Results 181 to 190 of about 1,535,781 (307)

Biological Age Should Anchor Age-Related Disease Research. [PDF]

Aging Dis
Shakeel H, Jin D, Jin K.
europepmc   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Retinal biological age correlates with bone mineral density and fracture risk score and predicts incident osteoporosis. [PDF]

PLOS Digit Health
Peng Q, Xue CC, Chua K, Li H, Nusinovici S, Soh ZD, Gupta P, Leem AY, Yu MCY, Sabanayagam C, Rim TH, Zhu Z, Lamoureux E, Cheng CY.   +13 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

The Influence of Biological Age and Sex on Gross Motor Skill Development in Young Athletes: A Pilot Study. [PDF]

Sports (Basel)
Chapelski MS, Tait T, Woods S, Benson S, Erlandson MC, Humbert ML, Baxter-Jones ADG.   +6 more
europepmc   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Longitudinal associations of sarcopenia and biological age acceleration with rate of cognitive decline. [PDF]

BMC Public Health
Hou Y, Long R, Sun Q, Zhang Y, Wang K.
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

OMICmAge quantifies biological age by integrating multi-omics with electronic medical records. [PDF]

Nat Aging
Chen Q, Dwaraka VB, Carreras-Gallo N, Armstrong JF, Sehgal R, Argentieri MA, Richmond A, Aparicio A, Mendez K, Chen Y, Begum S, Kachroo P, Prince N, Guo T, Went H, Mendez T, Lin A, Turner L, Moqri M, Chu SH, Kelly RS, Weiss ST, Rattray NJW, Gladyshev VN, Karlson E, Wheelock CE, Mathé EA, Dahlin A, McGeachie MJ, Marioni RE, Higgins-Chen AT, Smith R, Lasky-Su J.   +32 more
europepmc   +1 more source