Results 81 to 90 of about 16,187,582 (338)

Computer-aided Prediction of Biological Activity Spectra for Chemical Compounds: Opportunities and Limitations

, 2018
An essential characteristic of chemical compounds is their biological activity since its presence can become the basis for the use of the substance for therapeutic purposes, or, on the contrary, limit the possibilities of its practical application due to
D. Filimonov, D. Druzhilovskiy, A. Lagunin, T. Gloriozova, A. Rudik, A. Dmitriev, P. Pogodin, V. Poroikov   +7 more
semanticscholar   +1 more source

Role of sphingolipids in the biogenesis and biological activity of extracellular vesicles

Journal of Lipid Research, 2018
Extracellular vesicles (EVs) are membrane vesicles released by both eukaryotic and prokaryotic cells; they not only serve physiological functions, such as disposal of cellular components, but also play pathophysiologic roles in inflammatory and ...
C. Verderio, M. Gabrielli, P. Giussani
semanticscholar   +1 more source

Synthesis of N-p-Fluorothiosemicarbazone and of Bis(N-p-Fluorophenylthiourea): Crystal Structure and Conformational Analysis of N,N′-Bis(4-Fluorophenyl)Hydrazine-1,2-Bis(Carbothioamide)

Molbank
The reaction of the phosphonated hydrazone (2-hydrazineylidenepropyl) diphenylphosphine oxide 1 with p-fluorophenyl-isothiocyanate yields as a major product the thiosemicarbazone Ph2P(=O)CH2{C=N-NH(C=S)-N(H)C6H4F}CH3 (2-(1-(diphenylphosphoryl)propan-2 ...
Sirine Salhi, Dorra Kanzari-Mnallah, Isabelle Jourdain, Michael Knorr, Carsten Strohmann, Jan-Lukas Kirchhoff, Hédi Mrabet, Azaiez Ben Akacha   +7 more
doaj   +1 more source

The Evaluation Of Molecular Similarity And Molecular Diversity Methods Using Biological Activity Data [PDF]

, 2004
This paper reviews the techniques available for quantifying the effectiveness of methods for molecule similarity and molecular diversity, focusing in particular on similarity searching and on compound selection procedures.
Willett, P.
core   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Physicochemical Properties, Biological Activity, Health Benefits, and General Limitations of Aged Black Garlic: A Review

Molecules, 2017
Garlic (Allium sativum) has been used as a medicinal food since ancient times. However, some people are reluctant to ingest raw garlic due to its unpleasant odor and taste.
J. Ryu, D. Kang
semanticscholar   +1 more source

Biological Activity of Enzymatically Synthesized Polyphenol Glycoside on Microbial Growth [PDF]

, 2002
Biological Activity of Enzymatically Synthesized Polyphenol Glycoside on Microbial Growth. We have studied an indigenous bacterial strain produced a glycosyl transfer enzyme (CGTase) yielding polyphenol glycosides from a substrate of starch and ...
Soeka, Y. S. (Yati), Sulistyo, J. (Joko), Widiasih, L. E. (Lutfi)   +2 more
core  

A preliminary report on the contact-independent antagonism of Pseudogymnoascus destructans by Rhodococcus rhodochrous strain DAP96253. [PDF]

, 2014
BackgroundThe recently-identified causative agent of White-Nose Syndrome (WNS), Pseudogymnoascus destructans, has been responsible for the mortality of an estimated 5.5 million North American bats since its emergence in 2006.
Barlament, Courtney K, Cornelison, Christopher T, Crow, Sidney A, Gabriel, Kyle T, Keel, M Kevin, Pierce, George E, Tucker, Trudy A   +6 more
core   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Glycosylation Is a Major Regulator of Phenylpropanoid Availability and Biological Activity in Plants

Frontiers in Plant Science, 2016
The phenylpropanoid pathway in plants is responsible for the biosynthesis of a huge amount of secondary metabolites derived from phenylalanine and tyrosine. Both flavonoids and lignins are synthesized at the end of this very diverse metabolic pathway, as
J. Le Roy, B. Huss, A. Créach, S. Hawkins, G. Neutelings   +4 more
semanticscholar   +1 more source