Results 171 to 180 of about 3,274,267 (305)

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

A urinary microRNA aging clock accurately predicts biological age. [PDF]

NPJ Aging
Havelka M, Satomura A, Yamaguchi H, Cortal A, Ando Y, Mikami M, Mizunuma M, Ichikawa Y.   +7 more
europepmc   +1 more source

Checkpoint blockade and the stem‐like T cell trade‐off

Molecular Oncology, EarlyView.
Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley   +1 more source

Epigenetic clocks: advancing biological age measures towards meaningful clinical use. [PDF]

EBioMedicine
eBioMedicine.
europepmc   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Biological age acceleration associates with Alzheimer's disease plasma biomarker levels. [PDF]

Alzheimers Dement
Eissman JM, Ma Y, Qiao M, Reyes-Dumeyer D, Piriz A, Lee AJ, Lantigua RA, Medrano M, Mejia DR, Honig LS, Grodstein F, Bennett DA, De Jager PL, Dalgard CL, Mayeux R, Vardarajan BN.   +15 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Prediction of biological age using machine learning. [PDF]

PLoS One
Zhang K, Chen PC, Huang Y, Tzou SJ, Wu ST, Chu TW, Wang CC, Jang JR.   +7 more
europepmc   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Association of pregnancy history and unhealthy lifestyle with biological age acceleration: a large cross-sectional study. [PDF]

Front Public Health
Yao Y, Yin S, Si K, Li D, Yuan L, Yang Y, Li Z, Wu G.   +7 more
europepmc   +1 more source