dual-action agents

Results in Chemistry
An efficient, solvent-free synthesis of novel phosphono fluoro thioamidate derivatives 1–5 was achieved by reacting isothiocyanate derivatives with bis(2,2,2-trifluoroethyl) phosphonate at room temperature.
Rania Omrani, Imen Kharmachi, Sonia Taktouk, Mohamed Amine Ben Abdallah, Anis Raddaoui, Azaiez Ben Akacha   +5 more
doaj   +1 more source

Recent advances on synthesis and biological activities of aurones

, 2020
Guoqing Sui, Tian Li, Bingyu Zhang, Ruizhi Wang, Hong‐Dong Hao, Wenming Zhou   +5 more
openalex   +1 more source