Results 211 to 220 of about 3,274,267 (305)

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Joint Association of Diet Index for Gut Microbiota and MVPA With Central Obesity: The Mediating Role of Biological Age. [PDF]

Food Sci Nutr
Zhou Q, Tang C, Pan X, Lu Z, Chen R, Gong X.   +5 more
europepmc   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Association of the dietary inflammatory index with multi-organ biological age acceleration. [PDF]

J Health Popul Nutr
Long L, Cheng J, Zhang Y, Yu P, Li Q, Liu X, Li J.   +6 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Biological age in critical care: current evidence, future prospects, and clinical implications. [PDF]

Front Med (Lausanne)
Jiang LB, Han W.
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Biologically Younger Individuals, as Identified by MARK-AGE Biological Age Scores, Display a Distinct Favourable Blood Chemistry Profile Regardless of Age. [PDF]

Aging Cell
Moreno-Villanueva M, Junk M, Mosieniak G, Sikora E, Capri M, Garagnani P, Pirazzini C, Breusing N, Bernhardt J, Schön C, Blasco M, Zondag G, Debacq-Chainiaux F, Grubeck-Loebenstein B, Weinberger B, Fiegl S, Mocchegiani E, Malavolta M, Giacconi R, Piacenza F, Collino S, Gonos ES, Gradinaru D, Dollé MET, Jansen E, Salmon M, Kristensen P, Griffiths H, Libert C, Vanhooren V, Simm A, Talbot D, Caiafa P, Bacalini MG, Zampieri M, Friguet B, Petropoulos I, Slagboom PE, Westendorp R, Hervonnen A, Hurme M, Aspinall R, Govind S, Weber D, Stuetz W, Hoeijmakers JHJ, Gavriushina I, Sampson OR, Castellani G, Berthold MR, Grune T, Franceschi C, Bürkle A.   +52 more
europepmc   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source