Results 121 to 130 of about 3,406,662 (333)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

How ageing is shaped by trade-offs [PDF]

The evolution of different life history strategies and thus different ageing patterns essentially depends on the nature of the underlying trade-offs between survival and reproduction.
Annette Baudisch
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Repeated stressors in adulthood increase the rate of biological ageing

Frontiers in Zoology, 2015
Individuals of the same age can differ substantially in the degree to which they have accumulated tissue damage, akin to bodily wear and tear, from past experiences.
M. Hau, M. Haussmann, T. Greives, Christa Matlack, D. Costantini, Michael Quetting, J. Adelman, A. C. Miranda, J. Partecke   +8 more
semanticscholar   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Demystifying ageing.

, 2012
Many developed countries today face the problem of having an ageing population, yet there is a lack of a consolidated understanding of how ageing occurs and how it should be addressed. Stereotypical perceptions of ageing run deep within the minds of most
Liu, Benjamin Zibin.
core  

MARK-AGE biomarkers of ageing

, 2015
Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine,
Grubeck-Loebenstein, B, Burkle, A, Kristensen, P, Toussaint, O., Sikora, E, Jan H. J. Hoeijmakers (10845649), Blasco, M, Aspinall, R, Ewa Sikora (614482), Hervonen, A., Aspinall, R., Bernhard, J., Bernhard, Jürgen, Hoeijmakers, J.H.J., Caiafa, P., Talbot, D, Toussaint, Olivier, Hoeijmakers, Jan H.J., Hervonen, Antti, Breusing, Nicolle, Breusing, N, Griffiths, Helen R, Hoeijmakers, Jan H J, Gradinaru, D., Griffiths, H.R., Collino, S, Moreno Villanueva, María, Moreno-Villanueva, M, Mocchegiani, E, Kristensen, Peter, Sikora, E., Martijn Dollé (4991555), Gonos, Efstathios S., Blasco, María, Hoeijmakers, Jan HJ, Libert, C., Claudio Franceschi (68521), María Moreno-Villanueva (16669899), Zondag, Gerben, Zondag, G, Olivier Toussaint (5593), Bürkle, Alexander, Hoeijmakers, Jan, Eugenio Mocchegiani (16669908), Slagboom, P.E., Daniela Gradinaru (16669911), Griffiths, Helen R., Miriam Capri (179583), Hoeijmakers, Jan H. J., Bernhard, J, Grune, T, Libert, Claude, Mocchegiani, E., Slagboom, P Eline, Helen R. Griffiths (155473), Grubeck-Loebenstein, B., Friguet, Bertrand, Alexander Bürkle (27570), Andreas Simm (591325), Bertrand Friguet (687284), Capri, Miriam, Michel Salmon (249492), Sikora, Ewa, Franceschi, C, María Blasco (16669905), Salmon, Michel, Kristensen, P., Friguet, B, Grubeck-Loebenstein, Beatrix, Capri, M., Libert, C, Dollé, Martijn, Efstathios S. Gonos (1296909), Paola Caiafa (132394), Capri, M, Slagboom, P. Eline, Caiafa, P, Simm, A., Claude Libert (493718), Zondag, G., Caiafa, Paola, Grune, T., Hervonen, A, Slagboom, PE (Eline), Griffiths, HR, Collino, Sebastiano, Grune, Tilman, Breusing, N., Dolle, M., Jürgen Bernhard (16669902), Dolle, M, Gonos, ES, Mocchegiani, Eugenio, Antti Hervonen (239717), Franceschi, C., Hurme, M, Sebastiano Collino (385873), Duncan Talbot (477839), Moreno-Villanueva, M., Beatrix Grubeck-Loebenstein (12622), Talbot, Duncan, Gonos, Efstathios S, Burkle, A., Hurme, Mikko, Toussaint, O, Grubeck Loebenstein, Beatrix, Moreno-Villanueva, María, Gradinaru, D, Peter Kristensen (467952), Friguet, B., Aspinall, Richard, Talbot, D., Blasco, M., Richard Aspinall (348825), P. Eline Slagboom (9318264), Salmon, M., Simm, Andreas, Gradinaru, Daniela, Franceschi, Claudio, Hurme, M., Collino, S., Mikko Hurme (240666), Simm, A, Gerben Zondag (2270743), Tilman Grune (1296930), Nicolle Breusing (1296924), Gonos, E.S., Salmon, M   +127 more
core   +1 more source

Identification of Molecular Markers of Delayed Graft Function Based on the Regulation of Biological Ageing

PLoS ONE, 2016
Introduction Delayed graft function is a prevalent clinical problem in renal transplantation for which there is no objective system to predict occurrence in advance.
D. McGuinness, J. Leierer, Olivier Shapter, Suhaib K Mohammed, M. Gingell-Littlejohn, D. Kingsmore, A. Little, Julia Kerschbaum, S. Schneeberger, M. Maglione, S. Nadalin, Sylvia Wagner, A. Königsrainer, E. Aitken, H. Whalen, M. Clancy, A. McConnachie, C. Koppelstaetter, K. Stevenson, P. Shiels   +19 more
semanticscholar   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source