Results 121 to 130 of about 1,535,781 (307)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
PHYSIOLOGICAL AGE OF IXODID TICKS AND THE CONCEPT OF BIOLOGICAL AGE
, 2020 The definition concept of the «physiological age» of animals has been revised based on the studies of ixodid ticks. The physiological age of animals is considered to be a general biological notion and is equal to the notion «biological age» of human ...
Razumova I.V.
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
SportsThis study examines the maturity status and relative age effect in elite youth taekwondo Croatian National Team athletes. Measurements of biological age, maturity offset, and body composition were taken from a sample of 17 junior athletes. Differences in
Ana Kezic, Matej Babic, Drazen Cular
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Biological and sociological interpretations of age-adjustment in studies of higher order birth rates [PDF]
Several studies of the effect of education on second or third birth rates (e.g. Hoem et al. (2001)) have used the concept of relative age at previous birth (B.Hoem (1996)). B.Hoem's idea was to focus on the social meaning of age at previous birth.
Mette Gerster, Niels Keiding
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Chronological age determination for adopted children [PDF]
, 2004 This paper has been prepared as a submission to the Queensland Intercountry Adoption Unit regarding policy development for requests to amend a child’s date of birth.
Pedersen, Cec
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