Results 131 to 140 of about 3,406,662 (333)

Mechanics of Ageing—From Building to Biological Materials

, 2017
In this work, we present a general model for the analysis of concrete and biological tissues as multiphase porous materials, with particular regard to their ageing.
Santagiuliana, R., Sciumè, G., Sciumè, Giuseppe, Schrefler, B., R. Santagiuliana, Pesavento, F., Schrefler, B. A., F. Pesavento, B. A. Schrefler, G. Sciumè   +9 more
core   +1 more source

Adverse events in both childhood and adulthood are associated with molecular, clinical and functional markers of ageing

BMC Medicine
Background Adverse events across the lifespan have been linked to poorer health outcomes, but the biological mechanisms remain unclear. The aim of this study was to quantify the independent and joint associations of adversity experienced in childhood and/
Monica Aas, Thole H Hoppen, Nexhmedin Morina, Shiyu Zhang, Bin Li, Vid Mlakar, Julian Mutz   +6 more
doaj   +1 more source

Correction of physical education program for technical higher educational establishment girl-students on the base of their health indicators

Physical Education of Students, 2016
Purpose: to illustrate opportunities of physical education in health strengthening of technical HEE girl-students through correction of their biological age components. Material: 127 girl-students participated in the research.
A.N. Kolumbet, L.Yu. Dudorova
doaj   +1 more source

Biological ageing and frailty markers in breast cancer patients

Aging, 2015
Older cancer patients are a highly heterogeneous population in terms of global health and physiological reserves, and it is often difficult to determine the best treatment. Moreover, clinical tools currently used to assess global health require dedicated
B. Brouwers, B. Dalmasso, S. Hatse, A. Laenen, C. Kenis, E. Swerts, P. Neven, A. Smeets, P. Schöffski, H. Wildiers   +9 more
semanticscholar   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Local and global patterns support medical imaging as a biomarker of ageing

Communications Medicine
Background Understanding human ageing across multiple organs is essential for characterising individual health trajectories and identifying abnormal ageing processes.
Tamara T. Mueller, Sophie Starck, Rozafë Llalloshi, Georgios Kaissis, Alexander Ziller, Robert Graf, Christopher Schlett, Steffen Ringhof, Fabian Bamberg, Mark Wielpütz, Henry Völzke, Michael Leitzmann, Thoralf Niendorf, Thomas Keil, Lilian Krist, Tobias Pischon, André Karch, Klaus Berger, Jan Kirschke, Daniel Rueckert, Rickmer Braren   +20 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Slowed Gompertzian ageing in long-lived C. elegans results from expansion of decrepitude, not decelerated ageing

Nature Communications
In populations of many animal species, including humans, mortality rates increase exponentially with advancing age. The scale and rate of increase can be set by two parameters, α and β, respectively, of the Gompertz equation.
Bruce Zhang, David Gems
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

New insights into healthy ageing, inflammageing and frailty using metabolomics

Frontiers in Aging
Human ageing is a normal process and does not necessarily result in the development of frailty. A mix of genetic, environmental, dietary, and lifestyle factors can have an impact on ageing, and whether an individual develops frailty.
Genna Abdullah, Asangaedem Akpan, Asangaedem Akpan, Asangaedem Akpan, Asangaedem Akpan, Marie M. Phelan, Marie M. Phelan, Helen L. Wright   +7 more
doaj   +1 more source